It has been about a month since the last earnings report for Nektar Therapeutics (NKTR) . Shares have lost about 38.8% in that time frame, underperforming the S&P 500.Will the recent negative trend continue leading up to its next earnings release, or is Nektar due for a breakout? Before we dive into how investors and analysts have reacted as of late, let's take a quick look at its most recent earnings report in order to get a better handle on the important catalysts.How Have Estimates Been Moving Since Then ...

Company Overview - Nektar Therapeutics is a clinical-stage biotechnology company focused on developing treatments for autoimmune and chronic inflammatory diseases [3] - The company's lead product candidate, rezpegaldesleukin (REZPEG or NKTR-358), is a first-in-class regulatory T cell stimulator currently in two Phase 2b clinical trials for atopic dermatitis and alopecia areata [3] - Nektar's pipeline includes a preclinical bivalent tumor necrosis factor receptor type II (TNFR2) antibody, bispecific programs NKTR-0165 and NKTR-0166, and a modified hematopoietic colony stimulating factor (CSF) protein, NKTR-422 [3] - The company is also evaluating NKTR-255, an investigational IL-15 receptor agonist aimed at enhancing the immune system's ability to combat cancer, in several ongoing clinical trials [3] Upcoming Events - Nektar Therapeutics will participate in the H.C. Wainwright 3rd Annual Autoimmune & Inflammatory Disease Virtual Conference on March 27, 2025, at 2:00 p.m. Eastern Time [1] - The fireside chat will be accessible via a webcast link and will also be available for replay for 30 days [1] Investor Relations - Investors interested in one-on-one meetings with company management during the conference can contact their respective H.C. Wainwright representative [2]

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 Form 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. For the fiscal year ended December 31, 2024 or ☐ TRANSITION REPORTS PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. For the transition period from to Commission File Number: 0-24006 NEKTAR THERAPEUTICS (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation ...

Core Viewpoint - Nektar Therapeutics reported a quarterly loss of $0.15 per share, missing the Zacks Consensus Estimate of a loss of $0.13 per share, and showing an improvement from a loss of $0.22 per share a year ago [1] Financial Performance - The company posted revenues of $29.18 million for the quarter ended December 2024, missing the Zacks Consensus Estimate by 25.23%, but showing an increase from year-ago revenues of $23.89 million [2] - Nektar's earnings surprise was -15.38%, and it had previously reported a loss of $0.18 per share against an expected loss of $0.23 per share, resulting in a surprise of 21.74% [1][3] Stock Performance - Nektar shares have declined approximately 11.9% since the beginning of the year, compared to a decline of 5.3% for the S&P 500 [3] - The company's current consensus EPS estimate for the upcoming quarter is -$0.19 on revenues of $20.72 million, and for the current fiscal year, it is -$0.80 on revenues of $76.8 million [7] Industry Outlook - The Medical - Drugs industry, to which Nektar belongs, is currently ranked in the top 35% of over 250 Zacks industries, indicating a favorable outlook [8] - Empirical research suggests a strong correlation between near-term stock movements and trends in earnings estimate revisions, which can impact Nektar's stock performance [5][6]

Nektar Therapeutics (NKTR) incurred an adjusted loss per share of 15 cents in the fourth quarter of 2024, wider than the Zacks Consensus Estimate of a loss of 13 cents. In the year-ago quarter, the company had incurred a loss of 22 cents per share.See the Zacks Earnings Calendar to stay ahead of market-making news.Total revenues in the fourth quarter increased 22.2% year over year to $29.2 million. The reported figure however missed the Zacks Consensus Estimate of $39 million.In the past year, shares of Nek ...

