Core Viewpoint - Jazz Pharmaceuticals is expected to report first-quarter 2025 earnings on May 6, with sales estimated at $978.6 million and earnings at $4.61 per share, reflecting a positive trend in earnings estimates for 2025 [1][3]. Financial Performance - Jazz Pharmaceuticals has exceeded earnings expectations in three of the last four quarters, with a trailing four-quarter average earnings surprise of 3.20% and a notable earnings surprise of 13.99% in the last quarter [3]. - The company currently has an Earnings ESP of -2.75% and a Zacks Rank of 3 (Hold) [5]. Revenue Segments - The company reports financial figures under two segments: Neuroscience and Oncology. The consensus estimate for neuroscience product sales is $649 million, while the estimate for oncology sales is $269 million [7][10]. - Sales of the sleep disorder drug Xywav are projected at $372 million, with expectations of continued growth due to its uptake in narcolepsy and idiopathic hypersomnia [8]. - Epidiolex sales are expected to rise to $234 million, driven by geographic expansion, while sales of the legacy drug Xyrem are anticipated to decline [9]. Oncology Performance - Sales of the chemotherapy drug Rylaze are expected to be impacted by recent updates to treatment protocols, with estimates pegged at $103 million [11]. - Other oncology drugs, including Zepzelca, Vyxeos, and Defitelio, are expected to grow at a mid-single-digit percentage during the quarter [11]. Stock Performance and Valuation - Jazz Pharmaceuticals' shares have declined about 6% year-to-date, compared to a 4% decline in the industry, and are currently trading below their 50-day and 200-day moving averages [13]. - The stock is trading at a price-to-sales (P/S) ratio of 1.76, lower than the industry average of 1.97 and below its five-year mean of 2.70, indicating a valuation discount [16]. Investment Thesis - The company has a diversified portfolio in neuroscience and oncology, although pipeline setbacks, such as the discontinuation of suvecaltamide development, pose concerns [18]. - Strategic acquisitions have bolstered the pipeline, with five oncology products marketed and an FDA decision on a sixth product expected by August 18 [19][20]. - Despite challenges, the rising EPS estimates for 2025 and a robust cash reserve of $3.0 billion at the end of 2024 provide reasons to remain invested in Jazz Pharmaceuticals [21].

DUBLIN, April 25, 2025 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending the conditional marketing authorization of zanidatamab, an investigational dual human epidermal growth factor receptor 2 (HER2)-targeted bispecific antibody, as monotherapy for the treatment of adults with unresectable locally advanced or metastatic HER2-positive (IHC 3+ ...

Core Insights - Jazz Pharmaceuticals is presenting significant clinical trial data at the ASCO Annual Meeting, highlighting the potential of Zepzelca® (lurbinectedin) in combination with atezolizumab (Tecentriq®) for first-line maintenance therapy in extensive-stage small cell lung cancer (ES-SCLC) [1][2] - The company is also showcasing long-term outcomes for Ziihera® (zanidatamab-hrii) in HER2-positive gastroesophageal cancer, indicating its potential to change treatment paradigms [1][2] - Efficacy and safety data for dordaviprone (ONC201) in recurrent H3 K27M-mutant diffuse glioma patients are also being presented, addressing a significant unmet medical need [1][2] Group 1: Zepzelca® (lurbinectedin) - The Phase 3 IMforte trial data shows statistically significant and clinically meaningful progression-free survival (PFS) and overall survival (OS) for Zepzelca in combination with atezolizumab for ES-SCLC patients [2][4] - The FDA has received a supplemental New Drug Application based on this trial data, marking a milestone for Zepzelca's approval process [2][4] - An investor webcast is scheduled for June 10 to review Zepzelca data, featuring commentary from experts [3] Group 2: Ziihera® (zanidatamab-hrii) - Updated long-term outcomes and median overall survival findings from the Phase 2 trial of Ziihera in combination with chemotherapy for HER2-positive metastatic gastroesophageal adenocarcinoma will be presented [2][4] - Ziihera is positioned as a differentiated HER2-targeted therapy, with further Phase 3 findings expected later this year [2][4] Group 3: Dordaviprone (ONC201) - New efficacy and safety findings for dordaviprone in adult and pediatric patients with recurrent H3 K27M-mutant diffuse glioma are being highlighted [2][4] - The drug addresses a significant unmet need, as there are currently no FDA-approved therapies for this patient population [2][4] Group 4: Company Overview - Jazz Pharmaceuticals is committed to advancing targeted treatment options that address pressing patient needs, with a focus on oncology and neuroscience [55] - The company has a diverse portfolio of marketed medicines and is dedicated to developing potentially life-changing therapies for serious diseases [55]

