Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-34899 _____________________________________________________________________________________________ Pacific Biosciences of California, Inc. (Exact name of registrant as specified in its charter) ________________________________________________________________________ ...

PacBio Announces Second Quarter 2025 Financial Results MENLO PARK, Calif., August 07, 2025 (GLOBE NEWSWIRE) – PacBio (NASDAQ: PACB) today announced financial results for the quarter ended June 30, 2025. Second quarter results: | | Q2 2025 | Q2 2024 | | --- | --- | --- | | Revenue | $39.8 million | $36.0 million | | Instrument revenue | $14.2 million | $14.7 million | | Consumable revenue | $18.9 million | $17.0 million | | Service and other revenue | $6.7 million | $4.3 million | | TM Revio systems | 15 | 2 ...

Core Insights - PacBio reported a revenue increase in Q2 2025, achieving $39.8 million compared to $36.0 million in Q2 2024, marking a year-over-year growth [1] - The company has successfully reduced operating expenses and cash burn while maintaining revenue growth [6] Financial Performance - Instrument revenue for Q2 2025 was $14.2 million, slightly down from $14.7 million in Q2 2024 [1] - Consumable revenue increased to $18.9 million from $17.0 million year-over-year [1] - Service and other revenue rose to $6.7 million from $4.3 million in the same period last year [1] - GAAP gross profit for Q2 2025 was $14.7 million, up from $5.9 million in Q2 2024, with a non-GAAP gross profit of $15.2 million compared to $13.2 million [2] - Non-GAAP gross margin improved to 38% in Q2 2025 from 37% in Q2 2024 [2] Operating Expenses and Losses - GAAP operating expenses decreased to $59.5 million in Q2 2025 from $181.8 million in Q2 2024 [3] - Non-GAAP operating expenses also fell to $58.1 million from $71.0 million year-over-year [3] - GAAP net loss for Q2 2025 was $41.9 million, significantly reduced from $173.3 million in Q2 2024 [4] - Non-GAAP net loss for the same period was $40.0 million, down from $55.2 million [4] - GAAP net loss per share improved to $0.14 from $0.64 year-over-year [4] Product and Market Developments - The company sold 15 Revio™ systems in Q2 2025, down from 24 in Q2 2024, while it sold 38 Vega™ systems, which were not sold in the previous year [1] - Annualized Revio pull-through per system was approximately $219,000, down from $251,000 [1] - PacBio has expanded its distribution in China through a new agreement with Haorui Gene, enhancing access to clinical lab networks [6] - The company contributed to the 1000 Genomes Long Read Project, focusing on isoform-level transcriptome sequencing [6] Cash and Investments - As of June 30, 2025, PacBio had cash, cash equivalents, and investments totaling $314.7 million, down from $509.8 million a year earlier [1]

Core Insights - PacBio has developed a comprehensive genomic variant dataset called the Platinum Pedigree, which significantly enhances variant classification using AI tools, particularly Google's DeepVariant, achieving a 34% reduction in erroneous variant calls [1][5][6] Group 1: Dataset Development - The Platinum Pedigree dataset is the most extensive family-based variant dataset, characterizing both simple and complex genetic variations [1][2] - It was created through deep sequencing of a 28-member multi-generational family, cataloging over 37 Mb of genetic variation, including single nucleotide and large structural variants [3][4] - The dataset includes the first large pedigree-validated tandem repeat and structural variant truth sets, extending benchmark regions to 2.77 Gb [4] Group 2: Impact on AI and Genomics - The improved benchmarks allow for better evaluation of variant calling pipelines and accelerate the development of methods that address complex genomic regions important for human health [5][6] - The Platinum Pedigree benchmark is already being utilized by scientists to develop new sequence analysis tools and validate clinical sequencing workflows [6] Group 3: Publication and Collaboration - The study detailing the Platinum Pedigree was published in Nature Methods on August 4, 2025, and involved collaboration between PacBio, the University of Washington, and the University of Utah, with support from NIH and Howard Hughes Medical Institute [8]

Pacific Biosciences of California (PACB) closed at $1.54 in the latest trading session, marking a -6.1% move from the prior day. This change lagged the S&P 500's daily loss of 0.3%. Elsewhere, the Dow saw a downswing of 0.46%, while the tech-heavy Nasdaq depreciated by 0.38%. Heading into today, shares of the maker of genetic analysis technology had gained 32.26% over the past month, outpacing the Medical sector's gain of 0.76% and the S&P 500's gain of 3.64%.Investors will be eagerly watching for the perfo ...

