Financial Performance - As of September 30, 2025, Senti Bio held cash and cash equivalents of approximately $12.2 million, a decrease from $48.3 million as of December 31, 2024[9]. - Research and development expenses for Q3 2025 were $10.5 million, up from $8.7 million in Q3 2024, reflecting a 20.7% increase primarily due to higher external services and personnel-related costs[9]. - General and administrative expenses decreased slightly to $6.4 million in Q3 2025 from $6.6 million in Q3 2024, a reduction of 3%[9]. - The net loss for Q3 2025 was $18.1 million, or $0.69 per share, compared to a net loss of $28.9 million, or $6.31 per share, in Q3 2024[9][16]. - Total operating expenses for the nine months ended September 30, 2025, were $50.1 million, compared to $44.9 million for the same period in 2024, indicating an increase of 11.5%[16]. - Senti Bio's accumulated deficit as of September 30, 2025, was approximately $344.1 million, up from $297.1 million at the end of 2024[14]. - The total assets of Senti Bio as of September 30, 2025, were $52.7 million, a decrease from $97.8 million as of December 31, 2024[14]. Clinical Development - Senti Bio plans to present updated clinical data for the SENTI-202 study at the American Society of Hematology Annual Meeting in December 2025, highlighting the efficacy and safety of its Logic Gate technology[5][2]. - The company is focused on expanding its clinical development for SENTI-202, particularly in enrolling additional patients with relapsed/refractory acute myeloid leukemia (AML)[2]. Investor Relations - Senti Bio's participation in various investor conferences aims to increase market awareness and visibility among the investor and scientific communities[4].

Core Insights - Senti Biosciences, Inc. is focused on advancing its SENTI-202 clinical development for relapsed/refractory acute myeloid leukemia (AML), with significant milestones achieved in Q3 2025 [2][3] - The company plans to present updated clinical data at the upcoming ASH Annual Meeting, emphasizing the efficacy and safety of its Logic Gate technology [2][7] Financial Results - As of September 30, 2025, Senti Bio reported cash and cash equivalents of approximately $12.2 million, a decrease from $48.3 million as of December 31, 2024 [7][13] - Research and development expenses for Q3 2025 were $10.5 million, up from $8.7 million in Q3 2024, primarily due to increased external services and personnel-related costs [7][14] - General and administrative expenses decreased slightly to $6.4 million in Q3 2025 from $6.6 million in Q3 2024 [7][14] - The net loss for Q3 2025 was $18.1 million, or $0.69 per share, compared to a net loss of $28.9 million in Q3 2024 [7][15] Pipeline and Corporate Highlights - The company is actively enrolling additional patients for the SENTI-202 trial and has achieved important milestones in its dose expansion phase [2][3] - Senti Bio's Gene Circuit platform is designed to enhance precision in targeting cancer cells while sparing healthy tissue, addressing a significant challenge in cancer treatment [6][8] - The company has participated in various investor conferences to increase market awareness and visibility among the scientific community [4][7]

Core Insights - Senti Biosciences, Inc. is set to present its SENTI-202 clinical program at the 67th American Society of Hematology Annual Meeting, showcasing advancements in its Logic Gate technology for treating relapsed/refractory Acute Myeloid Leukemia (AML) [1][4] Company Overview - Senti Bio is a clinical-stage biotechnology company focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [1][8] - The company aims to engineer Gene Circuits that can precisely target and kill cancer cells while sparing healthy cells, enhancing specificity and control in treatment [8] Product Details - SENTI-202 is the first Logic Gated off-the-shelf CAR-NK cell therapy designed to selectively target and eliminate CD33 and/or FLT3 expressing hematologic malignancies, such as AML and myelodysplastic syndrome (MDS) [3][5] - The therapy incorporates an OR GATE for activating CAR that targets CD33 and FLT3, and a NOT GATE to protect healthy cells expressing EMCN, potentially widening the therapeutic window [5] - SENTI-202 also includes calibrated-release IL-15 to enhance cell persistence and activity [5] Clinical Program - The upcoming presentations will provide updated clinical results, demonstrating deep and durable remission rates and a strong safety profile for SENTI-202 in treating relapsed/refractory AML [4] - The oral session will present promising results from an ongoing Phase I multicenter study, while the poster session will provide correlative data consistent with clinical activity [2][4] Market Context - AML is a prevalent blood cancer with an estimated 22,010 new cases in the U.S. in 2025, and a five-year survival rate of approximately 32.9% at diagnosis [7] - There is a significant unmet need for effective treatments for relapsed/refractory AML, where median overall survival is typically around five months [7]

