NOT FOR DISTRIBUTION TO UNITED STATES NEWS WIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES VANCOUVER, British Columbia, April 24, 2025 (GLOBE NEWSWIRE) -- Vortex Energy Corp. (CSE: VRTX) (OTC: VTECF) (FSE: AA3) (“Vortex” or the “Company”) announces that it intends to complete a non-brokered private placement financing (the “Private Placement”) consisting of a minimum of 2,190,000 common shares of the Company (the “Common Shares”) and up to a maximum of 4,000,000 Common Shares at an issue price of $0 ...

Each unit consists of one common share in the capital of the company and one common share purchase warrant, with each warrant entitling the holder to acquire one additional common share for a period of 24 months from closing at an exercise price of $0.05. Toronto, Ontario--(Newsfile Corp. - April 14, 2025) - DiagnaMed Holdings Corp. (CSE: DMED) (OTCQB: DGNMF) ("DiagnaMed" or the "Company"), a leading provider of cutting-edge technology solutions for the hydrogen and life sciences industries, is pleased to a ...

Core Points - LithiumBank Resources Corp. has successfully closed the second and final tranche of its non-brokered private placement, raising approximately $2.9 million, bringing total gross proceeds to about $4.9 million [1][5] Group 1: Offering Details - Each LIFE Unit consists of one common share and one-half of a common share purchase warrant, with each warrant allowing the purchase of one share at an exercise price of $0.50 for 36 months [2] - The LIFE Units were issued under the Listed Issuer Financing Exemption, making them immediately tradeable without a hold period under Canadian securities laws [3] Group 2: Finder's Fees and Warrants - The company paid a cash finder's fee of $7,595 to Red Cloud Securities Inc. and issued 21,700 finders' warrants, while also paying $26,464.90 to Leede Financial Inc. and issuing 75,614 finders' warrants [4] Group 3: Use of Proceeds - The net proceeds from the LIFE Offering will be used for brine hosted mineral license payments, environmental assessment studies, and community consultation [5] Group 4: Company Overview - LithiumBank Resources Corp. focuses on lithium exploration in Western Canada, holding 1,855,915 acres of lithium brine licenses across Alberta and Saskatchewan, and has licensed DLE technology from Go2Lithium [7]

LithiumBank Announces Closing of Flow-Through Private Placement & First Tranche of LIFE Private Placement for Aggregate Gross Proceeds of $4,131,000April 07, 2025 8:15 AM EDT | Source: LithiumBank Resources Corp.Vancouver, British Columbia--(Newsfile Corp. - April 7, 2025) -  LithiumBank Resources Corp. (TSXV: LBNK) (OTCQX: LBNKF) ("LithiumBank" or the "Company") is pleased to announce that it has closed its previously announced non-brokered private placement of 5,000,000 flow-through units (t ...

Gunnison Copper Announces Listed Issuer Financing Exemption (LIFE) Private Placement of UnitsMarch 26, 2025 8:00 AM EDT | Source: Gunnison Copper Corp.NOT FOR DISSEMINATION IN THE UNITED STATES OR THROUGH U.S. NEWSWIRE SERVICESPhoenix, Arizona--(Newsfile Corp. - March 26, 2025) - Gunnison Copper Corp. (TSX: GCU) (FSE: 3XS) ("Gunnison" or the "Company") announces a non-brokered private placement (the "Offering") consisting of a minimum of 6,666,700 and up to a maximum of 22,940,000 units (the " ...