Financial Data and Key Metrics Changes - The company ended 2024 with $269.1 million in cash and investments, with no debt on the balance sheet [34] - Revenue for Q4 2024 was $29.2 million, and for the full year 2024, it was $98.4 million [35] - R&D expenses for Q4 were $28.7 million, totaling $120.9 million for the full year [35] - The net income for Q4 was $7.3 million, translating to $0.03 basic and diluted earnings per share, while the full year net loss was $119 million or $0.58 basic and diluted loss per share [35] Business Line Data and Key Metrics Changes - The company completed enrollment for its Phase IIb studies in atopic dermatitis and alopecia areata, with the RESOLVE AD trial enrolling 400 patients and the RESOLVE AA study enrolling 90 patients [6][7] - The RESOLVE AD study is designed to evaluate three different dosing regimens of Respegg, with a focus on pharmacodynamic profiles [19][20] Market Data and Key Metrics Changes - In the U.S., over 15 million people suffer from moderate to severe atopic dermatitis, with less than 10% receiving biologic treatments [8] - The treatment market for alopecia areata is estimated to reach $5.2 billion in the U.S. and Europe by 2023 [9] Company Strategy and Development Direction - The company aims to provide a more durable treatment option for atopic dermatitis and alopecia areata through its novel immunomodulating mechanism, Respegg [10] - The company is expanding its preclinical pipeline in immunology and inflammation, including a novel TNFr2 agonist antibody program [11][12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the upcoming data catalysts for Respegg in 2025, highlighting the enthusiasm from patients and physicians for its novel mechanism of action [6][7] - The company remains in a strong financial position, with a cash runway extending into Q4 2026 [13][36] Other Important Information - The company recognized a gain of $40.4 million from the sale of its Huntsville manufacturing facility [35] - The company plans to end 2025 with approximately $100 million in cash and investments [36] Q&A Session Summary Question: What are the expectations for dose responses across the three dose arms? - The company designed the study with three cohorts to evaluate different dose levels and regimens, focusing on pharmacodynamic profiles [42][43] Question: What is the efficacy bar for advancing Respegg into pivotal development? - The company aims to replicate the Phase 1b results, with efficacy comparable to Dupixent being a successful outcome [48][51] Question: What updates are there on the interim PFS results from the Javelin bladder medley study? - Results are expected around the middle of the year, with the goal to improve PFS compared to single-agent Bavencio [66] Question: How does the company expect the patient baseline to compare to recent trials? - The company aims for baseline EASI scores in the range of 25 to 30 to minimize placebo response rates [71] Question: Can you elaborate on the escape arm structure in the protocol? - Patients not meeting EASI 50 criteria at the end of induction can enter an escape arm for additional treatment options [80]

Core Insights - Nektar Therapeutics reported a revenue of $29.18 million for the quarter ended December 2024, reflecting a year-over-year increase of 22.1% [1] - The earnings per share (EPS) was $0.15, a significant improvement from -$0.22 in the same quarter last year, resulting in an EPS surprise of +215.38% compared to the consensus estimate of -$0.13 [1] - The reported revenue fell short of the Zacks Consensus Estimate of $39.02 million by 25.23% [1] Revenue Breakdown - Product sales reached $12.87 million, exceeding the average estimate of $9.76 million from eight analysts, marking a year-over-year increase of 134.8% [4] - Non-cash royalty revenue related to future royalties was $16.24 million, slightly above the estimated $15.15 million, but showed a decline of 10.1% compared to the previous year [4] - License, collaboration, and other revenue was only $0.06 million, significantly below the average estimate of $28.26 million from four analysts, representing a year-over-year decrease of 81.5% [4] Stock Performance - Nektar's shares have returned +23.5% over the past month, contrasting with a -8.2% change in the Zacks S&P 500 composite [3] - The stock currently holds a Zacks Rank 2 (Buy), suggesting potential for outperformance in the near term [3]

