Results of the Resolve-AD trial with rezpegaldesleukin were better than expected.Shares of Nektar Therapeutics (NKTR 0.08%), a biopharmaceutical company, shot 90.6% higher in October, according to data from S&P Global Market Intelligence. Investors have been increasingly enthusiastic about recently announced clinical trial results for its lead candidate, rezpegaldesleukin.In a nutshell, it looks like it could become a top-selling treatment for eczema, an itchy autoimmune disorder that affects roughly 10% of ...

Group 1 - Investors in the biotechnology sector have seen significant stock price increases, with Nektar Therapeutics and Mineralys Therapeutics both experiencing over 100% gains in the month leading up to September 19 [1] - Nektar Therapeutics' stock surged 108% from August 18 to September 18, driven by positive investor sentiment regarding its lead candidate, rezpegaldesleukin, an IL-2 pathway agonist [3][4] - In a phase 2b study for moderate to severe eczema, the highest dose of rezpegaldesleukin showed a 30% placebo-adjusted improvement, indicating potential competition with Dupixent, which generated $14.2 billion in sales last year [4][5] Group 2 - In the Rezolve-AD trial, 42% of patients achieved 75% skin clearance with rezpegaldesleukin compared to 17% in the placebo group, and in a longer treatment duration group, 62% achieved the same result [5][6] - Nektar Therapeutics currently has a market cap of $989 million, which is considered low for a company with a potential blockbuster treatment in mid-stage trials, although it has no products on the market [7] - A successful phase 3 trial for rezpegaldesleukin could significantly increase Nektar's stock value, but the company has not yet initiated a phase 3 program [9]

Jefferies analyst Roger Song sets a price target of $99 for NKTR, indicating a potential increase of 68.54%.NKTR's stock price surged over 15% following positive phase 2b study results of rezpegaldesleukin for atopic dermatitis.Rezpegaldesleukin demonstrated significant improvement in eczema area and severity index, with EASI-75 response deepening to 62% and vIGA-AD 0/1 response increasing to 38%.Nektar Therapeutics, traded on the NASDAQ under the symbol NKTR, is a biopharmaceutical company focused on devel ...

Key Points The biotech published a readout from a clinical trial of an investigational treatment for a skin disorder. Rezpegaldesleukin did well in its latest atopic dermatitis study. 10 stocks we like better than Nektar Therapeutics › Clinical-stage biotech Nektar Therapeutics (NASDAQ: NKTR) had some encouraging news to report from the lab about one of its investigational medicines on Thursday. As often happens in such circumstances, investors flocked to the stock, and it closed the trading sessio ...

Core Insights - Nektar Therapeutics Inc. presented new data from its REZOLVE-AD Phase 2b study of rezpegaldesleukin, showing significant efficacy in treating moderate to severe atopic dermatitis [1][2] Study Results - The primary endpoint was met with a statistically significant improvement in the Eczema Area and Severity Index (EASI) at week 16 compared to placebo [2] - Key secondary endpoints, including EASI-75, EASI-90, Itch Numerical Rating Scale (NRS), vIGA-AD, and Body Surface Area (BSA), also showed significant disease reduction [2] - The study randomized 393 patients to receive different dosing regimens of rezpegaldesleukin or placebo, with the mean improvement on EASI score being 61% for the high dose (24 µg/kg every two weeks), 58% for the middle dose (18 µg/kg every two weeks), and 53% for the low dose (24 µg/kg every four weeks), compared to 31% in the placebo group [3] Crossover Data - Interim data showed that 42 placebo patients crossed over to the treatment arm, with 21 patients reaching 24 weeks of treatment with high-dose rezpegaldesleukin [4] - The mean percent reduction in EASI at crossover week 16 was 68%, and at crossover week 24, it was 75% [4] - EASI-75 responses at crossover week 16 and week 24 were 50% and 62%, respectively [4] Patient Response Rates - The percentage of patients achieving a vIGA-AD 0/1 response was 28% at week 16 and 38% at week 24 [5] - Response rates for EASI-75 were 42% for the 24 µg/kg every two weeks cohort, 46% for the 18 µg/kg every two weeks cohort, and 34% for the 24 µg/kg once-monthly cohort, compared to 17% in the placebo cohort [6] Market Reaction - Following the announcement, Nektar stock increased by 11.34%, reaching $56.86 [5]

Accessibility StatementSkip Navigation Highlights of the REZOLVE-AD Phase 2b Study: Week 16 Efficacy | 24 µg/kg q2w | 18 µg/kg q2w | 24 µg/kg q4w | Placebo | | | | --- | --- | --- | --- | --- | --- | | (high dose) | (middle dose) | (low dose) | | | | | Primary Endpoint | N=104 | N=106 | N=110 | N=73 | | | Mean improvement inEASI score frombaseline | 61% | 58% | 53% | 31Â | % | | | p<0.001 | p<0.001 | p<0.001 | | | | Key SecondaryEndpoints | N=73 | N=104 | N=106 | N=110 | | | | 42% | 46% | 34% | | | | EASI-7 ...

