Core Insights - Investment strategist Shay Boloor has identified ten sub-$10 billion market-cap companies poised to benefit from long-term trends leading into 2026, focusing on essential platforms and hard infrastructure rather than short-term narratives [1][19] Company Summaries - **Ondas Holdings (NASDAQ: ONDS)**: Developing a wireless connectivity layer for industrial and autonomous drones, with strong revenue growth momentum and a year-to-date stock increase of over 230% [2][3] - **Cipher Mining (NASDAQ: CIFR)**: Transitioning to a digital infrastructure owner with large-scale power and data-center assets, stock up over 250% year to date [6] - **Jumia Technologies (NYSE: JMIA)**: Refining its e-commerce and logistics model in Africa, with improved order volumes and a stock gain of about 215% [7] - **DigitalOcean Holdings (NYSE: DOCN)**: Regaining investor confidence with strong earnings and positioning as an AI inference cloud, stock up 40% year to date [8] - **IREN Limited (NASDAQ: IREN)**: Expanding compute capacity with record profitability and a nearly 285% stock increase [9] - **ClearPoint Neuro (NASDAQ: CLPT)**: Advancing image-guided navigation platforms for neurosurgeons, with a stock decrease of 18% year to date [10] - **Eos Energy Enterprises (NASDAQ: EOSE)**: Developing zinc-based energy storage systems for high-load environments, stock up 170% year to date [11] - **Navitas Semiconductor (NASDAQ: NVTS)**: Supplies gallium nitride power chips for AI data centers, stock up 145% year to date despite near-term pressures [14] - **Viking Therapeutics (NASDAQ: VKTX)**: Developing GLP-1 therapies for obesity and diabetes, with a stock decrease of about 10% [16] - **TransMedics Group (NASDAQ: TMDX)**: Scaling its organ care system with a focus on logistics, stock up about 90% [18]

Core Viewpoint - The article discusses the current landscape of heavily shorted stocks, highlighting the reasons traders engage in short selling and the potential for short squeezes as investment opportunities [2][3][4]. Summary by Sections Heavily Shorted Stocks - Stocks become heavily shorted when experienced traders and institutional investors believe the company is fundamentally overvalued, anticipating a price decline [2]. - Short sellers borrow shares, sell them at high prices, and aim to repurchase them at lower prices for profit, indicating a strong conviction about the company's risks [3]. Current Market Data - As of December 10, 2025, the top 10 most shorted stocks with market caps above $2 billion and free floats above 5 million are listed, ranked by short interest percentage [5]. - The most heavily shorted stock is Lucid Group, Inc. (NASDAQ: LCID) with a short interest of 52.70%, followed by Avis Budget Group, Inc. (NASDAQ: CAR) at 51.53% and Choice Hotels International, Inc. (NYSE: CHH) at 49.05% [6][7]. Market Characteristics - Heavily shorted stocks often reflect a battleground between negative fundamentals and speculative trading, where short squeezes can lead to significant, rapid gains but also come with high risk and volatility [8]. - Monitoring short interest can help identify potential short squeeze candidates, although timing such trades is challenging [8].

Group 1: TransMedics Group - TransMedics Group is innovating the organ transplant market by addressing the challenges of organ storage and preservation, which traditionally has poor outcomes with cold storage methods [2][3] - The company developed the Organ Care System (OCS), which maintains organs in optimal condition for transplant, achieving a usage rate of 87% for lungs compared to 23% for cold storage, leading to fewer post-transplant complications [3] - In Q3, TransMedics reported revenue of $143.8 million, a 32% increase year-over-year, with net earnings per share rising to $0.66 from $0.12 [6] - The company is expanding its National OCS Program (NOP) to improve organ procurement and transport, which has been crucial for business growth [8] - TransMedics has partnered with Mercedes-Benz for ground transport in Italy, aiming to enhance its service in Europe, which could positively impact revenue [9] - The company is also developing a next-generation OCS system for other organs, anticipating steady growth in organ transplants over the coming years [10] Group 2: Abivax Société Anonyme - Abivax is a clinical-stage biotech company based in France, focusing on the development of obefazimod for ulcerative colitis (UC), which has shown promising late-stage clinical trial results [11] - The competitive landscape for UC treatments includes established therapies from major pharmaceutical companies, but Abivax's obefazimod could target a larger patient pool, particularly those with inadequate responses to existing therapies [12][13] - The stock has surged over 1,000% since January, with a market cap of approximately $9 billion, indicating strong investor interest [14][15] - Abivax plans to submit for regulatory approval in the U.S. in the second half of 2026, contingent on the success of ongoing trials, and is also exploring other indications for obefazimod, such as Crohn's disease [15] - Despite the potential for obefazimod to achieve blockbuster status, there are risks associated with regulatory and clinical trial outcomes, making it a high-risk investment [16][17]

