Core Viewpoint - Veracyte, Inc. has announced preliminary, unaudited financial results for Q4 and the full year of 2025, indicating significant revenue growth compared to 2024 [1] Financial Results - For Q4 2025, Veracyte expects total revenue to be between $138 million and $140 million, reflecting an increase of 16% to 18% compared to the same period in 2024 [1]

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Veracyte, Inc. (Nasdaq: VCYT), a leading cancer diagnostics company, announced today that management will present at the 44th Annual J.P. Morgan Healthcare Conference on Thursday, January 15, 2026, at 9:45 a.m. Pacific Time. About Veracyte Veracyte (Nasdaq: VCYT) is a global diagnostics company whose vision is to transform cancer care for patients all over the world. We empower clinicians with the high-value insights they need to guide and assure patients at piv ...

Core Insights - Veracyte (VCYT) is experiencing significant growth in its Afirma business line and the Decipher franchise, although macroeconomic challenges pose risks to its operations [1][11]. Financial Performance - The company has a market capitalization of $3.41 billion and an earnings yield of 3.8%, outperforming the industry's -2.6% yield [2]. - Veracyte has consistently exceeded earnings estimates over the past four quarters, with an average surprise of 45.1% [2]. Business Highlights - The Afirma solution, including the Afirma GSC and Afirma Xpression Atlas, is effectively addressing thyroid nodule diagnosis, with a 13% volume growth in Q3 2025 driven by new account wins and increased utilization [3][4][9]. - The Decipher franchise has expanded into bladder cancer, with the Decipher Bladder test being the first genomic test covered by Medicare, contributing to a total of approximately 26,700 tests performed in Q3 2025, marking 14 consecutive quarters of over 25% year-over-year volume growth [5][6][9]. - Veracyte ended Q3 2025 with cash and cash equivalents of $366 million and no debt, indicating a strong liquidity position [7][10]. Cost and Economic Challenges - The company faces macroeconomic challenges, including rising interest rates and inflation, which have led to an 11.6% year-over-year increase in total cost of revenues, with selling and marketing expenses rising by 8.1% to $24.5 million [11].

Market Overview - U.S. stock futures showed mixed results, with Dow futures decreasing approximately 0.1% on Monday [1] Company-Specific Movements - Meihua International Medical Technologies Co., Ltd. (NASDAQ:MHUA) announced its delisting from Nasdaq, leading to a significant pre-market decline of 32.9%, bringing shares down to $9.41 [1] - SMX (Security Matters) Public Limited Company (NASDAQ:SMX) shares fell 17.2% to $275.00 after a substantial increase of 135% on the previous Friday [3] - Gulf Resources, Inc. (NASDAQ:GURE) saw a decline of 16.1% to $6.87 following a 4% drop on Friday [3] - Wheeler Real Estate Investment Trust, Inc. (NASDAQ:WHLR) shares decreased by 16.1% to $5.35 after a notable surge of 98% on Friday [3] - Fly-E Group, Inc. (NASDAQ:FLYE) experienced a 14.4% drop to $7.08 after receiving a delinquency notice from Nasdaq regarding a delayed Form 10-Q [3] - Ecarx Holdings Inc. (NASDAQ:ECX) shares fell 9.1% to $1.91 after an 8% gain on Friday [3] - Arteris Inc (NASDAQ:AIP) saw a decline of 7.1% to $16.30 in pre-market trading [3] - Veracyte Inc (NASDAQ:VCYT) shares decreased by 5.7% to $42.06 after a 6% decline on Friday [3] - Chagee Holdings Ltd (NASDAQ:CHA) shares fell 4.6% to $13.91 in pre-market trading [3] - PureTech Health PLC (NASDAQ:PRTC) experienced a 4.2% decline to $17.30, despite announcing a successful end-of-Phase 2 meeting with the FDA for Deupirfenidone (LYT-100) in Idiopathic Pulmonary Fibrosis [3] - PepGen Inc (NASDAQ:PEPG) shares declined by 3.9% to $5.23 in pre-market trading [3]