Core Insights - Athena Diagnostics, a subsidiary of Quest Diagnostics, has launched a new laboratory test service aimed at identifying genetic causes of ataxia, a group of progressive neurological disorders affecting movement and coordination [1][2]. Company Overview - Athena Diagnostics specializes in diagnostic testing for neurological diseases and offers innovative tests for conditions such as Alzheimer's disease and muscular dystrophy [7]. - Quest Diagnostics is a leading provider of diagnostic information services and has collaborated with PacBio to develop the new ataxia test using advanced sequencing technology [1][3]. Technology and Methodology - The new test utilizes PacBio's PureTarget sequencing method, which is designed to identify long repeating DNA sequences that conventional sequencing technologies may miss [2][3]. - The test will confirm initial screening results obtained through polymerase chain reaction (PCR) testing, enhancing the quality of confirmatory testing for ataxia [2][5]. Clinical Relevance - A study indicated that the PureTarget gene panel could identify specific repeating gene patterns associated with Spinocerebellar ataxia type 10, potentially guiding care decisions based on the age of disease onset [4]. - The prevalence of ataxia in children is reported to be 26 per 100,000, with 10 per 100,000 cases attributed to genetic factors [6]. Future Developments - Athena Diagnostics is exploring the development of additional tests based on PacBio technology to enhance carrier screening capabilities [3].

Core Insights - The study published the first Arab human pangenome, significantly advancing global genomic equity and highlighting the importance of population-specific genomic data [1][3] - The research identified millions of new variants and over 111 million base pairs of previously unsequenced DNA, enhancing the understanding of genetic diversity in Arab populations [2][4] Company Contributions - PacBio's HiFi long-read sequencing technology was instrumental in assembling high-resolution genomes from diverse Arab populations, showcasing the company's leadership in genomic research [1][3][7] - The Arab pangenome, or UAE Pangenome Reference (UPR), improves mapping rates and variant recall, providing a valuable tool for precision medicine in underrepresented populations [5][6] Implications for Research - The findings from the study have significant implications for understanding disease risk, diagnosing rare conditions, and improving representation in global health research [4][6] - The UPR is freely available to support ongoing research into genetic disorders and population health, potentially increasing variant detection accuracy in Arab genomes [6]

Core Insights - PacBio has joined the 1000 Genomes Long Read Sequencing Project to contribute long-read transcriptome data, enhancing the understanding of human genomics [1][2][3] - The collaboration aims to provide new transcript-level insights from approximately 1,000 samples, supporting accurate gene expression interpretation and regulatory element analysis [2][3] - The project emphasizes transparency and open data, with all sequencing data and analysis pipelines to be publicly available [4][5] Company Contributions - PacBio will utilize its Kinnex RNA kits and Revio sequencing platform to generate full-length isoform sequencing data, with each sample expected to yield around 10 million full-length transcript reads [3] - The collaboration involves key laboratories, including the University of Washington and Johns Hopkins University, to deliver a high-quality RNA resource and scalable bioinformatics pipelines [3][4] Industry Impact - The addition of isoform sequencing to the 1000 Genomes Project is expected to enrich the foundational genomic resource, aiding in diverse applications from basic biology to rare disease diagnostics [3] - The initiative aims to advance equity, access, and innovation in human genetics research, contributing to the fast-growing field of long-read transcriptomics [5]

Core Viewpoint - PacBio is set to hold its quarterly conference call to discuss its second quarter 2025 financial results on August 7, 2025, at 5:00 pm Eastern Time [1][2]. Company Overview - PacBio (NASDAQ: PACB) is a leading life science technology company that specializes in designing, developing, and manufacturing advanced sequencing solutions aimed at resolving genetically complex problems for scientists and clinical researchers [2]. - The company's product offerings include HiFi long-read sequencing technologies that cater to a wide range of research applications, including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications [2]. Conference Call Details - The conference call will be accessible via webcast on PacBio's investor website [1]. - Participants can join the call by dialing in, with a toll-free number for domestic calls and an international number provided [2].

Company Performance - Pacific Biosciences of California (PACB) closed at $1.50, with a daily increase of +1.35%, outperforming the S&P 500's gain of 0.28% [1] - The stock has increased by 27.59% over the past month, leading the Medical sector's gain of 0.24% and the S&P 500's gain of 4.37% [1] Earnings Expectations - Analysts expect Pacific Biosciences to report earnings of -$0.18 per share, reflecting a year-over-year growth of 10% [2] - The revenue forecast for the upcoming quarter is $36.46 million, indicating a growth of 1.26% compared to the same quarter last year [2] Full Year Projections - For the full year, earnings are projected at -$0.64 per share and revenue at $155.12 million, showing changes of +22.89% and +0.72% respectively from the previous year [3] Analyst Sentiment - Recent adjustments to analyst estimates indicate positive sentiment towards Pacific Biosciences' business operations and profit generation capabilities [4] - The Zacks Rank system, which assesses stock performance based on estimate changes, currently ranks Pacific Biosciences as 1 (Strong Buy) [6] Industry Context - The Medical - Instruments industry, which includes Pacific Biosciences, has a Zacks Industry Rank of 173, placing it in the bottom 30% of over 250 industries [7] - Research indicates that the top 50% rated industries outperform the bottom half by a factor of 2 to 1 [7]