SITE Centers Corp. (NYSE:SITC) is included among the 13 Dividend Stocks with Over 8% Yield. Piper Sandler Refreshes Estimates on SITE Centers (SITC) After Quarterly Update On January 5, Piper Sandler analyst Alexander Goldfarb lowered SITE Centers Corp. (NYSE:SITC)’s price target to $8 from $10 and kept an Overweight rating on the stock. The firm said, “out with the old estimates and in with the new,” as it carried out its standard post-quarter update. This process mainly reflects recent company announce ...

Group 1 - Site Centers (SITC) announced the sale of Perimeter Pointe for approximately $48 million, prior to closing costs, prorations, and other closing adjustments [1] - The company did not use any proceeds from the sale to repay mortgage debt, as it had already repaid its existing mortgage facility in full on December 18 [1]

Core Viewpoint - SITE Centers Corp. has successfully sold $3.7 billion of assets since the announcement of the spin-off of Curbline Properties, with proceeds primarily used for debt repayment and shareholder distributions [2][3]. Disposition Activity - The company has sold 64 retail properties and one land parcel, declaring over $380 million in distributions to shareholders, equating to $7.39 per share since the spin-off announcement [1][2]. - As of December 4, 2025, SITE Centers owns 11 wholly-owned properties and has interests in 11 joint venture properties, with ongoing negotiations for the sale of four wholly-owned properties and one joint venture property [3]. Future Plans - SITE Centers plans to market all remaining wholly-owned retail properties, subject to market conditions, and expects to declare further distributions from sale proceeds after addressing outstanding debts and expenses [3][4]. - The company intends to maintain its common shares on the New York Stock Exchange, but may voluntarily delist to reduce operating expenses and maximize shareholder distributions [4]. Performance of Curbline Properties - Shares of Curbline Properties, distributed to SITE shareholders, have outperformed the FTSE NAREIT Shopping Center Index by over 1,550 basis points, indicating strong market demand and value creation [2].

Core Points - SITE Centers Corp. completed the sale of four properties for a total of approximately $263.6 million, with proceeds used to repay mortgage indebtedness [1][2] - The properties sold include East Hanover Plaza, Southmont Plaza, Stow Community Center, and Nassau Park Pavilion [1][2] - The company is a self-administered and self-managed REIT, publicly traded on the NYSE under the ticker symbol SITC [3] Summary by Category Property Sales - East Hanover Plaza, Southmont Plaza, and Stow Community Center were sold for approximately $126.0 million, with $38.2 million of proceeds used to repay mortgage debt [1] - Nassau Park Pavilion was sold for approximately $137.6 million, with $98.4 million of proceeds applied to fully repay a mortgage loan and an additional $7.0 million paid as a make-whole premium [2] Company Overview - SITE Centers is an owner and manager of open-air shopping centers, operating as a fully integrated real estate company [3] - The company provides additional information on its operations and investor news through its website [3]

Core Points - SITE Centers Corp. announced the sale of Paradise Village Gateway in Phoenix, AZ for $28.5 million, excluding closing costs and adjustments [1] - A portion of the net proceeds from the sale was utilized to repay $24.3 million of mortgage debt [1] Company Overview - SITE Centers Corp. is an owner and manager of open-air shopping centers, operating as a self-administered and self-managed REIT [2] - The company is publicly traded on the New York Stock Exchange under the ticker symbol SITC [2]

Core Insights - Akeso, Inc. has presented preclinical research data for its novel monoclonal antibody AK135, targeting IL-1RAP, at the 40th Annual Meeting of the Society for Immunotherapy of Cancer [1][2] Group 1: Product Development - AK135 effectively targets IL-1RAP and blocks three key pro-inflammatory signaling pathways—IL-1, IL-33, and IL-36, providing significant pain relief in neuropathy with good tolerability and safety profiles [2][6] - The antibody is currently in Phase I clinical trials for treating chemotherapy-induced peripheral neuropathy (CIPN) [6][11] - Preclinical studies indicate that AK135 shows dose-dependent efficacy in alleviating neuropathic pain and maintains stable body weight in treated models without significant toxicity [8] Group 2: Market Context - CIPN affects 50-90% of chemotherapy-treated patients, with 30-40% progressing to chronic neuropathic pain, highlighting the clinical significance of effective treatment options [5] - Akeso's development of AK135 addresses a critical gap in treatment options for CIPN, as current effective therapies are limited [5][6] Group 3: Company Overview - Akeso is a leading biopharmaceutical company focused on innovative biological medicines, with a robust pipeline of over 50 innovative assets across various disease areas, including cancer and autoimmune diseases [11] - The company has developed a comprehensive end-to-end drug development platform and has 24 candidates in clinical trials, including 15 bispecific/multispecific antibodies [11]

