Start Time: 16:30 January 1, 0000 5:12 PM ET MaxCyte, Inc. (NASDAQ:MXCT) Q4 2024 Earnings Conference Call March 11, 2025, 16:30 PM ET Company Participants Maher Masoud - President and CEO Doug Swirsky - CFO Erik Abdo - IR Conference Call Participants Matt Larew - William Blair Julie Simmonds - Panmure Liberum Brendan Smith - TD Cowen Mark Massaro - BTIG Matt Hewitt - Craig-Hallum Operator Thank you for standing by and welcome to MaxCyte's Fourth Quarter Earnings Conference Call. At this time, all participan ...

Financial Performance - The company reported net losses of $41.1 million and $37.9 million for the years ended December 31, 2024 and 2023, respectively, with an accumulated deficit of $216.9 million as of December 31, 2024[127]. - Research and development expenses for the years ended December 31, 2024 and 2023 were $22.2 million and $23.8 million, respectively, representing approximately 58% of total revenue[164]. - A significant portion of revenue is derived from sales of products that require functioning instruments, and failures could lead to lost revenue and damaged reputation[238]. - The company may experience significant fluctuations in operating results, making future predictions difficult[278]. Revenue Sources and Customer Dependency - Sales and licensing of the ExPERT technology platform accounted for 45% of the company's revenue for the years ended December 31, 2024 and 2023[133]. - Two cell therapy companies accounted for 32% of total revenue for the year ended December 31, 2024, while the five largest customers contributed approximately 46% of total revenue[196]. - The company relies heavily on milestone payments, which are contingent on the successful development and commercialization of therapies by its partners[197]. - The company’s revenue is significantly influenced by research and development spending by biopharmaceutical companies, which may be affected by market conditions and budgetary constraints[159]. Growth Strategy and Market Expansion - The company plans to invest in technology and scientific innovation, broaden distribution capabilities, and pursue strategic partnerships and acquisitions to grow its market opportunity[138]. - The company intends to expand its international operations, which involves navigating complex foreign regulatory requirements[141]. - The company aims to sell its recently launched ExPERT VLx platform for large-scale bioprocessing applications, which may require additional investment and could face delays in customer acceptance[139]. - The company is committed to developing applications within life sciences and biotechnology, targeting significant revenue opportunities in cell-based therapeutics and drug discovery[231]. Operational Challenges - The company faces challenges in increasing market penetration and expanding into adjacent markets, which are critical for improving operating results[145][146]. - The company may face challenges in managing international operations due to varying legal, regulatory, and economic conditions[169]. - The company faces risks related to the management and integration of licensing arrangements and collaborations, which may disrupt operations and affect profitability[201]. - The company faces intense competition for skilled personnel, which may limit its ability to hire and retain qualified employees[308]. Regulatory and Compliance Risks - Regulatory authorities have substantial discretion in the approval process, which could delay or prevent the commercialization of products developed using the company's platform[190]. - The company is subject to stringent data privacy and security laws, and noncompliance could result in significant penalties and reputational harm[253]. - The company is subject to various data privacy and security laws, including the EU GDPR and UK GDPR, which impose potential fines of up to €20 million or 4% of total worldwide annual turnover, whichever is higher[255]. - The company is subject to anti-corruption and anti-money laundering laws, which could result in substantial civil and criminal penalties for violations[263]. Supply Chain and Manufacturing Risks - The company relies on a limited number of suppliers for key components, with approximately 16% of inventory additions in 2024 sourced from a single supplier, which poses risks of shortages and delays[210]. - The company does not have long-term supply contracts, making it vulnerable to prioritization by suppliers for other customers, which could lead to supply chain disruptions[211]. - Manufacturing of PAs began in-house in 2022, but the company expects to continue outsourcing a portion of production, which may affect supply reliability[219]. - The company relies heavily on third-party manufacturing organizations, and any disruptions in their operations could impair the ability to sell products[288]. Cybersecurity and Data Privacy - Cybersecurity threats are increasing, with risks including ransomware attacks and supply-chain vulnerabilities that could disrupt operations and lead to significant financial losses[293]. - The company has invested significantly in security measures, but there is no assurance that these efforts will prevent service interruptions or security incidents[300]. - The company relies on a third-party Managed Services Provider (MSP) for cybersecurity risk management, which operates a 24/7 security operations center (SOC) to monitor devices and networks for malicious activity[304]. - The company’s contracts may not sufficiently protect against liabilities related to data privacy and security obligations, and insurance coverage may not be adequate to mitigate potential claims[303]. Economic and Market Conditions - The company anticipates that geopolitical tensions, such as the conflict between Russia and Ukraine, could adversely affect its supply chain and global operations[167]. - Economic conditions, including inflation and market volatility, could materially affect the company's results of operations and liquidity needs[276]. - Changes in tariffs and trade policies may adversely affect sales and profitability, particularly in the context of U.S.-China trade relations[249]. - The Federal Reserve lowered interest rates three times during 2024 after significant increases in 2022 and 2023, which may impact the company's operations and liquidity[276]. Human Resources and Organizational Growth - The company has 114 full-time employees as of December 31, 2024, and anticipates further growth in personnel to support sales and marketing strategies[314]. - Future growth may strain the company's organizational and operational infrastructure, necessitating improvements in quality control, finance, and customer service management[315]. - Hiring and training qualified personnel is critical, as competition for skilled application scientists is intense due to rapid growth in the cell therapy field[244]. - The company emphasizes the need to expand its sales and application scientist infrastructure to drive adoption of its products in new markets[239].