Clinical Development - Efzofitimod is a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease (ILD), with orphan drug designations granted by the FDA and European Commission for sarcoidosis and systemic sclerosis (SSc) [21] - The Phase 1b/2a clinical trial demonstrated that efzofitimod was safe and well-tolerated at all doses, with significant improvements in steroid reduction and lung function compared to placebo [22] - The EFZO-FIT study, a pivotal Phase 3 trial for efzofitimod, has enrolled 268 patients, exceeding the target of 264, with topline data expected in Q3 2025 [24] - The company has initiated an Individual Patient Expanded Access Program for efzofitimod, allowing patients who completed the EFZO-FIT study to receive treatment outside of the clinical trial [25] - The EFZO-CONNECT study is underway to evaluate efzofitimod in patients with SSc-ILD, with interim data expected in Q2 2025 [26] - The primary endpoint of the EFZO-FIT study is steroid reduction, with secondary endpoints including lung function assessed by FVC and health-related quality of life [52] - The Phase 3 EFZO-FIT study enrolled 268 adults with pulmonary sarcoidosis, exceeding the target enrollment of 264 patients [54] - The EFZO-FIT study was initiated in Q3 2022, focusing on steroid reduction as the primary endpoint for FDA approval in pulmonary sarcoidosis [161] - The EFZO-CONNECT study, a Phase 2 trial for SSc-ILD, is expected to enroll up to 25 patients and report interim data in Q2 2025 [63] Mechanism of Action - Efzofitimod acts as a selective modulator of NRP2, downregulating innate immune responses to resolve chronic inflammation and prevent fibrosis [34] - Efzofitimod has shown significant reduction in lung inflammation and fibrosis in animal models, improving respiratory function parameters [39] - Efzofitimod targets immune cells of myeloid lineage, modulating inflammatory responses and potentially reducing the need for oral corticosteroids [49] - In preclinical studies, efzofitimod has demonstrated downregulation of inflammatory cytokines such as IL-6 and MCP-1 in both animal models and human trials [51] - Efzofitimod is a fusion protein that selectively binds to the NRP2 receptor, which is upregulated during myeloid cell activation [42] Financial and Market Considerations - The global market opportunity for efzofitimod in pulmonary sarcoidosis and SSc-ILD is estimated to be between $2 billion and $5 billion [78] - The company has approximately $75.1 million in cash, cash equivalents, restricted cash, and available-for-sale investments as of December 31, 2024, which is expected to meet material cash requirements for at least one year [205] - The company incurred consolidated net losses of $64.0 million for the year ended December 31, 2024, with an accumulated deficit of $532.0 million as of the same date [211] - The company has not generated any revenue from product sales since its inception in 2005 and does not anticipate doing so for the foreseeable future [215] - The company is eligible to receive up to an additional $155.0 million in milestone payments under the Kyorin Agreement, along with tiered royalties ranging from mid-single digits to mid-teens on net sales in Japan [217] - The company has received $20.0 million in upfront and milestone payments from Kyorin to date, but future payments depend on Kyorin's development and commercialization efforts [218] Regulatory and Compliance - Regulatory compliance is critical, as failure to meet FDA requirements could result in sanctions that adversely affect the company [103] - The IND submission must include extensive preclinical testing results, including animal and in vitro studies, to assess toxicology and pharmacological characteristics [105] - The FDA may impose a clinical hold at any time during a clinical trial, which could limit trial parameters such as dosage or timeframe [106] - A BLA must include all relevant data from preclinical studies and clinical trials, and the FDA must determine the safety and effectiveness of the product before approval [112] - The FDA typically conducts a pre-approval inspection of manufacturing facilities to ensure compliance with cGMP requirements before approving a BLA [113] - The FDA may grant Fast Track designation for drugs addressing serious conditions, allowing for more frequent interactions and priority review [117] - Under the accelerated approval program, the FDA may approve a BLA based on surrogate endpoints that predict clinical benefit [118] - Orphan drug designation provides financial incentives and exclusivity for drugs treating rare diseases, preventing approval of similar drugs for seven years [126] - The company must obtain requisite approvals from regulatory authorities in foreign countries prior to commencing clinical trials or marketing products [132] - The company is subject to various federal and state laws targeting fraud and abuse in the healthcare industry, which may impact sales and marketing programs [140] Challenges and Risks - The company has faced delays in clinical trials due to challenges such as patient enrollment and compliance with study protocols, which could impact the timeline for obtaining regulatory approval [154] - The company may encounter difficulties in enrolling patients for clinical trials due to the limited number of patients with the diseases being studied [166] - The occurrence of adverse events or negative perceptions from clinical trials could necessitate additional trials or delay marketing approval [156] - The integrity of clinical trial data may be compromised by factors such as patient dropout rates and external geopolitical events [158] - The company may face challenges related to CDMO manufacturing stoppages and compliance with extensive regulations governing the production of therapeutics [174] - The company may need to raise additional capital or enter into strategic partnerships to fund operations due to the high costs associated with therapeutic development [205] - Public perception of safety issues may adversely influence participation in clinical trials and the adoption of new therapeutics by healthcare providers [199] Product Development Pipeline - The company is developing a diverse pipeline of biologics product candidates based on tRNA synthetase biology, with two programs, ATYR0101 and ATYR0750, in preclinical development [33] - ATYR0101, derived from aspartyl-tRNA synthetase, is believed to have broad therapeutic applications in multiple fibrotic diseases [71] - ATYR0750, derived from alanyl-tRNA synthetase, is a novel ligand to FGFR4, which may lead to improved therapeutic benefits in inflammation and fibrosis [72] - The company is focusing on developing product candidates based on extracellular tRNA synthetase biology, with ongoing preclinical studies for ATYR0101 and ATYR0750 [195] Corporate Structure and Operations - The company aims to transition from a clinical stage biotech to a commercial pharmaceutical company, focusing on pre-commercialization efforts in the U.S. market [31] - The company has over 300 issued patents or allowed patent applications, with expiration dates ranging from 2026 to 2034 [87] - The efzofitimod patent portfolio includes issued patents in multiple countries, with U.S. patents expected to expire between 2030 and 2031 [93] - The company relies on contract manufacturing organizations (CDMOs) for the production of efzofitimod, which is cost-efficient and eliminates the need for direct investment in manufacturing facilities [82] - The company plans to invest significant financial and management resources to develop the commercial infrastructure necessary for product entry [81] - The company operates in a highly competitive biotechnology industry, making talent acquisition and retention crucial for executing its strategy [146] - The company has a Code of Business Conduct and Ethics to ensure core values are applied throughout its operations [147]

