Core Insights - Premarket trading is showing notable activity with significant price movements indicating potential trading opportunities before the market opens [1] Premarket Gainers - Cemtrex, Inc. (CETX) has increased by 284% to $11.79 - Treasure Global Inc. (TGL) has risen by 135% to $59.83 - Top Wealth Group Holding Limited (TWG) is up 95% at $11.73 - Fulcrum Therapeutics, Inc. (FULC) has gained 49% to $13.29 - MetaVia Inc. (MTVA) is up 33% at $10.90 - Kymera Therapeutics, Inc. (KYMR) has increased by 31% to $87.58 - Confluent, Inc. (CFLT) is up 27% at $29.40 - Immix Biopharma, Inc. (IMMX) has risen by 23% to $6.85 - Nurix Therapeutics, Inc. (NRIX) is up 18% at $21.46 - SU Group Holdings Limited (SUGP) has increased by 15% to $6.44 [3] Premarket Losers - SMX (Security Matters) Public Limited Company (SMX) has decreased by 27% to $242.01 - Meihua International Medical Technologies Co., Ltd. (MHUA) is down 27% at $10.20 - Polyrizon Ltd. (PLRZ) has declined by 16% to $10.90 - Fly-E Group, Inc. (FLYE) is down 16% at $6.90 - Sensei Biotherapeutics, Inc. (SNSE) has decreased by 14% to $8.29 - Kentucky First Federal Bancorp (KFFB) is down 10% at $4.00 - Arteris, Inc. (AIP) has declined by 7% to $16.27 - Fusion Fuel Green PLC (HTOO) is down 6% at $3.89 - Kamada Ltd. (KMDA) has decreased by 5% to $6.69 - iOThree Limited (IOTR) is down 5% at $3.11 [4]

Core Insights - Nurix Therapeutics presented new clinical data for bexobrutideg, a BTK degrader, showing an objective response rate (ORR) of 75.0% in heavily pre-treated Waldenström macroglobulinemia patients [1][4] - The drug demonstrated durable responses and was well tolerated, with no dose-limiting toxicities reported [2][3] - The company aims to position bexobrutideg as a best-in-class therapeutic option for various hematological malignancies [2] Clinical Data Summary - The Phase 1 trial included 31 patients with a median age of 71 years and a median of 3 prior lines of therapy [2][4] - Among the patients, 77.4% had MYD88 mutations and 19.4% had CXCR4 mutations, with 100% having prior BTK inhibitor treatment [2] - The ORR included very good partial responses (VGPR) in 10.7% of patients, partial responses (PR) in 50.0%, and minor responses (MR) in 14.3% [4] Safety and Tolerability - Bexobrutideg was well tolerated, with common adverse events being low grade, including neutropenia (29.0%) and diarrhea (25.8%) [3] - No new onset atrial fibrillation was observed, and only two treatment-emergent adverse events led to drug discontinuation [3] Future Development - The company plans to expand the development of bexobrutideg into chronic lymphocytic leukemia (CLL) and other non-Hodgkin lymphoma (NHL) indications [2][8] - Nurix is also advancing multiple other drug candidates in its pipeline, focusing on targeted protein degradation [9]

