Core Insights - Recursion Pharmaceuticals (RXRX) and Schrodinger (SDGR) are leading the integration of artificial intelligence in drug discovery, aiming to transform the biotech sector by improving efficiency and reducing costs [1][2][3] Company Overview Recursion Pharmaceuticals (RXRX) - RXRX utilizes its AI-driven platform, Recursion OS, in collaboration with NVIDIA to enhance drug discovery processes [5] - The company has faced setbacks, including the discontinuation of its lead candidate REC-994 and REC-2282 due to unfavorable efficacy results [6][8] - RXRX is focusing on developing candidates like REC-4881 for familial adenomatous polyposis, which has shown a preliminary median 43% reduction in polyp burden [8] - The company ended Q1 2025 with a cash balance of $509 million, expected to sustain operations into mid-2027 [9] - RXRX has collaboration agreements with major pharmaceutical companies, generating $15 million in collaboration revenues in Q1 2025, a slight increase from the previous year [10] Schrodinger (SDGR) - SDGR employs a physics-based computational platform for drug discovery, with its lead candidate SGR-1505 currently in a phase I study for B-cell malignancies [11][13] - The candidate has received FDA's Orphan Drug designation for mantle cell lymphoma [14] - SDGR's second candidate, SGR-2921, is being evaluated for acute myeloid leukemia, with initial results expected in the second half of 2025 [15] - The company generated $59.6 million in total revenues in Q1 2025, a 63% year-over-year increase [17] Financial Performance - RXRX's stock has declined 39.6% year-to-date, while SDGR's stock has increased by 10.9% [25] - RXRX trades at 1.78 times its book value, significantly lower than SDGR's 4.2 times, making RXRX more attractive from a valuation perspective [26][27] - The Zacks Consensus Estimate for RXRX's 2025 revenues implies a 22% year-over-year improvement, while SDGR's estimate suggests a 21% improvement but a widening loss per share [18][21] Market Position and Competitive Landscape - Both companies face competition from other biotech firms and tech-driven drug discovery companies, which may challenge their market differentiation [31] - Despite the competitive landscape, both RXRX and SDGR have the potential to revolutionize drug discovery by delivering cost-effective therapies [32] - RXRX is viewed as a better investment opportunity due to its innovative pipeline, collaboration agreements, and favorable valuation compared to SDGR [34]

Core Viewpoint - Recursion Pharmaceuticals (RXRX) has experienced a significant stock decline of 21.6% in May due to weaker-than-expected Q1 2025 results and the discontinuation of key drug candidates [1][2][15] Financial Performance - RXRX reported first-quarter 2025 results where both earnings and revenues missed estimates, leading to a year-to-date stock decline of 36.2%, compared to the industry’s 3.8% decline [1][4] - The stock is currently trading below its 50-day and 200-day moving averages, indicating underperformance in the sector and the S&P 500 [4] Pipeline Developments - The company has discontinued the development of its lead candidates, REC-994 and REC-2282, due to unfavorable efficacy results, and also halted the mid-stage study on REC-3964 [2][3][15] - RXRX is focusing on other candidates, such as REC-4881, which has shown a preliminary median 43% reduction in polyp burden in a phase Ib/II study, with additional data expected in H2 2025 [11] - Other candidates in early-stage development include REC-1245 for solid tumors and REC-617 for advanced solid tumors, with cash reserves of $509 million expected to sustain operations into mid-2027 [12] Strategic Collaborations - RXRX has ongoing collaborations with major pharmaceutical companies like Roche, Bayer, and Sanofi, which could enhance its pipeline and revenue potential [13] - The company recently received $7 million in collaboration revenues from Sanofi following a significant discovery milestone [13] Competitive Landscape - RXRX faces intense competition from other biotech firms and tech-driven drug discovery companies, which may challenge its ability to maintain a competitive edge [14] - The company’s investigational candidates are still in early stages, raising concerns about the timeline for commercialization [15] Valuation Metrics - RXRX is trading at a premium price/book value ratio of 1.88 compared to the industry average of 1.20, although it is below its five-year mean of 3.65 [16] - Loss estimates for 2025 remain constant at $1.34 per share, while 2026 estimates have narrowed from $1.20 to $1.17 [19] Future Outlook - The company is positioned as a leader in AI-driven drug discovery, with a strong focus on Precision Oncology and Rare Diseases, which could enhance shareholder value if pipeline candidates are successfully developed [22] - Recent setbacks in the pipeline are viewed as temporary, and the decline in stock price may present an attractive entry point for new investors [23]

Core Viewpoint - Recursion Pharmaceuticals experienced a significant stock decline of 24% following disappointing first-quarter earnings and concerns over federal research funding cuts impacting the biotech industry [1][2][3]. Financial Performance - Recursion reported an earnings-per-share (EPS) loss of $0.50 on sales of $14.75 million, slightly beating Wall Street's expectations but falling short of the forecasted sales of $14.98 million [2]. Development Pipeline - The company announced it would reduce its development pipeline significantly to cut costs, indicating a strategic shift in its research focus [2][4]. Industry Challenges - The Trump administration's proposed cuts to the National Institutes of Health (NIH) and other research funding sources are expected to make capital raising more difficult for biotech firms, as indicated by a survey of industry leaders [3]. Long-term Viability - Recursion is heavily investing in research and development while operating at a loss, suggesting that it will require external funding to sustain its operations and achieve long-term profitability [4]. Investment Outlook - Despite the potential of Recursion's innovative use of AI in drug discovery, the company faces significant uncertainty, making it a suitable investment only for aggressive, risk-tolerant investors [5].