Financial Performance - Total revenues for the year ended 2024 were $0.235 million, a decrease from $0.353 million in 2023[15]. - The consolidated net loss for the year ended 2024 was $64.0 million, compared to a net loss of $50.4 million in 2023[15]. - Research and development expenses for the year ended 2024 were $54.4 million, primarily for clinical trial costs[8]. - General and administrative expenses for the year ended 2024 were $13.8 million[8]. Cash and Assets - Cash and cash equivalents as of December 31, 2024, were $75.1 million, with an additional $18.8 million raised post-Q4 2024[8]. - Total assets decreased from $120,653 million in 2023 to $96,830 million in 2024, representing a decline of approximately 19.7%[17]. - Cash and cash equivalents dropped from $101,650 million in 2023 to $75,076 million in 2024, a decrease of about 26.1%[17]. - Total stockholders' equity fell from $90,470 million in 2023 to $69,832 million in 2024, reflecting a decline of approximately 22.8%[17]. - Accounts payable and accrued expenses decreased from $15,088 million in 2023 to $13,715 million in 2024, a reduction of about 9.1%[17]. - Long-term operating lease liability, net of current portion, decreased from $12,339 million in 2023 to $11,144 million in 2024, a decline of approximately 9.7%[17]. - Prepaid expenses and other assets increased significantly from $2,521 million in 2023 to $8,159 million in 2024, an increase of about 223.5%[17]. - Current portion of financing lease liability increased from $497 million in 2023 to $541 million in 2024, an increase of approximately 8.8%[17]. - Current portion of operating lease liability decreased from $831 million in 2023 to $711 million in 2024, a reduction of about 14.4%[17]. - Other receivables decreased from $2,436 million in 2023 to $1,736 million in 2024, a decline of approximately 28.8%[17]. - Financing lease right-of-use assets decreased from $1,788 million in 2023 to $1,192 million in 2024, a decline of about 33.4%[17]. Clinical Trials - Topline data from the Phase 3 EFZO-FIT™ study of efzofitimod in pulmonary sarcoidosis is expected in Q3 2025[1]. - The Phase 3 EFZO-FIT™ study enrolled 268 patients across 85 centers in nine countries, with a total of 12 doses administered[5]. - The fourth positive DSMB review for efzofitimod confirmed its favorable safety profile, allowing the study to continue as designed[4]. - Interim data from the Phase 2 EFZO-CONNECT™ study is expected in Q2 2025, focusing on skin assessments in approximately 8 patients[6]. Financial Guidance - The company updated its financial guidance, indicating sufficient cash runway for one year following the Phase 3 EFZO-FIT™ readout[8].