Nektar Therapeutics Conference Call Summary Company Overview - Nektar Therapeutics focuses on immune science, particularly regulatory T cell (Treg) biology, to treat autoimmune and chronic inflammatory diseases [2][4] Key Points on Tregs and Atopic Dermatitis - Tregs are essential for regulating inflammatory processes and maintaining peripheral tolerance, which is crucial in preventing autoimmune diseases [3] - The company has published significant findings from a Phase 1b study demonstrating that ResPEG, a Treg inducer, showed dose-dependent efficacy in treating atopic dermatitis, with disease control maintained for six months post-treatment despite a short drug half-life of 10 days [4][5] ResPEG Development and Differentiation - ResPEG (formerly NKTR-358) was developed using an in vivo phenotypic screening approach, distinguishing it from other IL-2 therapies by achieving durable signaling without oversignaling Tregs [6][7] - Over 1,000 patients have been exposed to ResPEG across multiple studies, showing consistent pharmacodynamics and efficacy, particularly in skin diseases [8] Phase 2b Study Design and Results - The Phase 2b study enrolled 393 patients with moderate to severe atopic dermatitis, randomized into different dosing regimens of ResPEG versus placebo over a 16-week period [10][11] - Primary endpoint was the EASI percent change from baseline at week 16, with secondary endpoints including responder rates and itch response [12] Competitive Landscape - Current approved treatments for atopic dermatitis include IL-4 and IL-13 inhibitors like Dupixent, Adbry, and Lebrikizumab, which have set a standard of care but require continuous dosing [13][14] - ResPEG offers a potential differentiation by providing prolonged disease control without the rebound effects seen with current therapies [15] Safety Profile and Injection Site Reactions - Injection site reactions (ISRs) were reported in 70% of patients, but most were mild to moderate and self-limiting, with only 0.6% leading to treatment discontinuation [18][19] - The company is developing an autoinjector to standardize administration and mitigate ISRs [21] Upcoming Data and Future Catalysts - Additional data on patient-reported outcomes and extended treatment effects will be presented at the American Academy of Dermatology conference [22][25] - Long-term maintenance data from the Phase 2b study is expected in early 2026, with ongoing studies exploring the efficacy of ResPEG in alopecia [26][32] Alopecia Indication - Nektar is also exploring ResPEG for alopecia, focusing on Tregs' role in hair growth and homeostasis [33] - The company aims to establish benchmarks against existing JAK inhibitors, which have shown high efficacy but require continuous dosing [34][35] Conclusion - Nektar Therapeutics is positioned to offer innovative treatments for autoimmune diseases, particularly through its unique approach with ResPEG, which may provide significant advantages over existing therapies in terms of efficacy and safety profiles [4][15][35]

Nektar Therapeutics (NASDAQ:NKTR) has a ROIC of -63.50% compared to its WACC of 11.16%, indicating inefficiencies in capital utilization.Comparatively, Alkermes plc (NASDAQ:ALKS) demonstrates strong financial performance with a ROIC of 18.03% and a WACC of 6.18%.Sangamo Therapeutics, Inc. (NASDAQ:SGMO) also faces challenges similar to Nektar, with a ROIC of -125.56% against a WACC of 8.02%.Nektar Therapeutics (NASDAQ:NKTR) is a biopharmaceutical company that focuses on developing innovative medicines in are ...

Nektar Therapeutics (NasdaqCM:NKTR) FY Conference September 10, 2025 10:30 AM ET Speaker0Get started. Good morning, everyone. Thanks for joining us today. My name is Arthur He, a senior biotech analyst at the HC Wainwright. Thanks for joining us to have a conversation with doctor Jonathan Zalevsky, chief r and d officer.A little bit about Nektar. Nektar is a global biopharmaceutical company focused on developing novel therapies that selectively moderate the immune system to treat autoimmune disorder by leve ...

Accessibility StatementSkip Navigation SAN FRANCISCO. Sept. 9. 2025 /PRNewswire/ -- Nektar Therapeutics (Nasdag: NKTR) announced todav that it will present results from the ongoing REZOLVE-AD Phase 2b study at the 2025 European Academy of Dermatology and Venereology (EADV) Congress being held in Paris, France from September 17-20, 2025. The presentation will include Phase 2b results on the primary and secondary endpoints from the 16-week induction phase of the REZOLVE-AD study, including multiple patient-re ...