Financial Performance - Revenue for Q4 2024 was $29.2 million, a 22.1% increase from $23.9 million in Q4 2023[4] - Net income for Q4 2024 was $7.3 million, compared to a net loss of $42.1 million in Q4 2023[9] - The net loss for the full year 2024 was $119.0 million, an improvement from a net loss of $276.1 million in 2023[9] - The company reported a net income of $7,261,000 in Q4 2024, a turnaround from a net loss of $42,079,000 in Q4 2023[22] - Basic net income per share improved to $0.03 in Q4 2024, compared to a loss of $0.22 per share in Q4 2023[22] Operating Costs and Expenses - Total operating costs and expenses for Q4 2024 were $14.8 million, significantly down from $57.4 million in Q4 2023, primarily due to a $40.4 million gain from the sale of the Huntsville manufacturing facility[5] - G&A expenses for the full year 2024 were $76.8 million, slightly down from $77.4 million in 2023, indicating cost management efforts[7] Research and Development - R&D expenses for the full year 2024 were $120.9 million, up from $114.2 million in 2023, driven by increased development expenses for rezpegaldesleukin[6] - Research and development expenses for the year totaled $120,908,000, up from $114,162,000 in 2023, marking a 6% increase[22] - The company completed enrollment for the Phase 2b trials of rezpegaldesleukin in atopic dermatitis and alopecia areata, with topline data expected in Q2 and Q4 2025, respectively[3] - Nektar plans to submit the IND for NKTR-0165 in the second half of 2025, expanding its immunology pipeline[3] Sales and Revenue Growth - Product sales increased significantly to $12,874,000 in Q4 2024, compared to $5,483,000 in Q4 2023, representing a 134% growth[22] - Total revenue for Q4 2024 reached $29,175,000, a 22% increase from $23,885,000 in Q4 2023[22] Assets and Liabilities - Total assets decreased to $303,850,000 in 2024 from $398,033,000 in 2023, reflecting a 24% decline[20] - Total liabilities were reduced to $243,113,000 in 2024, down from $267,046,000 in 2023, indicating a 9% decrease[20] - Total stockholders' equity decreased to $60,737,000 in 2024 from $130,987,000 in 2023, a decline of 53%[20] Other Significant Events - Nektar announced a definitive agreement to sell its commercial PEGylation manufacturing business for $90 million, which includes $70 million in cash[12] - The FDA granted Fast Track designation for rezpegaldesleukin for treating moderate-to-severe atopic dermatitis in patients aged 12 and older[11] - The company recorded a gain of $40,390,000 from the sale of the Huntsville manufacturing facility in Q4 2024[22] - Non-cash royalty revenue related to future royalties was $16,238,000 in Q4 2024, slightly down from $18,061,000 in Q4 2023[22]

Core Insights - Nektar Therapeutics reported a net income of $7.3 million for Q4 2024, a significant improvement from a net loss of $42.1 million in Q4 2023, indicating a positive shift in financial performance [8] - The company achieved total revenue of $29.2 million in Q4 2024, up from $23.9 million in Q4 2023, and a total annual revenue of $98.4 million for 2024, compared to $90.1 million in 2023, reflecting growth in product sales and other revenue streams [3][14] - Nektar's cash and investments in marketable securities decreased to $269.1 million as of December 31, 2024, from $329.4 million a year earlier, but are expected to support operations until Q4 2026 [1] Financial Performance - Total operating costs and expenses for Q4 2024 were $14.8 million, significantly lower than $57.4 million in Q4 2023, primarily due to a $40.4 million gain from the sale of the Huntsville manufacturing facility [4][15] - Research and development (R&D) expenses for Q4 2024 were $28.7 million, slightly down from $29.9 million in Q4 2023, while total R&D expenses for the year increased to $120.9 million from $114.2 million in 2023 [5][14] - General and administrative (G&A) expenses remained stable at $17.1 million for Q4 2024 compared to $17.3 million in Q4 2023, with total G&A expenses for the year at $76.8 million, down from $77.4 million in 2023 [6][14] Business Developments - Nektar is advancing its immunology pipeline, with two Phase 2b trials for rezpegaldesleukin now fully enrolled, expecting topline data in Q2 and Q4 2025 [2] - The company reported progress in preclinical programs, including the first data for NKTR-0165 and the introduction of a new bispecific antibody, NKTR-0166, with plans to submit an IND for NKTR-0165 in the second half of 2025 [2] - Nektar's lead product candidate, rezpegaldesleukin, is being evaluated for chronic autoimmune disorders, positioning the company for potential value creation in the upcoming year [2][11]

Core Insights - Nektar Therapeutics will announce its financial results for Q4 and the full year ended December 31, 2024, on March 12, 2025, after U.S. market close [1] - The conference call to discuss the results will be hosted by Howard Robin, President and CEO, at 5:00 p.m. Eastern Time [1] Company Overview - Nektar Therapeutics is a clinical-stage biotechnology company focused on developing treatments for autoimmune and chronic inflammatory diseases [3] - The lead product candidate is rezpegaldesleukin (REZPEG or NKTR-358), a first-in-class regulatory T cell stimulator currently in two Phase 2b clinical trials for atopic dermatitis and alopecia areata [3] - The pipeline includes a preclinical bivalent TNFR2 antibody, bispecific programs NKTR-0165 and NKTR-0166, and a modified CSF protein NKTR-422 [3] - Nektar is also evaluating NKTR-255, an investigational IL-15 receptor agonist aimed at enhancing the immune system's ability to combat cancer, in several ongoing clinical trials [3] - The company is headquartered in San Francisco, California [3]