Group 1 - Jazz Pharmaceuticals plc will report its 2025 first quarter financial results on May 6, 2025, after the U.S. financial markets close [1] - A live audio webcast will be hosted by company management at 4:30 p.m. ET / 9:30 p.m. IST to discuss the financial results and provide a business update [1] - Interested parties can access the live audio webcast via the Investors section of the Jazz Pharmaceuticals website [2] Group 2 - Jazz Pharmaceuticals is a global biopharma company focused on developing life-changing medicines for serious diseases with limited therapeutic options [4] - The company has a diverse portfolio of marketed medicines, including therapies for sleep disorders, epilepsy, and a growing portfolio of cancer treatments [4] - Jazz Pharmaceuticals is headquartered in Dublin, Ireland, with research and development laboratories and manufacturing facilities in multiple countries [4]

Core Insights - Jazz Pharmaceuticals has successfully acquired Chimerix, Inc. for approximately $935 million in cash, enhancing its oncology pipeline and commitment to addressing rare diseases with significant unmet needs [1][2][3] Acquisition Details - The acquisition was completed through a tender offer for Chimerix's outstanding shares at $8.55 per share, which expired on April 17, 2025 [3] - Following the acquisition, Chimerix became a wholly owned subsidiary of Jazz Pharmaceuticals [3] Product Development - The acquisition includes dordaviprone, a novel first-in-class small molecule treatment for H3 K27M-mutant diffuse glioma, which is currently under Priority Review by the FDA with a PDUFA action date set for August 18, 2025 [2][4] - If approved, dordaviprone may be the first FDA-approved therapy for this specific type of glioma and could offer a promising near-term commercial opportunity [2][4] Clinical Trials - Dordaviprone is being evaluated in the ongoing Phase 3 ACTION trial for newly diagnosed, non-recurrent H3 K27M-mutant diffuse glioma patients following radiation treatment, potentially expanding its use into first-line settings [2][4] Company Overview - Jazz Pharmaceuticals is a global biopharmaceutical company focused on developing life-changing medicines for serious diseases, with a diverse portfolio that includes therapies for sleep disorders, epilepsy, and cancer treatments [5]

Core Viewpoint - Jazz Pharmaceuticals and Harmony Biosciences are significant players in the neuroscience sector, particularly in sleep disorders, with Jazz having a more diversified portfolio and stronger financial performance compared to Harmony [1][2][22]. Group 1: Company Overview - Jazz Pharmaceuticals markets several neuroscience drugs, including the oral sleep disorder drug Xywav and the CBD drug Epidiolex, while Harmony Biosciences has one marketed drug, Wakix, for narcolepsy [1][10]. - Jazz derives over two-thirds of its total revenues from its neuroscience franchise, while Harmony generates all its revenue from Wakix sales [3][11]. Group 2: Financial Performance - Jazz's total revenues for 2024 rose 6% year over year to $4.1 billion, with $2.9 billion from neuroscience and $1.1 billion from oncology drugs [9]. - Harmony's 2024 sales increased 23% year over year to $715 million, with expectations for 2025 sales between $820 million and $860 million, indicating an 18% year-over-year growth [11]. Group 3: Product Pipeline and Development - Jazz's Xywav sales rose 16% year over year to $1.5 billion in 2024, and Epidiolex sales increased 15% year over year to $972 million [4][5]. - Harmony is developing next-generation formulations of Wakix and has acquired Zynerba Pharmaceuticals to explore the cannabis space [12][13]. Group 4: Market Position and Valuation - Jazz has a diversified product lineup, including five oncology drugs, which accounted for 29% of its 2024 product revenues [6]. - Harmony's shares trade at a higher price/earnings (P/E) ratio of 8.63 compared to Jazz's 5.07, indicating that Harmony is more expensive [19]. Group 5: Investment Outlook - Jazz is viewed as a better investment option due to its diversified portfolio, rising EPS estimates, and robust cash reserves, while Harmony's reliance on a single product presents a concentration risk [22][23]. - Jazz holds a Zacks Rank 2 (Buy), while Harmony has a Zacks Rank 3 (Hold), reinforcing Jazz's favorable investment standing [24].