Market Overview - U.S. stock futures showed mixed results, with Dow futures decreasing approximately 0.1% on Monday [1] Company-Specific Movements - Meihua International Medical Technologies Co., Ltd. (NASDAQ:MHUA) announced its delisting from Nasdaq, leading to a significant pre-market decline of 32.9%, bringing shares down to $9.41 [1] - SMX (Security Matters) Public Limited Company (NASDAQ:SMX) shares fell 17.2% to $275.00 after a substantial increase of 135% on the previous Friday [3] - Gulf Resources, Inc. (NASDAQ:GURE) saw a decline of 16.1% to $6.87 following a 4% drop on Friday [3] - Wheeler Real Estate Investment Trust, Inc. (NASDAQ:WHLR) shares decreased by 16.1% to $5.35 after surging 98% on Friday [3] - Fly-E Group, Inc. (NASDAQ:FLYE) experienced a 14.4% drop to $7.08 after receiving a delinquency notice from Nasdaq regarding a delayed Form 10-Q [3] - Ecarx Holdings Inc. (NASDAQ:ECX) shares fell 9.1% to $1.91 after an 8% gain on Friday [3] - Arteris Inc (NASDAQ:AIP) saw a decline of 7.1% to $16.30 in pre-market trading [3] - Veracyte Inc (NASDAQ:VCYT) shares decreased by 5.7% to $42.06 after a 6% decline on Friday [3] - Chagee Holdings Ltd (NASDAQ:CHA) shares fell 4.6% to $13.91 in pre-market trading [3] - PureTech Health PLC (NASDAQ:PRTC) declined 4.2% to $17.30 despite announcing a successful end-of-Phase 2 meeting with the FDA for Deupirfenidone (LYT-100) in Idiopathic Pulmonary Fibrosis [3] - PepGen Inc (NASDAQ:PEPG) shares decreased by 3.9% to $5.23 in pre-market trading [3]

Core Insights - Zacks Premium offers tools for investors to enhance their stock market strategies, including daily updates on Zacks Rank and Industry Rank, research reports, and stock screens [1][2] Zacks Style Scores - Zacks Style Scores are indicators that rate stocks based on value, growth, and momentum characteristics, helping investors identify stocks likely to outperform the market in the next 30 days [2][3] - Each stock is rated from A to F, with A indicating the highest potential for outperformance [3] Value Score - The Value Style Score focuses on identifying undervalued stocks using financial ratios such as P/E, PEG, and Price/Sales [3] Growth Score - The Growth Style Score assesses a company's financial health and future outlook, analyzing projected and historical earnings, sales, and cash flow [4] Momentum Score - The Momentum Style Score evaluates stocks based on price trends and earnings estimate changes, aiding investors in timing their purchases [5] VGM Score - The VGM Score combines all three Style Scores, providing a comprehensive indicator for investors seeking attractive value, growth, and momentum [6] Zacks Rank - The Zacks Rank is a proprietary model that uses earnings estimate revisions to help investors build successful portfolios, with 1 (Strong Buy) stocks achieving an average annual return of +23.93% since 1988 [7][10] - Stocks with a Zacks Rank of 1 or 2 and Style Scores of A or B are recommended for the highest probability of success [9] Company Spotlight: Veracyte (VCYT) - Veracyte is a diagnostics company specializing in cancer detection, offering advanced genomic tests for various cancers [11] - VCYT holds a 1 (Strong Buy) Zacks Rank and a VGM Score of B, with a Growth Style Score of B indicating a projected year-over-year earnings growth of 38.7% for the current fiscal year [12] - The Zacks Consensus Estimate for VCYT's earnings has increased by $0.23 to $1.65 per share, with an average earnings surprise of +45.1% [12][13]