Dividend Announcement - Globe Life Inc. has raised its quarterly dividend to $0.2700 per share for all outstanding common stock, with a record date of April 3, 2025, and payment scheduled for May 1, 2025 [1] Board of Directors Appointments - Matthew J. Adams and Philip M. Jacobs have been appointed as new members of Globe Life's Board of Directors on February 26, 2025 [2] Matthew J. Adams' Background - Adams has over 30 years of experience at PricewaterhouseCoopers LLP, including roles as U.S. Insurance Practice Leader, with expertise in strategy, operations, profitability, and insurance financial reporting [3] Philip M. Jacobs' Background - Jacobs brings over 35 years of experience in insurance, banking, and professional services, with significant expertise in accounting and taxation within the financial services industry, particularly in life insurance [4] Company Overview - Globe Life Inc. specializes in life and supplemental health insurance for the middle-income market, utilizing multiple distribution channels including direct-to-consumer and agency models [5]

Core Points - DiagnaMed Holdings Corp. is arranging a private placement of units with a minimum of $350,000 and a maximum of $510,000 at a price of $0.03 per unit [1][2] - Each unit consists of one common share and one common share purchase warrant, allowing the holder to acquire an additional common share at $0.05 for 24 months [2] - The net proceeds from the offering will be used for research, development, and commercialization of hydrogen production technology and the BRAIN AGE® Brain Health AI Platform [4] Offering Details - The offering may include finder's fees of up to 8% of gross proceeds and non-transferable finder warrants [5] - Up to 17,000,000 units may be issued under the Listed Issuer Financing Exemption, with no resale restrictions [6] - The anticipated closing date for the offering is on or about March 31, 2025, subject to regulatory approvals [7] Company Overview - DiagnaMed Holdings Corp. focuses on innovative technology solutions in the cleantech and life sciences sectors, particularly in hydrogen production and AI-driven drug discovery [8]

Core Viewpoint - American Tungsten Corp. is proceeding with a non-brokered private placement to raise $2,000,000 through the sale of 1,250,000 common shares at a price of $1.60 per share [1][4]. Group 1: Offering Details - The private placement is conducted under the Listed Issuer Financing Exemption, allowing it to be offered to purchasers in all Canadian provinces except Quebec [2]. - The securities offered will not be subject to a hold period under Canadian securities laws [2]. - The offering may close in one or more tranches and is contingent upon raising a minimum of $2,000,000 in gross proceeds [4]. Group 2: Use of Proceeds - The net proceeds from the offering will be allocated for property payments, property exploration, marketing, and general working capital [3]. Group 3: Finder's Fees - The company will pay finders' fees of up to 7.0% of the gross proceeds raised and issue non-transferable finders' warrants equivalent to 7.0% of the number of shares sold [5]. Group 4: Company Background - American Tungsten Corp. is involved in the acquisition and exploration of mineral properties, including the Star Project in British Columbia and the IMA Mine Project in Idaho [7].