Core Viewpoint - Investors are evaluating the value opportunities presented by Jazz Pharmaceuticals (JAZZ) and argenex SE (ARGX), with JAZZ currently appearing to offer superior value based on various valuation metrics [1][7]. Valuation Metrics - JAZZ has a forward P/E ratio of 4.35, significantly lower than ARGX's forward P/E of 46.77, indicating that JAZZ may be undervalued [5]. - The PEG ratio for JAZZ is 0.60, while ARGX has a PEG ratio of 1.44, suggesting that JAZZ has a more favorable growth outlook relative to its valuation [5]. - JAZZ's P/B ratio stands at 1.50, compared to ARGX's P/B of 6.49, further supporting the notion that JAZZ is undervalued relative to its book value [6]. Earnings Outlook - Both JAZZ and ARGX hold a Zacks Rank of 2 (Buy), indicating positive earnings estimate revisions for both companies, which reflects an improving earnings outlook [3].

Company Overview - Jazz Pharmaceuticals (JAZZ) shares increased by 7.1% to close at $110.12, following a significant volume of trading, contrasting with a 24.9% loss over the past four weeks [1] - The rise in share price was influenced by President Trump's announcement of a 90-day pause on tariffs against non-retaliating countries [1] Earnings Expectations - Jazz is projected to report quarterly earnings of $4.65 per share, reflecting a year-over-year increase of 73.5% [2] - Expected revenues for the upcoming quarter are $978.58 million, which is an 8.5% increase compared to the same quarter last year [2] Earnings Estimate Revisions - The consensus EPS estimate for Jazz has been revised 3.2% higher in the last 30 days, indicating a positive trend that typically correlates with stock price appreciation [3] - The stock currently holds a Zacks Rank of 2 (Buy), suggesting favorable market sentiment [3] Industry Context - Jazz operates within the Zacks Medical - Biomedical and Genetics industry, where Novavax (NVAX) also competes [3] - Novavax's consensus EPS estimate has increased by 7.6% over the past month to -$0.43, representing a 59.1% change from the previous year [4] - Novavax currently holds a Zacks Rank of 3 (Hold), indicating a more cautious outlook compared to Jazz [4]

Core Insights - Investors are evaluating Jazz Pharmaceuticals (JAZZ) and argenex SE (ARGX) for potential undervalued stock opportunities in the Medical - Biomedical and Genetics sector [1] Valuation Metrics - JAZZ has a Zacks Rank of 2 (Buy), indicating a stronger earnings outlook compared to ARGX, which has a Zacks Rank of 3 (Hold) [3] - JAZZ's forward P/E ratio is significantly lower at 5.27, while ARGX's forward P/E ratio stands at 47.10 [5] - The PEG ratio for JAZZ is 0.72, suggesting better value relative to its expected earnings growth, compared to ARGX's PEG ratio of 1.45 [5] - JAZZ's P/B ratio is 1.82, indicating a more favorable market value to book value comparison than ARGX's P/B ratio of 6.51 [6] - These metrics contribute to JAZZ receiving a Value grade of A, while ARGX has a Value grade of D [6] Earnings Outlook - JAZZ is noted for its improving earnings outlook, which enhances its attractiveness in the Zacks Rank model [7]

DUBLIN, March 26, 2025 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the Company will participate in the 24th Annual Needham Healthcare Conference. Company management will participate in a fireside chat on Wednesday, April 9, 2025, at 9:45 a.m. PT / 12:45 p.m. ET / 5:45 p.m. IST.An audio webcast of the fireside chat will be available via the Investors section of the Jazz Pharmaceuticals website at https://investor.jazzpharma.com/investors/events-presentations. A replay of the ...