Financial Results - MaxCyte, Inc. announced preliminary unaudited financial results for Q4 and fiscal year ended December 31, 2024[4]. - The press release detailing financial results was issued on January 13, 2025[4]. Company Classification - The company is classified as an emerging growth company under the Securities Act[3].

Core Insights - MaxCyte reported strong financial results for 2024, highlighting a return to core revenue growth and disciplined cash management, with a focus on long-term value creation for shareholders [3][5][12] - The company signed a record six Strategic Platform Licenses (SPLs) in 2024 and anticipates continued momentum in the SPL pipeline [3][5] - MaxCyte aims to position itself as a premier cell engineering solutions provider through strategic initiatives and investments, including the integration of SeQure Dx [3][16] Financial Performance - Total revenue for Q4 2024 was $8.7 million, a decrease of 45% compared to Q4 2023, primarily due to one-time approval milestones in the previous year [5][7] - Core business revenue for Q4 2024 was $8.6 million, an increase of 20% year-over-year [5][8] - For the full year 2024, total revenue was $38.6 million, down 6% from 2023, while core business revenue increased by 9% to $32.5 million [12][14] Revenue Breakdown - SPL Program-related revenue for Q4 2024 was $0.1 million, significantly lower than $8.5 million in Q4 2023 [5][8] - For the full year 2024, SPL Program-related revenue was $6.1 million, down from $11.5 million in 2023 [12][14] - The company ended 2024 with 28 active SPL agreements, including 18 active clinical programs [5][6] Profitability Metrics - Gross profit for Q4 2024 was $6.4 million, with a gross margin of 74%, compared to a gross margin of 90% in Q4 2023 [9][11] - For the full year 2024, gross profit was $31.5 million, yielding an 82% gross margin, down from 89% in 2023 [13][14] - Operating expenses for Q4 2024 were $19.3 million, a decrease from $22.2 million in Q4 2023 [10][11] Cash Position - As of December 31, 2024, total cash, cash equivalents, and investments were $190.3 million, down from $211.2 million at the end of 2023 [15][16] - The company expects to end 2025 with $160 million in total cash, cash equivalents, and investments [16][22] 2025 Guidance - MaxCyte anticipates core revenue growth of 8% to 15% compared to 2024, including revenue from SeQure Dx [22] - SPL Program-related revenue is projected to be approximately $5 million for 2025 [22]

Core Insights - MaxCyte, Inc. has entered into a strategic platform license agreement with TG Therapeutics, allowing TG Therapeutics to utilize MaxCyte's Flow Electroporation® technology and ExPERT™ platform for research, clinical, and commercial purposes [1][2] - In exchange, MaxCyte will receive annual licensing fees and program-related revenue from TG Therapeutics [2] - TG Therapeutics is advancing its investigational allogeneic CD19 CAR T cell therapy, azer-cel, for autoimmune diseases, with plans to commence a Phase 1 trial in 2025 [3][4] Company Overview: MaxCyte - MaxCyte specializes in cell engineering technologies aimed at enhancing the discovery and commercialization of cell-based therapeutics [1] - The ExPERT™ platform is designed to support the growing cell therapy market, providing high transfection efficiency and scalability [4][5] - MaxCyte has over 25 years of experience in developing advanced platforms and technologies for cell therapy applications [5] Company Overview: TG Therapeutics - TG Therapeutics focuses on developing and commercializing novel treatments for B-cell diseases, including a pipeline of investigational medicines [6] - The company has received FDA approval for BRIUMVI® (ublituximab-xiiy) for treating relapsing forms of multiple sclerosis [6]

Core Insights - MaxCyte, Inc. will release its financial results for Q4 and full year 2024 on March 11, 2025, after U.S. market close [1] - A conference call to discuss these results will be held at 4:30 p.m. Eastern Time on the same day [1] Earnings Conference Call Details - Investors must register online to listen to the conference call, with a recommendation to register at least a day in advance [2] - A live and archived webcast of the conference call will be available on MaxCyte's investor relations website [2] - Company management will also participate in the 45th Annual TD Cowen Healthcare Conference on March 3, 2025, at 10:30 a.m. ET [2] About MaxCyte - MaxCyte focuses on cell engineering to enhance patient outcomes, with over 25 years of expertise in developing advanced platforms [3] - The ExPERT™ platform, utilizing Flow Electroporation® technology, supports the growing cell therapy market from discovery to commercialization [3] - The ExPERT product family includes four instruments and a range of proprietary processing assemblies and software protocols, backed by a strong intellectual property portfolio [3]