Summary of Senti Biosciences FY Conference Call Company Overview - **Company**: Senti Biosciences (NasdaqCM:SNTI) - **Lead Program**: Senti 202, an off-the-shelf allogeneic CAR NK cell therapy targeting acute myeloid leukemia (AML) [2][3][31] Industry Context - **Focus Area**: Oncology, specifically targeting cancer cells while sparing healthy cells - **Challenge**: Many cancers lack a single target that is unique to cancer cells, complicating treatment options [2][5][33] Core Technology - **Logic Gate Technology**: Utilizes a NOT gate mechanism to protect healthy cells while targeting cancer cells [4][39] - **Targets**: Senti 202 targets CD33 and FLT3, which are expressed in over 95% of AML patients [9][38] Clinical Development - **Current Phase**: Phase 1 dose expansion study, actively enrolling patients [3][40] - **Patient Population**: Focus on relapsed/refractory AML patients, with a disease burden of approximately 20,000 patients per year in the U.S. [6][34] - **Efficacy Data**: Preliminary data shows an overall response rate (ORR) of 71% in evaluable patients, with 57% achieving a composite complete response (CR) [15][45] Safety Profile - **Adverse Events**: Generally well tolerated with no serious adverse events (SAEs) or dose-limiting toxicities (DLTs) attributed to Senti 202 [43][44] - **Lymphodepletion Effects**: Expected drop in healthy blood cell counts post-lymphodepletion, followed by recovery [14][50] Future Outlook - **Upcoming Data**: Additional phase 1 data expected by the end of the year, with a focus on durability and correlative data using CyTOF analyses [26][59] - **Expansion Potential**: Opportunities to apply logic gate technology to newly diagnosed AML, myelodysplastic syndromes (MDS), and solid tumors [21][52] Key Takeaways - **Unmet Need**: Significant opportunity exists in the relapsed/refractory AML space, especially for patients who do not qualify for existing therapies [35][36] - **Regulatory Pathway**: Potential for FDA breakthrough designation based on precedents set by other therapies in the same space [52] - **Technology Versatility**: Logic gate technology may be adapted for various cancer types, enhancing treatment specificity and efficacy [22][56] Conclusion - Senti Biosciences is positioned to make significant advancements in the treatment of AML through its innovative logic gate technology, with promising early clinical data and a clear path for future development [20][24]

Core Insights - Senti Biosciences, Inc. is set to present at Chardan's 9th Annual Genetic Medicines Conference on October 21, 2025, in New York, NY [1] - The company is focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [1][3] - Management will also engage in one-on-one meetings with qualified investors during the conference [2] Company Overview - Senti Bio is a clinical-stage biotechnology company targeting incurable diseases through innovative cell and gene therapies [3] - The company utilizes a synthetic biology platform to engineer Gene Circuits aimed at precisely targeting and killing cancer cells while sparing healthy cells [3] - Senti Bio's pipeline includes cell therapies designed for challenging liquid and solid tumor indications, with preclinical evidence supporting the efficacy of Gene Circuits in NK and T cells [3] Additional Information - Investors and the public can access more information about Senti Bio through its website and social media platforms [4] - The company emphasizes the importance of its online communications for investor relations and public disclosures [4]

Core Insights - Senti Biosciences, Inc. will present at BioJapan on October 9, 2025, showcasing its innovative Gene Circuit platform for cell and gene therapies [1] - The presentation will be led by CEO Timothy Lu, and the company will also engage in one-on-one meetings with investors during the conference [1] - BioJapan is recognized as Asia's leading bio-industry partnering event, promoting collaboration and innovation in biotechnology [3] Company Overview - Senti Bio focuses on developing next-generation cell and gene therapies aimed at treating incurable diseases through its proprietary synthetic biology platform [4] - The company's Gene Circuits are engineered to selectively target and kill cancer cells while sparing healthy cells, enhancing treatment specificity and control [4] - Senti Bio's pipeline includes therapies targeting both liquid and solid tumors, with preclinical evidence supporting the efficacy of its Gene Circuits in NK and T cells [4]