Summary of Nurix Therapeutics FY Conference Call Company Overview - **Company**: Nurix Therapeutics (NasdaqGM:NRIX) - **Focus**: Development of targeted protein degrader drugs, primarily in oncology and autoimmune diseases [3][4] Pipeline and Key Products - **Lead Program**: Bexobrutadeg (formerly NX5948), a targeted protein degrader of BTK, currently in pivotal studies for Chronic Lymphocytic Leukemia (CLL) [3][4] - **Upcoming Trials**: Phase 3 randomized confirmatory trial for Bexobrutadeg planned to start in the first half of 2026 [3][4] - **Safety Profile**: Over 200 patients treated, showing a favorable safety profile and potential applications in autoimmune diseases [4] - **Additional Products**: - STAT6 degrader (NX3911) developed in collaboration with Sanofi, currently in IND enabling studies [5][26] - IRAK4 degrader in collaboration with Gilead, currently in phase one [5][31] Competitive Advantages of Bexobrutadeg - **Mechanism**: Unlike traditional BTK inhibitors, Bexobrutadeg completely removes the BTK protein, addressing both kinase and scaffolding functions [6][7] - **Efficacy**: Higher efficacy and ability to address resistance mutations compared to existing BTK inhibitors [7][10] - **Selectivity**: Bexobrutadeg shows a 64-fold selectivity against TEC, reducing potential cardiovascular side effects [11][12] Upcoming Data Presentations - **ASH Meeting**: Presentations on CLL and Waldenström's macroglobulinemia, focusing on duration of effect and progression-free survival [13][14] - **Subgroup Analyses**: First-time presentation of subgroup analyses based on mutations and prior treatments [15][16] Market Opportunity - **CLL Market Size**: Estimated at $9.5 billion annually for BTK targeted agents, with significant opportunities in second-line and third-line treatments [21][22] - **Patient Numbers**: Approximately 10,000 new patient prescriptions annually in the second line and 6,000 in the third line in the U.S. [21] Future Directions - **Combination Trials**: Plans to explore combination therapies with BCL-2 inhibitors and anti-CD20 agents in both second-line and front-line settings [22][23] - **Autoimmune Indications**: Investigating potential applications in multiple sclerosis (MS) and other inflammatory disorders [23][24] Collaborations and Partnerships - **Sanofi**: Collaboration on STAT6 degrader, with potential IND filing in 2026 [26][27] - **Gilead**: Partnership on IRAK4 program, with phase 1 data expected in 2026 [31] Conclusion - Nurix Therapeutics is positioned to leverage its innovative degrader platform to address significant unmet needs in oncology and autoimmune diseases, with a robust pipeline and strategic collaborations enhancing its market potential [3][4][5]

Core Insights - Nurix Therapeutics, Inc. is set to host a live webcast on December 8, 2025, to present new clinical data from its ongoing Phase 1a/1b trial of bexobrutideg, a BTK degrader program, along with a corporate update [1][2] Company Overview - Nurix Therapeutics is a clinical-stage biopharmaceutical company focused on developing targeted protein degradation medicines for oncology and autoimmune diseases [5] - The company’s pipeline includes BTK degraders and CBL-B inhibitors, with ongoing collaborations with major pharmaceutical companies like Sanofi and Gilead [5] Clinical Trial Information - Bexobrutideg (NX-5948) is currently being evaluated in the DAYBreak CLL-201 clinical trial, a pivotal Phase 2 study for patients with relapsed or refractory chronic lymphocytic leukemia [4] - The NX-5948-301 Phase 1a/1b trial is also ongoing for patients with relapsed or refractory B cell malignancies [4] Webcast Details - The webcast will feature presentations from key figures including Dr. Alvaro Alencar and Dr. Arthur T. Sands, discussing clinical data and Nurix's development strategy [2][3]

Core Insights - Nurix Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on targeted protein degradation medicines for oncology and autoimmune diseases [3] Company Overview - Nurix's pipeline includes degraders of Bruton's tyrosine kinase (BTK) and inhibitors of Casitas B-lineage lymphoma proto-oncogene B (CBL-B) [3] - The company is advancing multiple potentially first-in-class or best-in-class degraders and degrader antibody conjugates (DACs) in its preclinical pipeline [3] - Nurix has partnered with Gilead, Sanofi, and Pfizer for drug discovery, retaining options for co-development and profit sharing in the U.S. [3] - The company utilizes an AI-integrated discovery engine and has expertise in ligase to enhance its clinical advancements [3] Upcoming Events - Arthur T. Sands, M.D., Ph.D., and Hans van Houte will participate in a fireside chat at the Piper Sandler 37th Annual Healthcare Conference on December 3, 2025 [1] - The event will be webcast live and archived for 30 days [2]