Shares of Recursion Pharmaceuticals (RXRX -11.57%) are tumbling on Tuesday. The stock lost 10.3% as of 2:50 p.m. ET and was down by as much as 11.8% earlier in the day. The move comes as the S&P 500 and Nasdaq Composite both slipped by 0.6%.The data from an April survey revealed Tuesday showed that the biotech industry is fearful that President Donald Trump's federal research cuts will make raising capital more challenging. This comes just a day after Recursion revealed its disappointing first-quarter earni ...

Core Viewpoint - Recursion Pharmaceuticals reported a wider-than-expected loss in Q1 2025, leading to a significant decline in its stock price due to disappointing financial results and pipeline setbacks [1][2][5]. Financial Performance - The company reported a loss of 50 cents per share, compared to the Zacks Consensus Estimate of a loss of 44 cents, and a loss of 39 cents per share in the same quarter last year [1]. - Total revenues for the quarter were $14.7 million, a 7% increase year over year, but below the Zacks Consensus Estimate of $20 million [2]. - Research and development (R&D) expenses surged 92% to $129.6 million, driven by agreements for upgrading its therapeutic development platform and a business combination with Exscientia [3]. - General and administrative (G&A) expenses rose 74% to $54.7 million, influenced by the inclusion of G&A expenses from the Exscientia business combination [4]. - The company had cash and equivalents of $509 million as of March 31, 2025, down from $603 million at the end of 2024, which is expected to sustain operations into mid-2027 [5]. Pipeline Developments - Recursion Pharmaceuticals discontinued the development of its lead candidate, REC-994, and REC-2282 due to unfavorable efficacy results from mid-stage studies [7]. - The company also halted the mid-stage study of REC-3964 for treating clostridioides difficile infection, opting to focus on areas with greater unmet needs [8]. - The company is now concentrating on other candidates, including REC-4881, which showed a preliminary median 43% reduction in polyp burden in a phase Ib/II study [9][10]. - REC-1245 is being evaluated in the phase I/II DAHLIA study for biomarker-enriched solid tumors and lymphoma, with data expected in the first half of 2026 [12].

Recursion Pharmaceuticals (RXRX -15.70%) didn't have a fine start to the working week on Monday, at least as far as its stock was concerned. Investors traded out of it following the clinical-stage biotech's first-quarter earnings release and business update, and the share price was down by 15% in mid-session trading. The S&P 500 index was doing comparatively better, with a 0.3% decline. Light revenue and a deepening net lossFor the quarter, Recursion -- which although a clinical-stage company earns some coi ...

Recursion Pharmaceuticals (RXRX) Q1 2025 Earnings Call May 05, 2025 08:00 AM ET Company Participants Chris Gibson - Co-Founder & CEONajat Khan - Chief R&D Officer, Chief Commercial Officer and DirectorBen Taylor - CFO & President Recursion UK Chris Gibson Hi, everybody. My name is Chris Gibson, cofounder and CEO of Recursion, and I'm delighted to welcome you to our learnings call this morning. We're gonna go ahead and get started. Perfect. So, of course, important to note that we're gonna be providing forwa ...

Recursion Pharmaceuticals (RXRX) Q1 2025 Earnings Call May 05, 2025 08:00 AM ET Company Participants Chris Gibson - Co-Founder & CEONajat Khan - Chief R&D Officer, Chief Commercial Officer and DirectorBen Taylor - CFO & President Recursion UK Chris Gibson Hi, everybody. My name is Chris Gibson, cofounder and CEO of Recursion, and I'm delighted to welcome you to our learnings call this morning. We're gonna go ahead and get started. Perfect. So, of course, important to note that we're gonna be providing forwa ...

Recursion Pharmaceuticals (RXRX) came out with a quarterly loss of $0.50 per share versus the Zacks Consensus Estimate of a loss of $0.44. This compares to loss of $0.39 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of -13.64%. A quarter ago, it was expected that this biotechnology company would post a loss of $0.36 per share when it actually produced a loss of $0.53, delivering a surprise of -47.22%.Over the last four quarters ...

Recursion Pharmaceuticals (RXRX) Q1 2025 Earnings Call May 05, 2025 08:00 AM ET Speaker0 Hi, everybody. My name is Chris Gibson, cofounder and CEO of Recursion, and I'm delighted to welcome you to our learnings call this morning. We're gonna go ahead and get started. Perfect. So, of course, important to note that we're gonna be providing forward looking information today, so please understand all of these important caveats. So I wanna begin by just talking a little bit about Recursion's mission, which is to ...