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The company appears to be on track to develop a commercialized product through its drug discovery system.Recursion Pharmaceuticals (RXRX +2.33%) was in the headlines on Monday, and for the right reason. One of the biotech company's investigational drugs did well in a clinical trial, and investors rewarded the company by trading its stock more than 2% higher on the news. A very encouraging trialBefore market open, Recursion divulged that its REC-4881 demonstrated notable efficacy in a phase 1b/2 trial. The d ...

PresentationNajat KhanChief R&D Officer, Chief Commercial Officer and Director Hi, everyone, and welcome. I'm Najat Khan, Recursion's Chief R&D and Chief Commercial Officer and incoming CEO and President. Let's jump right in. Today is an important moment for Recursion, for our teams and most importantly, for the FAP patient community. We are here to share updated safety and efficacy results from our ongoing Phase I/II TUPELO study evaluating REC-4881 in FAP. Before we begin, please note that today's presen ...

Recursion Pharmaceuticals (NasdaqGS:RXRX) Update Summary Company Overview - **Company**: Recursion Pharmaceuticals - **Focus**: Development of REC-4881 for Familial Adenomatous Polyposis (FAP) - **Key Personnel**: Najat Khan (Chief R&D and Commercial Officer, incoming CEO), Dr. Beth Bruckheimer (FAP clinical lead), Dr. David Mauro (Chief Medical Officer) Industry Context - **Disease**: Familial Adenomatous Polyposis (FAP) - **Patient Population**: Over 50,000 patients in the U.S. and EU5 affected by FAP - **Current Treatment Landscape**: No approved pharmacotherapies for FAP; patients undergo frequent surgeries and interventions Core Findings and Insights 1. **Unmet Need**: FAP is a progressive disease with no approved treatments, leading to severe interventions and surgeries, including the Whipple procedure [2][15][18] 2. **Mechanism of Action**: REC-4881 is a selective MEK1/2 inhibitor that targets the underlying biology of FAP by addressing the loss of APC gene function [3][20] 3. **Clinical Study Results**: - Phase 1b/2 TUPELO study shows that 75% of patients experienced a reduction in polyp burden by week 13, with a median reduction of 43% [25][31] - Durable effects observed, with 82% of patients maintaining a response at week 25, showing a median reduction of 53% [27][29][32] 4. **Safety Profile**: Consistent with MEK inhibitor class expectations; primarily grade 1-2 adverse events, with no grade 4-5 events reported [4][25][31] Additional Insights 1. **Real-World Evidence**: The ClinTECH platform analyzed over 1,000 FAP patients, revealing the relentless progression of polyp growth and the need for effective therapies [10][11][17] 2. **Regulatory Engagement**: Plans to engage with the FDA in the first half of 2026 to discuss a potential registrational pathway for REC-4881 [5][33] 3. **Partnerships and Financials**: Over $500 million generated from collaborations, indicating strong partnership momentum [7][8] Future Directions - **Expansion of Patient Population**: Broadening eligibility from patients over 55 to those over 18 years old [5][33] - **Dosing Optimization**: Exploring alternative dosing regimens to enhance the benefit-risk profile of REC-4881 [33] - **Long-term Goals**: Aim to provide a much-needed therapeutic option that can significantly improve the quality of life for FAP patients [15][33] Conclusion - REC-4881 represents a significant advancement in the treatment of FAP, with promising efficacy and safety data, addressing a critical unmet need in a patient population that currently lacks effective pharmacotherapy options [31][33]

Ongoing Phase 1b/2 Trial of the Allosteric MEK1/2 Inhibitor REC-4881 as Monotherapy in Familial Adenomatous Polyposis (FAP): Updated Safety and Efficacy December 8, 2025 Forward Looking Statements This presentation discusses an investigational product whose safety and efficacy have not been established. This document contains information that includes or is based upon "forward-looking statements" within the meaning of the Securities Litigation Reform Act of 1995, including, without limitation, those regardi ...

Core Insights - Recursion Pharma announced that its experimental oral drug has shown effectiveness in reducing abnormal growths in the colon for patients with a rare genetic condition [1] Company Summary - Recursion Pharma utilizes artificial intelligence in the drug discovery process, focusing on identifying new drug candidates [1] - The company is actively engaged in developing treatments for rare diseases, highlighting its commitment to addressing unmet medical needs [1] Industry Summary - The use of artificial intelligence in pharmaceuticals is gaining traction, with companies like Recursion Pharma leading the way in innovative drug discovery methods [1] - The focus on rare genetic conditions reflects a broader trend in the industry towards personalized medicine and targeted therapies [1]

REC-4881 (4 mg QD) achieved rapid clinical activity, with 75% of evaluable patients showing reductions in total polyp burden and a 43% median reduction after 12 weeks of treatment (n=12)After 12 weeks off therapy (week 25 of the study), 82% of evaluable patients (9 of 11) maintained a durable reduction in total polyp burden, with a 53% median reduction observed from baselineNatural history analysis showed that 87% of untreated FAP patients - who resembled the inclusion criteria of TUPELO - had annualized po ...

Recursion Pharmaceuticals, Inc. (NASDAQ:RXRX) is one of the stocks Jim Cramer discussed, along with the tech battleground. Answering a caller’s query about the stock during the lightning round, Cramer said: “I’m telling you, I am myself confounded by it. The stock has been horrendous. We gotta put that right on the table. I’m talking about horrendous, okay? So I do not like to recommend horrendous stocks. It is so low that it comes in under the category of speculative. As long as you’re willing to take th ...

It has been about a month since the last earnings report for Recursion Pharmaceuticals (RXRX) . Shares have added about 6.5% in that time frame, outperforming the S&P 500.But investors have to be wondering, will the recent positive trend continue leading up to its next earnings release, or is Recursion Pharmaceuticals due for a pullback? Before we dive into how investors and analysts have reacted as of late, let's take a quick look at its most recent earnings report in order to get a better handle on the im ...