Summary of Nurix Therapeutics Conference Call Company Overview - **Company**: Nurix Therapeutics (NasdaqGM:NRIX) - **Event**: Jefferies London Healthcare Conference 2025 - **Date**: November 19, 2025 Key Points Industry and Product Focus - Nurix Therapeutics is focused on developing therapies for Chronic Lymphocytic Leukemia (CLL) and other indications using their BTK degrader platform, specifically Bexobrutideg and NX-5948 [3][4][5] Upcoming Events and Data Releases - The company will present data at the upcoming ASH conference, including follow-up data from Phase 1A and Phase 1B trials for Bexobrutideg and NX-5948 [3][4] - Key metrics to be reported include duration of therapy and duration of response, with patients having been on therapy for over two years [3][4] Pivotal Trial Design - The pivotal trial for Bexobrutideg will focus on a triple-exposed patient population in CLL, with a selected dose of 600 mg once daily based on Phase 1B data [4][6] - The trial aims for accelerated approval, allowing early market access, while full approval will follow a randomized control study [10][11] Competitive Landscape - The company anticipates competition from pirtobrutinib, a non-covalent BTK inhibitor from Eli Lilly, which is expected to gain full approval [8][10] - Nurix is positioning Bexobrutideg as a potential standard of care in the U.S. market for CLL [10] Combination Therapies - Nurix is planning combination studies with Bexobrutideg and other therapies, including venetoclax and anti-CD20 antibodies [22][23] - The company is also exploring the potential of combining with T-cell engagers [23] Autoimmune Indications - The company is developing Bexobrutideg for autoimmune diseases, leveraging its ability to degrade BTK, which may provide advantages over traditional inhibitors [26][27] - A new formulation for Bexobrutideg is in development, with plans for IND submission in 2026 [27] Partnerships and Pipeline - Nurix has partnerships with Gilead for an IRAK4 degrader and with Sanofi for a STAT6 degrader, both of which are in various stages of development [35][36] - The IRAK4 program is in Phase 1, while the STAT6 program is in IND enabling studies [35][36] Financial Position - Nurix recently raised $250 million, bringing total cash reserves to over $650 million, providing a strong financial runway through early 2028 [41][42] Future Considerations - The company is preparing for multiple decisions regarding its partnerships and potential opt-ins based on upcoming clinical data [38][41] Conclusion - Nurix Therapeutics is strategically positioned in the biotech space with a focus on innovative therapies for CLL and autoimmune diseases, backed by a strong financial position and promising clinical data on the horizon [41][42]

Summary of Nurix Therapeutics Conference Call Company Overview - **Company**: Nurix Therapeutics (NasdaqGM:NRIX) - **Focus**: Targeted protein degradation, primarily in oncology and inflammation Key Points Industry and Product Development - Nurix is pioneering targeted protein degradation as a new therapeutic modality, starting with Chronic Lymphocytic Leukemia (CLL) [2][3] - The lead product, Bexobrutideg (Bexdeg), targets BTK, a validated drug target, and has shown an 80% response rate in CLL patients who have undergone four prior lines of therapy [2][3] Clinical Trials and Efficacy - Initiated pivotal trials for Bexdeg in CLL, with a focus on a triple-exposed patient population (patients treated with covalent BTK inhibitors, BCL-2 inhibitors, and non-covalent BTK inhibitors) [9][10] - The 600 mg dose of Bexdeg is expected to provide better coverage against resistance mutations and improve overall efficacy and progression-free survival [6][39] - The confirmatory phase III trial is designed to assess superiority over standard care, with a focus on global enrollment strategies [30][29] Regulatory Considerations - Discussions with the FDA regarding the appropriateness of the triple-exposed patient population for accelerated approval are ongoing, with a target follow-up duration of about one year [12][17] - The accelerated approval paradigm is under scrutiny, with Nurix confident in the unmet medical need for the triple-exposed population [13][14] Upcoming Data and Events - The upcoming ASH conference is expected to provide critical data on dose expansion and efficacy, particularly regarding duration of response and justification for the 600 mg dose [31][32] - The company aims to present data that will inform the design of the phase III trial and its relevance to the future CLL marketplace [29][32] Competitive Landscape - Bexdeg is positioned as a highly selective drug compared to competitors, with proteomics data indicating minimal off-target effects [36][38] - The company is also exploring applications in inflammation and immunology, with ongoing studies for IRAK4 and STAT6 degraders [41][52] Financial Position - Nurix has over $650 million in cash, providing a runway through the end of 2027 into 2028, which supports the launch of pivotal programs and advancement of the pipeline [55][56] Conclusion - Nurix Therapeutics is at the forefront of targeted protein degradation, with promising clinical data and a strong financial position to support its innovative therapies in oncology and inflammation. The upcoming ASH conference will be pivotal for investor insights and future developments.