Core Insights - Xilio Therapeutics, Inc. presented new data at the Society for Immunotherapy of Cancer (SITC) 40th Annual Meeting, showcasing the potential of its masked T cell engager programs and tumor-activated therapies, including efarindodekin alfa and vilastobart [1][2] Group 1: Masked T Cell Engager Programs - Xilio is advancing multiple preclinical programs for masked T cell engagers targeting tumor-associated antigens such as PSMA, CLDN18.2, and STEAP1, with a collaboration with AbbVie [3] - The company's masked T cell engager programs utilize advanced formats like ATACR and SEECR, designed to enhance T cell activation and durability [4] - Preclinical data indicate that Xilio's masking technology can significantly expand the therapeutic window for T cell engagers, demonstrating potent anti-tumor activity and reduced systemic toxicity in murine models [5] Group 2: Efarindodekin Alfa - Efarindodekin alfa is an investigational tumor-activated IL-12 being evaluated in a Phase 1/2 clinical trial for patients with advanced solid tumors, with promising Phase 1 data showing a generally well-tolerated safety profile and encouraging anti-tumor activity [7][11] - As of September 2, 2025, 62 patients had been treated, with a median age of 66 years, and most patients had received multiple prior lines of therapy [7] - The treatment demonstrated partial responses in patients with advanced solid tumors, including a 33% decrease in target lesions for HPV-negative head and neck squamous cell carcinoma and a 55% decrease for uveal melanoma [11] Group 3: Vilastobart - Vilastobart is an investigational tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody being evaluated in combination with atezolizumab for advanced solid tumors and MSS mCRC [9][19] - New data presented at SITC suggest that circulating tumor DNA (ctDNA) may serve as an early biomarker for response to vilastobart treatment, with significant reductions in ctDNA correlating with treatment response [10][18] - The combination therapy is currently in Phase 1C and Phase 2 trials, with ongoing evaluations of safety and efficacy [19] Group 4: Development Plans - Xilio plans to nominate development candidates for its CLDN18.2 and STEAP1 programs in late 2025 and early 2026, respectively, with expectations to advance at least two programs into IND enabling studies by 2027 [6] - The company has completed enrollment in the Phase 1A and Phase 1B portions of the clinical trial for efarindodekin alfa, with ongoing evaluations [8][13]

Core Insights - Elicio Therapeutics announced new immunogenicity data from the Phase 2 AMPLIFY-7P trial for ELI-002 7P, showing strong T cell responses in patients with mKRAS pancreatic ductal adenocarcinoma [1][3][6] - The company also presented preclinical data for ELI-004, indicating over 90% tumor eradication in advanced solid tumors [1][8] Group 1: ELI-002 7P Immunogenicity Data - In the AMPLIFY-7P trial, 99% of 90 evaluable patients achieved robust mKRAS-specific T cell responses, with a mean increase of 145-fold over baseline [4][6] - 85% of patients exhibited combined CD4 and CD8 T cell activation, correlating with clinical activity [4][6] - 88% of patients generated responses to their own tumor-specific mutations, indicating personalized immune activation [4][6] Group 2: ELI-004 Preclinical Data - ELI-004 demonstrated complete tumor eradication in over 90% of cases in preclinical studies, with long-term protection against recurrence [3][8] - The efficacy of ELI-004 was linked to the presence of CD8 T cells and effective lymphocyte trafficking from lymph nodes [8] - This approach suggests a promising off-the-shelf strategy for solid tumor immunotherapy [8] Group 3: Presentation Details - The findings will be presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting [2] - The late-breaking abstract for ELI-002 7P highlights its potential to induce robust T cell immunity across diverse HLA backgrounds [6][7] Group 4: Company Overview - Elicio Therapeutics focuses on developing novel immunotherapies targeting high-prevalence cancers, particularly those driven by KRAS mutations [14] - The company's AMP platform aims to enhance immune responses by delivering therapeutics directly to lymph nodes [12][13] - Elicio plans to expand its pipeline to include additional indications for ELI-002 and other candidates targeting different mutations [14]

Core Insights - IO Biotech announced new pre-clinical data for its cancer vaccine candidates IO112 and IO170 at the Society for Immunotherapy of Cancer's 40th Annual Meeting [1][6] - The company plans to file an Investigational New Drug Application for IO112 in 2026, indicating a commitment to advancing its cancer immunotherapy pipeline [2] Group 1: Vaccine Candidates - IO112, targeting arginase 1 (Arg1), shows robust expansion of Arg1-specific T cells that inhibit tumor growth by reprogramming immune suppressive myeloid cells [3][5] - IO170, targeting Transforming Growth Factor (TGF)-β, activates TGF-β-specific T cells to promote anti-tumor activities, demonstrating significant tumor growth inhibition and reduced lung metastasis [4][5] Group 2: Research and Development - The data presented highlight the unique approach of IO Biotech's T-win® platform, which targets both tumor cells and immune-suppressive cells in the tumor microenvironment [5][8] - The company is advancing its lead cancer vaccine candidate, Cylembio®, in clinical trials while developing additional candidates through preclinical stages [8]

Core Insights - Werewolf Therapeutics presented preclinical data at the 2025 Society for Immunotherapy of Cancer's Annual Meeting, showcasing advancements in their INDUCER™ T Cell Engager Platform designed to enhance safety and efficacy in cancer treatment [1][2][3] Group 1: Technology and Platform - The proprietary PREDATOR platform utilizes clinically validated protease-cleavable linkers for tumor-selective activation, leading to the development of three clinical-stage INDUKINE candidates [2][6] - The INDUCER molecules employ a novel masking strategy that prevents systemic T cell activation and cytokine release, activating only in the presence of human tumor tissue [5][6] Group 2: Preclinical Findings - A sequential dosing regimen of mWTX-330 (IL-12) followed by WTX-124 (IL-2) demonstrated superior tumor-killing ability in preclinical models, suggesting enhanced immune response and tolerability [5][6] - Real-time pharmacokinetic data confirmed that WTX-124 selectively activates within tumors, with minimal active cytokine released into the plasma, validating the prodrug design [5][6] Group 3: Company Overview - Werewolf Therapeutics focuses on developing therapeutics that stimulate the immune system for cancer and immune-mediated conditions, with advanced candidates WTX-124 and WTX-330 targeting solid tumors [6]