Summary of Senti Biosciences Conference Call Company Overview - **Company**: Senti Biosciences (NasdaqCM:SNTI) - **Industry**: Biotechnology, specifically focused on cell therapy Core Points and Arguments 1. **Logic-Gated Cell Therapy**: Senti Biosciences specializes in logic-gated cell therapy, which allows engineered cells to perform multiple functions based on various inputs from the host cell [1][2] 2. **Lead Program - SENTI-202**: The lead program, SENTI-202, is a first-in-class therapy targeting acute myeloid leukemia (AML), particularly affecting individuals aged 65 and older [2][5] 3. **Orphan Drug Designation**: SENTI-202 has received orphan drug designation, indicating its potential to address a significant unmet medical need in AML [2] 4. **Clinical Trial Progress**: Positive preliminary efficacy data has been demonstrated in the ongoing phase 1 clinical trial, with additional data expected by the end of the year [2][5] 5. **AML Statistics**: Approximately 20,000 to 21,000 Americans are diagnosed with AML annually, with a median survival of 5.3 months for those who do not respond to first-line therapy [5][6] 6. **Challenges in AML Treatment**: The heterogeneity of AML and the presence of therapy-resistant leukemic stem cells (LSCs) pose significant challenges in developing effective therapies [7][8] 7. **Mechanism of Action**: SENTI-202 utilizes a unique logic gate mechanism to selectively kill AML cells while sparing healthy cells, addressing the issue of shared targets between LSCs and healthy hematopoietic stem cells [9][11] 8. **NK Cell Utilization**: The therapy employs natural killer (NK) cells, which can be used across different patients without the risk of graft-versus-host disease, and have shown a response rate of about 20% in non-engineered forms [10][15] 9. **Efficacy Data**: In the RP2D cohort, 67% of patients achieved complete remission (CR), with 100% being measurable residual disease (MRD) negative, indicating a strong response to treatment [18][19] 10. **Safety Profile**: The safety profile of SENTI-202 is favorable, with no grade 3 adverse events reported and manageable infusion-related reactions [18][21] Additional Important Content 1. **Gene Circuit Design**: The gene circuit in SENTI-202 includes an OR logic gate for targeting multiple antigens and a NOT logic gate to protect healthy cells from being killed [11][13] 2. **Manufacturing Process**: The manufacturing process for SENTI-202 is off-the-shelf, allowing for immediate shipment of cells upon patient approval, which enhances operational efficiency [14] 3. **Future Plans**: The company plans to confirm the recommended phase 2 dose (RP2D) and expand the patient cohort, with further data presentation anticipated by the end of the year [21][22] This summary encapsulates the key points discussed during the conference call, highlighting Senti Biosciences' innovative approach to treating AML through its SENTI-202 program and the promising data emerging from its clinical trials.

Company Overview - Senti Biosciences, Inc. is a clinical-stage biotechnology company focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [2] - The company aims to create new medicines that can precisely target and kill cancer cells while sparing healthy cells, enhancing specificity to target tissues, and allowing for control even after administration [2] Upcoming Presentation - Kanya Rajangam, M.D., Ph.D., President, Head of Research & Development and Chief Medical Officer of Senti, will present at the MedInvest Biotech & Pharma Conference on September 24, 2025, at 9:55 AM PT [1] - A live webcast of the presentation will be available on the company's website [2] Investor Engagement - Management will be available for one-on-one meetings with qualified members of the investor community registered for the conference [2] - The company encourages investors and the public to review information posted on its website and social media platforms regularly [3]

Core Insights - Senti Biosciences, Inc. is a clinical-stage biotechnology company focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [1][3] - The company will present at the H.C. Wainwright 27th Annual Global Investment Conference on September 8, 2025, at 2:00 PM ET [1] - Senti Bio's Gene Circuits are engineered to target cancer cells while sparing healthy cells, enhancing specificity, and allowing for post-administration control [3] Company Overview - Senti Bio is dedicated to creating new medicines for patients with incurable diseases through its synthetic biology platform [3] - The company's pipeline includes cell therapies designed to address challenging liquid and solid tumor indications [3] - Preclinical studies have shown the effectiveness of Senti's Gene Circuits in both NK and T cells, with potential applications beyond oncology [3] Investor Engagement - Management will be available for in-person one-on-one meetings with qualified investors during the conference [2] - A live video webcast of the presentation will be accessible on the company's website, with a replay available for 90 days [2]

Company Overview - Senti Biosciences, Inc. is a clinical-stage biotechnology company focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [1][3] - The company aims to create new medicines that can precisely target and kill cancer cells while sparing healthy cells, enhancing specificity to target tissues, and allowing for control even after administration [3] Upcoming Presentation - Senti Bio will present at the Webull Financial Corporate Connect Webinar Series: Biotech/MedTech on August 19, 2025, at 2:20 PM ET [1] - The presentation will be led by Timothy Lu, M.D., Ph.D., Co-Founder and CEO of Senti Bio [1] Technology and Pipeline - Senti Bio's pipeline includes cell therapies engineered with Gene Circuits targeting challenging liquid and solid tumor indications [3] - The Gene Circuits have shown preclinical efficacy in both NK and T cells, with potential applications extending beyond oncology [3]