Core Insights - Nurix Therapeutics, Inc. has appointed Dr. Roger Dansey to its board of directors, enhancing the company's expertise in research, drug development, and commercialization [1][2] - Dr. Dansey brings over two decades of leadership experience in hematology and oncology, having held significant roles at Pfizer and Seagen [1][2] - Nurix is focused on targeted protein degradation medicines, aiming to innovate treatment options for cancer and autoimmune diseases [3] Company Overview - Nurix Therapeutics is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of targeted protein degradation medicines [3] - The company's pipeline includes degraders of Bruton's tyrosine kinase (BTK) and inhibitors of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), with a focus on improving treatment for various cancers and autoimmune diseases [3] - Nurix's partnered drug discovery pipeline features collaborations with Gilead, Sanofi, and Pfizer, retaining options for co-development and profit sharing in the U.S. [3] Leadership and Expertise - Dr. Dansey's previous roles include Chief Development Officer and Chief Oncology Officer at Pfizer Oncology, and Chief Medical Officer at Seagen, where he contributed to the development of breakthrough cancer therapies [2] - His experience includes leadership positions at Merck, Gilead, and Amgen, where he was involved in the registration efforts for Keytruda and the development of Xgeva [2] - Dr. Dansey's appointment is expected to guide Nurix in accelerating pivotal trials for its lead asset, bexobrutideg, in chronic lymphocytic leukemia [2]

Core Insights - Nurix Therapeutics, Inc. presented new translational data from its ongoing Phase 1 study of NX-1607, a first-in-class oral inhibitor of CBL-B, at the SITC 2025 Annual Meeting, highlighting its potential in treating advanced solid tumors [1][4] Group 1: Clinical Data and Findings - The new data from the Phase 1a clinical trial showed that NX-1607 resulted in dose-dependent pharmacologic activity, leading to increased peripheral T cell activation and proliferation, particularly in patients with stable disease [2][7] - A case study of a patient with metastatic castration-resistant prostate cancer (mCRPC) indicated that treatment with NX-1607 was associated with an expansion of activated peripheral memory T cell subsets and enhanced immune activation gene signatures [3][7] - The findings suggest that NX-1607 induces peripheral immune activation linked to remodeling of the tumor microenvironment, which may contribute to local tumor control [3][7] Group 2: Mechanism and Rationale - CBL-B inhibition is supported as a novel immune-oncology therapy, with NX-1607 showing signs of immune activation and disease control in heavily pretreated patients [4][6] - The treatment demonstrated dose-dependent pharmacokinetics and pharmacodynamic modulation, confirming target engagement and inhibition of CBL-B-mediated signaling [7] - Transcriptomic analyses revealed dose-dependent enrichment of immune signaling pathways, further supporting the mechanistic link between NX-1607 exposure and immune activation [7] Group 3: Company Overview - Nurix Therapeutics is focused on developing targeted protein degradation medicines for cancer and autoimmune diseases, with a pipeline that includes inhibitors of CBL-B and Bruton's tyrosine kinase [8] - The company is advancing multiple potentially first-in-class or best-in-class therapies, leveraging a fully AI-integrated discovery engine to enhance drug development [8]

Core Insights - Nurix Therapeutics, Inc. announced updated clinical data from the NX-5948-301 Phase 1a/1b clinical trial will be presented at the 67th American Society of Hematology Annual Meeting, focusing on treatments for chronic lymphocytic leukemia (CLL) and Waldenström macroglobulinemia [1][2] Clinical Presentations - An oral presentation titled "Bexobrutideg (NX-5948), a Novel Bruton's Tyrosine Kinase (BTK) Degrader, Demonstrates Rapid and Durable Clinical Responses in Relapsed / Refractory Chronic Lymphocytic Leukemia (CLL)" will take place on December 6, 2025, featuring new findings [3] - A poster presentation will showcase updated results for Waldenström macroglobulinemia, highlighting the clinical activity and safety of Bexobrutideg [4] Mechanistic Insights - Nurix and collaborators will present new insights into resistance mechanisms to BTK-targeted therapies, expanding the understanding of BTK biology [2] Product Information - Bexobrutideg (NX-5948) is an investigational small molecule degrader of BTK, currently evaluated in pivotal and ongoing clinical trials for relapsed or refractory CLL and B cell malignancies [5] Company Overview - Nurix Therapeutics focuses on the discovery and development of targeted protein degradation medicines, aiming to improve treatment options for cancer and autoimmune diseases [6][7]