Core Thesis - TransMedics Group, Inc. (TMDX) is viewed positively due to its strong revenue growth, operational efficiencies, and potential for international expansion, despite a recent minor revenue miss leading to initial stock volatility [1][2][5]. Financial Performance - TMDX reported Q3 2025 revenue of $143.8 million, reflecting a 32% year-over-year growth, marking the 15th consecutive quarter of over 30% growth [2][3]. - The company experienced a significant increase in operating income, which surged nearly fivefold to $23.3 million, resulting in a 16.2% operating margin [3]. - Gross margins expanded by 290 basis points to 59%, driven by operational efficiencies and fleet optimization [3]. Market Expansion - International sales are currently modest at $3.6 million, but TMDX is preparing for expansion with the National Organ Care System Program set to launch in Italy in the first half of 2026, aiming for broader European engagement by FY27 [3][4]. - The upcoming Gen 3 Organ Care System platform and the 2027 launch of the kidney program are expected to significantly increase the addressable market [4]. Valuation and Investment Case - TMDX's forward revenue multiple stands at 6.8x, which is considerably lower than peers, indicating it may be undervalued relative to recent sector acquisitions [5]. - The company's operational momentum, expanding competitive moat, and multi-year growth visibility support a strong long-term investment case [5][6].

Company Overview - TransMedics Group specializes in the Organ Care System (OCS), a portable organ perfusion and monitoring platform for donor hearts, lungs, and livers, generating revenue from both device sales and consumables used in organ preservation procedures [8][9] - The company has a market capitalization of $4.17 billion and reported a revenue of $566.35 million for the trailing twelve months (TTM) [7] - TransMedics has experienced a significant 1-year price change of 103%, reflecting strong market performance [7] Recent Executive Transaction - Director Edward Basile executed a cashless exercise of 4,142 stock options, selling all resulting shares for approximately $540,300 on October 29, 2025 [1][2] - This sale represented 59.1% of Basile's direct holdings prior to the transaction, reducing his ownership to 2,866 shares, which is 0.0084% of the total shares outstanding [4] - The transaction size is notable as it marks the highest proportion of direct holdings sold in a single transaction by Basile during the analyzed period [5] Market Context - The shares were sold at a price of approximately $130.45 per share, with TransMedics shares delivering a total return of 51.8% over the prior year [6] - As of November 3, 2025, the stock price was $124.72, indicating a slight decline from the transaction price [6] Financial Performance - TransMedics reported a 32% increase in revenue for the third quarter, with significant expansion in profit margins [12] - Analysts maintain a buy rating on the stock, citing the company's dedicated airline fleet and future product developments, such as kidney transplant technology, as positive factors [12]

Summary of TransMedics Group FY Conference Call (December 02, 2025) Company Overview - **Company**: TransMedics Group (NasdaqGM:TMDX) - **Industry**: Medical Technology, specifically organ transplantation Key Points and Arguments Machine Perfusion Adoption - Current adoption of machine perfusion for liver transplants is approximately **40%** [14] - The company aims to increase this adoption to **80-90%** through aggressive efforts and data publication [14] - Significant survival differences and improvements in post-transplant complication rates are associated with the use of OCS machine perfusion [14] Data and Growth Potential - Major publications from liver registry data are expected in the **first half of 2026** [17] - DCD (Donation after Circulatory Death) liver adoption is around **60%**, while DBD (Donation after Brain Death) is only in the mid-20s, indicating room for growth [18] - Approximately **70%** of DCD livers are currently discarded, presenting a significant opportunity for market expansion [18] Transplant Goals - The company is confident in achieving a target of **10,000 transplants by 2028**, regardless of additional growth opportunities [23] - The growth strategy includes increasing utilization in existing centers and onboarding new centers [26] Competitive Landscape - The company welcomes competition, viewing it as a means to maintain market integrity [131] - TransMedics has a strong balance sheet with nearly **$500 million**, which will be invested back into the business [131] Clinical Trials and New Technologies - Enrollment for heart clinical trials has begun, with expectations for lung trials to start by early January [38] - The company is optimistic about replicating the success seen in liver transplants for heart and lung transplants [42] - A new **Gen3 OCS** system is in development, aimed at significantly improving efficiency and reliability for future transplant volumes [126] Kidney Transplant Market - The company plans to enter the kidney transplant market in **2027**, which has a potential volume of **23,000** transplants annually [100] - Current kidney utilization rates are low at **60-65%**, and complications post-transplant are high, indicating a need for improvement [105][106] Financial Outlook - The company aims to achieve an operating margin of **30% by 2028**, driven by growth, disciplined operating expenses, and margin protection [69][136] - There may be a slight impact on gross margins due to costs associated with clinical trials [66] Operational Efficiency - The company is working on increasing the efficiency of its transportation logistics, including double-shifting pilots to maximize jet utilization [73][80] - The goal is to run jets more efficiently, potentially reducing the need for additional aircraft purchases [78] Conclusion - TransMedics Group is positioned for significant growth in the organ transplant market, with a focus on increasing adoption of machine perfusion technology, expanding into new organ markets, and maintaining a strong financial outlook. The company is actively working on clinical trials and new technologies to enhance transplant outcomes and operational efficiency.

