UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) or (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☐ SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 19 ...

Exhibit 99.1 Pyxis Tankers Announces Financial Results for the Three Months and Year Ended December 31, 2021 Maroussi, Greece, March 18, 2022 – Pyxis Tankers Inc. (NASDAQ Cap Mkts: PXS), (the "Company" or "Pyxis Tankers"), a growth- oriented pure play product tanker company, today announced unaudited results for the three months and year ended December 31, 2021. Summary For the three months ended December 31, 2021, our Revenues, net were $8.1 million. For the same period, our time charter equivalent ("TCE") ...

Pyxis Tankers Inc. (NASDAQ:PXS) Q4 2021 Earnings Conference Call March 18, 2022 4:30 PM ET Company Participants Eddie Valentis - Chairman and Chief Executive Officer Henry Williams - Chief Financial Officer and Treasurer Operator Good day and welcome to the Pyxis Tankers Conference Call to discuss the Financial Results for the Fourth Quarter 2021. As a reminder, today's call is being recorded. Additionally, a live webcast of today's conference call and an accompanying presentation is available on Pyxis Tank ...

PYXIS COMPANY PRESENTATION January 2022 DISCLAIMER & FORWARD-LOOKING STATEMENTS This presentation contains forward-looking statements and forward-looking information within the meaning of the Private Securities Litigation Reform Act of 1995 applicable securities laws. The words "expected'', "estimated", "scheduled", "could", "should", "anticipated", "long-term", "opportunities", "potential", "continue", "likely", "may", "will", "positioned", "possible", "believe", "expand" and variations of these terms and ...

PYXIS COMPANY PRESENTATION November 2021 DISCLAIMER & FORWARD-LOOKING STATEMENTS This presentation contains forward-looking statements and forward-looking information within the meaning of the Private Securities Litigation Reform Act of 1995 applicable securities laws. The words "expected'', "estimated", "scheduled", "could", "should", "anticipated", "long-term", "opportunities", "potential", "continue", "likely", "may", "will", "positioned", "possible", "believe", "expand" and variations of these terms and ...

Pyxis Tankers Inc. (NASDAQ:PXS) Q3 2021 Results Earnings Conference Call November 15, 2021 4:30 PM ET Company Participants Valentios Valentis - Chairman and Chief Executive Officer Henry Williams - Chief Financial Officer and Treasurer Conference Call Participants Operator Good day and welcome to the Pyxis Tankers Conference Call to discuss the Financial Results for the Third Quarter 2021. As a reminder, today's call is being recorded. Additionally, a live webcast of today's conference call and an accompany ...

Exhibit 99.1 September 30, 2021 TO THE SHAREHOLDERS OF PYXIS TANKERS INC. Enclosed is a Notice of the 2021 Annual Meeting of Shareholders (the "Meeting") of Pyxis Tankers Inc. (the "Company"), which will be held at the Company's offices at 59, K. Karamanli Street, Maroussi 15125, Greece on Thursday, November 11, 2021 at 4:30 p.m., Greek time, the Company's Proxy Statement and certain other related materials. These materials, together with the Company's annual report on Form 20-F, which contains the Company' ...

Pyxis Tankers Inc. (NASDAQ:PXS) Q2 2021 Earnings Conference Call August 9, 2021 8:30 AM ET Company Participants Eddie Valentis - Chairman and CEO Henry Williams - CFO Conference Call Participants Operator Good day and welcome to the Pyxis TankersÂ' Conference Call to discuss the Financial Results for the Second Quarter 2021. As a reminder, today's call is being recorded. Additionally, a live webcast of today's conference call and an accompanying presentation is available on Pyxis TankersÂ' website, which is ...

PYXIS TANKERS Q2 2021 Financial Results August 9, 2021 DISCLAIMER FORWARD-LOOKING STATEMENTS & INFORMATION This presentation contains forward-looking statements and forward-looking information within the meaning of the Private Securities Litigation Reform Act of 1995 applicable securities laws. The words "expected'', "estimated", "scheduled", "could", "should", "anticipated", "long-term", "opportunities", "potential", "continue", "likely", "may", "will", "positioned", "possible", "believe", "expand" and var ...

PYXIS Q1 2021 Financial Results June 2, 2021 DISCLAIMER FORWARD-LOOKING STATEMENTS & INFORMATION This presentation contains forward-looking statements and forward-looking information within the meaning of the Private Securities Litigation Reform Act of 1995 applicable securities laws. The words "expected'', "estimated", "scheduled", "could", "should", "anticipated", "long-term", "opportunities", "potential", "continue", "likely", "may", "will", "positioned", "possible", "believe", "expand" and variations of ...