Quantum-Si Conference Call Summary Company Overview - **Company**: Quantum-Si (NasdaqGM:QSI) - **Industry**: Life Sciences Tools and Diagnostics - **Technology**: Utilizes semiconductor chip technology for single-molecule protein sequencing with products including the Platinum instrument and QSI Cloud software [3][4] Key Points and Arguments Product Portfolio and Technology - **Current Products**: The first-generation technology includes the Platinum and Platinum Pro instruments, which have been in the market for about three years [4] - **Business Model**: Operates on a razor-razor blade model where customers purchase the machine and consumables for sample preparation and sequencing [4] - **Upcoming Product**: The Proteus platform represents a significant architectural change, moving optics from consumables to the machine, allowing for higher sequencing output and lower-cost consumables [5][15] Financial Performance and Strategy - **Recent Earnings**: The company has adapted to NIH headwinds by offering alternative purchasing options for the Platinum machine, resulting in 12 machines sold under this program, with over half going to academia [6] - **Publications**: Five publications have been released this year, indicating a strong pipeline and market development [6] - **Cash Position**: Ended Q3 2025 with over $230 million in cash, providing a runway into Q2 2028, which includes 18 months post-Proteus launch [44][46] Proteus Development and Launch Timeline - **Milestones**: Completed sequencing on over 50 runs of the Proteus prototype, achieving this milestone ahead of schedule [7][8] - **Launch Timeline**: Expected to launch Proteus by the end of 2026 [21][22] - **Early Access Program**: Targeting big centers with core labs for testing and comparison against existing technologies [26][28] Pricing Strategy - **Price Range**: Anticipated pricing for Proteus is between $300,000 and $500,000, reflecting its advanced capabilities compared to the current Platinum device priced at $125,000 [23][24] - **Market Accessibility**: The pricing strategy aims to balance value capture with accessibility to avoid constraining the number of potential users [25] R&D and Technological Advancements - **AI and Binding Kinetics**: The integration of AI tools has accelerated the development of engineered protein recognizers, enhancing the ability to achieve full proteome coverage [30][31] - **Proteome Coverage Goals**: Aiming to demonstrate coverage of all 20 amino acids by 2026, which would enable advanced applications in single amino acid variants and post-translational modifications (PTMs) [33] Commercialization Strategy - **Sales Strategy**: Considering various sales models for Proteus, including trade-ins for existing Platinum users, while leaning towards capital sales [39][40] - **Long-term Focus**: Emphasis on capital efficiency and targeted investments to support the Proteus launch and subsequent commercialization efforts [46][47] Additional Important Insights - **Engineering and Chemistry Hurdles**: Early data from Proteus shows improvements across all metrics compared to the Platinum machine, indicating a de-risked program moving towards commercialization [10][12] - **Controlled Cleavage Technology**: Future versions of Proteus may incorporate controlled cleavage technology to enhance sequencing capabilities [41][43] - **Strategic Opportunities**: Open to exploring strategic opportunities and technologies that align with Quantum-Si's goals, while maintaining focus on the Proteus launch [47]

Core Insights - The presentation aims to provide an overview of the company's advancements in proteomics and the associated challenges in understanding the complexity of the proteome [1] - The focus is on the Proteus program, which represents the majority of the company's R&D investment, highlighting its significance in enhancing performance [1] Group 1: Technology and R&D - The company is investing heavily in the Proteus program, which is central to its current R&D efforts [1] - There are also modest investments in long-term technology development, indicating a balanced approach to immediate and future innovations [1] Group 2: Future Developments - Upcoming discussions will include plans to expand to 20 amino acids, with details on the timeline for achieving this goal [2]

Quantum-Si (NasdaqGM:QSI) 2025 Investor Day November 19, 2025 10:00 AM ET Company ParticipantsTodd Rearick - CTOBrian Reed - Head of ResearchJohn Biacelli - Chief Product OfficerJeff Hawkins - CEOPuneet Souda - Senior Managing Director of Life Science Tools and DiagnosticsConference Call ParticipantsScott Henry - Senior Research AnalystKyle Mikson - Equity Research AnalystSwayampakula Ramakanth - Senior Equity Research AnalystJeff HawkinsAll right, good morning, everybody. Appreciate everyone being here in ...

Financial Data and Key Metrics Changes - Revenue for Q3 2025 was $552,000, impacted by capital sales headwinds in the market [4][16] - Gross profit was $194,000, with a gross margin of 35% [16] - For the nine months ended September 30, 2025, revenue was $2.0 million, and gross profit was $1.0 million, with a gross margin of 52% [16][18] - Total operating expenses for Q3 2025 were $40 million, compared to $28.5 million in Q3 2024 [18] - Adjusted operating expenses for Q3 2025 were $21.4 million, down from $26.0 million in Q3 2024 [18] Business Line Data and Key Metrics Changes - The company launched an expanded set of instrument acquisition options, resulting in 12 new customers implementing the platform [5] - More than half of the new customers are in academic labs, a segment previously difficult to access due to NIH funding challenges [5] Market Data and Key Metrics Changes - The company experienced year-over-year revenue impacts due to capital market headwinds and NIH funding uncertainties [17] - The placements program has allowed access to key academic centers, with over half of placements going into academic labs [34] Company Strategy and Development Direction - The company aims to accelerate commercial adoption, deliver on its innovation roadmap, and preserve financial strength [4] - The Proteus platform is a key focus, with successful sequencing runs completed on prototype systems [9] - The company is exploring partnership opportunities to enhance development activities and expand market participation [8] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about early traction with the placement program despite ongoing capital market challenges [13] - The company anticipates modest improvement in Q4 2025, but not a significant upswing compared to historical trends [40] - There is uncertainty regarding NIH funding due to the government shutdown, but proposals indicate a potential retention of funding levels [41][42] Other Important Information - The company has a strong balance sheet with $230.5 million in cash and investments as of September 30, 2025 [20] - A Form S-3 shelf registration statement for $300 million was filed to support business initiatives [22] - Management and board collectively hold approximately 18% of the total outstanding stock, indicating strong investment in the company's success [24] Q&A Session Summary Question: Updates on the investor day and Proteus sequencer development - The investor day on November 19 will provide updates on Proteus, including early sequencing data and key milestones for 2026 [28][29] Question: Involvement in DARPA's PRESS program - The company is aware of the PRESS program but does not align perfectly with its microsystem strategy [31] Question: Breakdown of placements by market segment - More than half of the placements went into academic labs, with the remainder split between pharma, biotech, and agricultural testing [34] Question: Seasonal trends from Q3 to Q4 - A modest improvement is expected in Q4 2025, but not as significant as in typical years due to various challenges [40] Question: Key hurdles to market launch of Proteus - Key hurdles include scaling from prototypes to fully integrated systems and optimizing the platform for manufacturing [44][46]