Core Viewpoint - MaxCyte, Inc. has announced the acquisition of SeQure Dx, enhancing its capabilities in cell and gene therapy development and commercialization [1][2] Group 1: Acquisition Details - MaxCyte acquired SeQure Dx for an initial cash consideration of $4.5 million, with potential contingent payments up to $2.5 million based on revenue targets [6] - SeQure Dx generated approximately $1.7 million in revenue and incurred a loss of about $6.5 million in 2024 [6] - The acquisition is expected to be accretive to MaxCyte's revenue growth and improve operational efficiencies [2][7] Group 2: Strategic Importance - The acquisition strengthens MaxCyte's service offerings for ex vivo and in vivo cell and gene therapy developers, providing innovative tools and services from early R&D to commercialization [2][3] - SeQure Dx specializes in precise editing confirmation and risk assessment for off-target effects, crucial for regulatory success in gene therapies [3][4] - The integration of SeQure Dx is aimed at enhancing safety and precision in cell therapies, aligning with MaxCyte's commitment to advancing cell engineering [4][5] Group 3: Company Background - SeQure Dx, co-founded by Dr. Keith Joung, emerged from stealth mode in late 2022 and offers a comprehensive portfolio of evaluation assays for off-target risk validation [4][10] - MaxCyte has over 25 years of experience in cell engineering, focusing on developing platforms that support the cell therapy market [9]

Core Viewpoint - MaxCyte, Inc. (MXCT) has received an upgrade to a Zacks Rank 1 (Strong Buy) due to an upward trend in earnings estimates, which is a significant factor influencing stock prices [1][3]. Earnings Estimates and Stock Performance - The Zacks rating system is based on changes in earnings estimates, which are closely correlated with near-term stock price movements [4][6]. - Rising earnings estimates for MaxCyte indicate an improvement in the company's underlying business, likely leading to increased stock prices [5][10]. Zacks Rank System - The Zacks Rank system classifies stocks into five groups based on earnings estimates, with Zacks Rank 1 stocks historically generating an average annual return of +25% since 1988 [7][9]. - Only the top 5% of Zacks-covered stocks receive a 'Strong Buy' rating, indicating superior earnings estimate revisions [9][10]. Recent Earnings Estimate Revisions - For the fiscal year ending December 2024, MaxCyte is expected to earn -$0.42 per share, reflecting a change of -13.5% from the previous year [8]. - Over the past three months, the Zacks Consensus Estimate for MaxCyte has increased by 0.8%, indicating positive sentiment among analysts [8].

Core Insights - MaxCyte, Inc. provided a preliminary update on its financial results for Q4 and the full year 2024, indicating a positive outlook for the cell therapy industry as it moves into 2025 [1][4]. Financial Performance - Total cash, cash equivalents, and investments as of December 31, 2024, are expected to be approximately $190 million, a decrease from $211 million on December 31, 2023, but higher than the updated guidance of $185 million [3]. - Core revenue for Q4 2024 is expected to be between $8.3 million and $8.5 million, compared to $7.2 million in Q4 2023 [6]. - Core revenue for the full year 2024 is expected to be between $32.2 million and $32.4 million, representing an 8 to 9% growth compared to $29.8 million for fiscal year 2023 [6]. Business Developments - The company increased the number of SPL customers by six in 2024 and supported the commercial launch of the first non-viral gene-edited cell therapy product approved by the FDA [4]. - MaxCyte's ExPERT™ platform is designed to support the expanding cell therapy market, facilitating the discovery, development, and commercialization of next-generation cell-based medicines [5].

Core Insights - MaxCyte, Inc. announced the retirement of Art Mandell from its Board of Directors effective December 31, 2024, after serving since 2006, contributing significantly to the company's growth and strategic direction [8][4][9] Company Overview - MaxCyte focuses on cell engineering, providing platform technologies to enhance the discovery, development, and commercialization of next-generation cell therapeutics [8] - The company has developed the ExPERT™ platform, which utilizes Flow Electroporation® technology, aimed at supporting the expanding cell therapy market [8][4] - The ExPERT family includes four instruments (ATx™, STx™, GTx™, VLx™), proprietary processing assemblies, and software protocols, backed by a strong intellectual property portfolio [8] Achievements - Under Mr. Mandell's leadership, MaxCyte achieved key milestones such as its initial public offering on the UK AIM exchange and US Nasdaq listing, the launch of the ExPERT™ platform, and signing 29 Strategic Platform Licenses with biotech companies [4][8] - The company also supported the first FDA-approved CRISPR edited non-viral cell therapy in the industry [4]