UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 | For the transition period from _____________________________to_____________________________________________________ | | | --- | --- | | Commission File Number: 001-40603 | | | TSCAN THERA ...

Exhibit 99.1 TScan Therapeutics Reports First Quarter 2024 Financial Results and Provides Corporate Update First patient dosed in Phase 1 clinical trial for the treatment of solid tumors; initial data anticipated in 2024 All treatment-arm patients in the Phase 1 heme program remain relapse-free with no detectable disease, with a median follow-up of >10 months Closed upsized underwritten public offering with gross proceeds of $167.8 million, extending runway into the fourth quarter of 2026 WALTHAM, Mass., Ma ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 (Exact name of Registrant as specified in its Charter) Delaware 82-5282075 (State or other jurisdiction of incorporation or organization) 830 Winter Street Waltham, Massachusetts 02451 (Address of principal executive offices) (Zip Code) For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT T ...

Exhibit 99.1 TScan Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update Presented updated data from ongoing Phase 1 study of TSC-100 and TSC-101 for the treatment of heme malignancies at the Tandem Meetings of ASTCT and CIBMTR; 8/8 (100%) patients in treatment arms are relapse-free and show complete donor chimerism Announced the clearance of two additional INDs for Solid Tumor Program: TSC-201-B0702 targeting MAGE- C2 on HLA-B*07:02 and TSC-204-A0101 targetin ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _____________________________to_____________________________________________________ Commission File Number: 001-40603 TSCAN THERAPEUTICS, INC. (Exact nam ...

1 This presentation and the accompanying discussion contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, express or implied statements regarding the Company's plans, progress, and timing relating to the Company's solid tumor programs and the presentation of data, the Company's current and future research and development plans or expectations, the structure, timing and success of the Company's planned preclinical develop ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _____________________________to_____________________________________________________ Commission File Number: 001-40603 TSCAN THERAPEUTICS, INC. (Exact name of ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _____________________________to_____________________________________________________ Commission File Number: 001-40603 TSCAN THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 82-5282075 (State or other jurisdiction of incorporation or organization) 830 Winter Street, Walt ...

• Endpoints TScan Therapeutics, Inc. 30 1 2 3 Archival sample <6mo OR fresh biopsy Targets TSC-200 TSC-203 TSC-202 TSC-204 A*02:01A*01:01A*03:01B*07:02C*07:02 TSC-201 A*24:02 TSC-205 HPV16 Target-202 Target-201 PRAME MAGE-A1 Target-205 10+ TCRs in the clinic by the end of 2024 the early stages of building the ImmunoBank 1 2 3 4 5 6 7 8 9 0 20 40 60 80 100 Eligible patients (%) Melanoma -single NSCLC-single TScan Therapeutics, Inc. 33 TCR-T uniquely addresses myeloid leukemias Not addressable by CAR-T therap ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ____________________________to_____________________________________________________ Commission File Number 001-40603 TSCAN THERAPEUTICS, INC. (Exact name of Regist ...