Group 1: MercadoLibre - MercadoLibre is the leading player in the Latin American e-commerce and fintech markets, with a compound annual growth rate exceeding 30% over the past five and ten years [2] - The stock has recently declined approximately 20% from its all-time high due to increased competition from Amazon in Latin America [3] - E-commerce penetration in Latin America is still in the mid-teens as a percentage of total retail sales, indicating significant growth potential [5] Group 2: TransMedics Group - TransMedics Group is innovating the organ transplantation market with its Organ Care System (OCS), which keeps donor organs alive during transport, addressing issues associated with traditional cold storage methods [6][7] - OCS technology allows for over 80% of donor hearts and lungs to be usable, significantly increasing transplant rates compared to cold storage [9] - The company is expanding into Italy in 2026 and developing a version of OCS for kidneys, which could transform the kidney transplant landscape [11] Group 3: Vertex Pharmaceuticals - Vertex Pharmaceuticals holds a dominant position in the cystic fibrosis market with the only approved therapies targeting the disease's underlying cause [12] - The company is also exploring opportunities in other therapeutic areas, including a non-opioid pain drug that is expected to be a blockbuster [13] - Vertex is advancing its pipeline with plans for regulatory submissions for treatments targeting IgA nephropathy and severe Type 1 diabetes, which could address significant patient populations [15][16]

Core Insights - The article reflects on the importance of learning from past investment decisions, highlighting two stocks that have provided valuable lessons and solid returns [1][2] Group 1: Amazon Case Study - Amazon's Fire Phone was a significant misstep, leading to the decision to sell the stock despite its previous strong performance [3][4] - The stock, which had nearly tripled in value, ultimately became a 14-bagger, demonstrating the importance of long-term thinking and trust in management [4][6] - Key lessons learned include avoiding short-term thinking, trusting founder-led management, and not betting against innovation [6][7] Group 2: TransMedics Group Analysis - TransMedics Group, a provider of Organ Care Systems, was purchased at the beginning of 2023 and initially saw gains before a significant drop in share price following an acquisition announcement [9][10] - Despite initial concerns about the acquisition of Summit Aviation impacting margins, the company’s stock has since tripled from its lows, with sales more than doubling [12][14] - Recent financial performance includes a 32% increase in transplant revenue and a 35% rise in logistics revenue, with a net profit margin of 17% [16] - TransMedics aims to expand its transplant operations significantly and enter new markets, which could provide substantial growth opportunities [16][17]

Group 1 - TransMedics (TMDX) has reached a significant support level and shows potential as a good investment from a technical perspective, having recently broken through the 50-day moving average, indicating a short-term bullish trend [1] - Over the past four weeks, TMDX has gained 11.7%, and it is currently ranked a Zacks Rank 3 (Hold), suggesting the stock could continue to rise [2] - Positive earnings estimate revisions further strengthen the bullish case for TMDX, with no estimates decreasing in the past two months and six estimates increasing, alongside a rise in the consensus estimate [3]

Core Insights - U.S. stocks exhibited mixed performance, with the Nasdaq Composite increasing by over 100 points on Wednesday [1] - Dycom Industries, Inc. reported record third-quarter results, raised its outlook, and announced a significant acquisition [1] Company Performance - Dycom Industries' contract revenues rose by 14.1% year-over-year to $1.45 billion, surpassing analyst expectations of $1.41 billion [1] - The adjusted EPS for Dycom Industries was $3.63, exceeding analyst estimates of $3.20 [1] - Dycom Industries shares increased by 8.1% to $320.17 on Wednesday following the positive results [2] Other Notable Stock Movements - PACS Group, Inc. shares increased by 11.1% to $16.03 [4] - TransMedics Group, Inc. saw a rise of 10.4% to $129.27 [4] - MP Materials Corp. shares jumped by 9.3% to $63.95 after Goldman Sachs initiated coverage with a Buy rating and a $77 price target [4] - BellRing Brands, Inc. surged by 9.1% to $28.64 despite mixed fourth-quarter financial results and FY26 sales guidance below estimates [4] - Hinge Health, Inc. gained 8.2% to $43.93, announcing a $250 million share repurchase program [4] - Kyivstar Group Ltd. rose by 7.6% to $12.06 [4] - Lumentum Holdings Inc. increased by 7.2% to $265.33 after Mizuho Securities initiated coverage with an Outperform rating and a price target of $290 [4]