For the quarterly period ended September 30, 2025 or UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ________ to _________ Commission File Number: 001-39486 QUANTUM-SI INCORPORATED (Exact name of registrant as specified in its charter) ___________________ ...

Exhibit 99.1 Quantum-Si Reports Third Quarter 2025 Financial Results Announces Successful Sequencing on Prototype Proteus Unit, Development Program Remains On-Track BRANFORD, Conn. -- (BUSINESS WIRE) -- November 5, 2025 -- Quantum-Si Incorporated (Nasdaq: QSI) ("Quantum-Si," "QSI" or the "Company"), a proteomics technology company redefining protein analysis through single- molecule detection, today announced financial results for the third quarter ended September 30, 2025. Press Release Highlights Total op ...

Alternatively, individuals can register here to receive a dial-in number and personalized PIN to participate in the call. An archived webcast of the event will be available for replay following the event. BRANFORD, Conn.--(BUSINESS WIRE)--Quantum-Si Incorporated (Nasdaq: QSI) ("Quantum-Si,†"QSI†or the "Company†), a proteomics technology company redefining protein analysis through single-molecule detection, today announced that it will report financial results for the third quarter 2025 on Wednesday, Nov ...

It might be seeking to raise up to $300 million in new funding in the future.Quantum-Si's (QSI -4.31%) shares weren't quite the picture of health as the trading week came to an end. Investors, concerned about the healthcare technology company potentially making dilutive secondary share issues, traded out of the stock to leave it with a nearly 5% loss on the day. Sitting on the shelfLate Thursday, Quantum-Si filed a shelf registration -- a regulatory document stating that a company aims to raise capital over ...

Group 1: U.S. Stock Market Overview - U.S. stock futures were higher, with Dow futures gaining over 100 points on Monday [1] Group 2: Inventiva ADR Performance - Inventiva reported losses of $(1.84) per share, significantly worse than the analyst consensus estimate of a loss of 41 cents per share [1] - The company reported quarterly sales of $5.050 million, missing the analyst consensus estimate of $5.310 million [1] - Inventiva shares dipped 5.5% to $5.72 in pre-market trading [1] Group 3: Other Stocks in Pre-Market Trading - MoonLake Immunotherapeutics saw a significant decline of 86.3% to $8.50 in pre-market trading [4] - Cellectis SA declined 10.4% to $3.01 in pre-market trading [4] - Quantum-Si Inc fell 10.1% to $1.34 in pre-market trading after filing for a mixed shelf of up to $300 million [4] - Penguin Solutions Inc decreased by 8.4% to $24.00 in pre-market trading [4] - Lithium Americas Corp declined 5.4% to $5.99 in pre-market trading after a 14% drop on Monday [4] - Platinum Analytics Cayman Ltd fell 5.3% to $16.20 in pre-market trading after a 44% increase on Monday [4] - Novo Nordisk A/S decreased by 2.9% to $54.01 in pre-market trading [4] - Lexicon Pharmaceuticals Inc declined 2.9% to $1.36 in pre-market trading, recently announcing an update on submission of additional data to the U.S. FDA regarding Zynquista® in Type 1 Diabetes [4]

Group 1: U.S. Stock Market Overview - U.S. stock futures were higher, with Dow futures gaining over 100 points on Monday [1] Group 2: Inventiva ADR Performance - Inventiva reported a loss of $(1.84) per share, significantly worse than the analyst consensus estimate of a loss of 41 cents per share [1] - The company’s quarterly sales were $5.050 million, missing the analyst consensus estimate of $5.310 million [1] - Inventiva shares fell 5.5% to $5.72 in pre-market trading [1] Group 3: Other Stocks in Pre-Market Trading - MoonLake Immunotherapeutics saw a significant decline of 86.3% to $8.50 in pre-market trading [4] - Cellectis SA declined 10.4% to $3.01 in pre-market trading [4] - Quantum-Si Inc fell 10.1% to $1.34 in pre-market trading after filing for a mixed shelf of up to $300 million [4] - Penguin Solutions Inc dropped 8.4% to $24.00 in pre-market trading [4] - Lithium Americas Corp declined 5.4% to $5.99 in pre-market trading after a 14% dip on Monday [4] - Platinum Analytics Cayman Ltd fell 5.3% to $16.20 in pre-market trading after a 44% jump on Monday [4] - Novo Nordisk A/S decreased by 2.9% to $54.01 in pre-market trading [4] - Lexicon Pharmaceuticals Inc declined 2.9% to $1.36 in pre-market trading, with an update on additional data submission to the U.S. FDA regarding Zynquista® in Type 1 Diabetes [4]