Veracyte FY Conference Summary Company Overview - **Company**: Veracyte (NasdaqGM:VCYT) - **Industry**: Medtech and Diagnostics Key Financial Highlights - **Q3 Revenue**: Over $131 million, a growth of 14% year-over-year [4] - **Testing Business Growth**: Grew by 17%, with Decipher achieving over 25% growth for 14 consecutive quarters [4] - **Afirma Growth**: Volume increased by 13%, driven by new accounts and deeper penetration into existing accounts [4] - **Adjusted EBITDA**: Reached 30% for the quarter, exceeding expectations, with a forecast to finish the year over 25% [5] Decipher Product Insights - **Market Penetration**: Estimated at 40%, indicating room for growth [7] - **Durability of Growth**: Anticipated demand increase due to the recent launch of the metastatic indication and ongoing clinical trials [8][10] - **Physician Ordering Dynamics**: Changes in how tests are ordered, with a focus on building trust and integrating test ordering into clinical workflows [11][12] NCCN Guidelines Impact - **Guideline Inclusion**: The inclusion of Decipher in NCCN guidelines has provided a tailwind for growth, although isolating the impact from other factors is challenging [14] Digital Pathology and Competitive Landscape - **Digital Pathology Positioning**: Emphasized as complementary to existing tests, with a focus on avoiding confusion among clinicians [16] - **Discordance with Competitors**: Noted a 30% discordance rate between Decipher and a competing test, highlighting Decipher's validation and reliability [18][19] Future Product Developments - **V2 Transcriptome Transition**: Aiming for full transition by the end of the year, expected to enhance efficiency and reduce test failures [29][30] - **Prosigna LDT Launch**: Planned for mid-2026, with a focus on building a commercial team and engaging key opinion leaders [42][43] Market Strategy and Growth Drivers - **Growth Drivers**: Focus on Afirma, Decipher, Prosigna, MRD, and IBD, with a balanced approach to investment and growth [62] - **Market Penetration Goals**: Targeting 80% penetration in the market, currently at 65% [28] Capital Allocation and M&A Strategy - **Cash Position**: Expected to be close to $400 million with no debt, allowing for strategic investments and potential M&A opportunities [70] - **M&A Focus**: Prioritizing investments in core business areas before considering acquisitions [71] Conclusion - Veracyte is positioned for continued growth with strong financial performance, innovative product offerings, and a strategic focus on market penetration and operational efficiency. The company is actively engaging in expanding its product portfolio while maintaining a disciplined approach to capital allocation and investment in growth drivers.

Summary of Veracyte Conference Call Company Overview - **Company**: Veracyte - **Industry**: Life Sciences, specifically focused on molecular diagnostics for cancer Key Points Financial Performance - **Revenue Growth**: Total company revenue grew by 14% year-over-year in Q3 [2][3] - **Testing Business Growth**: Adjusted for a portfolio decision, the testing business grew by 18%, driven by Decipher and Afirma tests [3] - **Decipher Test Performance**: Decipher test volume grew by 26%, marking the 14th consecutive quarter of over 25% growth [3] - **Afirma Test Performance**: Afirma test volume grew by 13%, marking the 13th consecutive quarter of growth [3] - **Adjusted EBITDA Margin**: Achieved an adjusted EBITDA margin of 30%, exceeding the previously anticipated 25% [4] Product Pipeline and Future Growth - **Upcoming Products**: - Launch of an MRD test for muscle-invasive bladder cancer in the first half of 2026 [6][7] - Prosigna test to be launched as a lab-developed test (LDT) in the US, targeting 225,000 patients annually [7] - **International Strategy**: Advancing international strategy with several tests being developed for launch outside the US [7] - **Updated Transcriptome**: Transition to a new generation sequencing instrument for Afirma, expected to reduce costs and improve efficiency [9] Market Position and Competitive Landscape - **Market Penetration**: Veracyte has penetrated approximately 25% of the addressable prostate cancer market, with 75% still available for growth [11][12] - **Clinical Guidelines**: The company has achieved level one NCCN guidelines for intermediate and high-risk patients, which is expected to drive further adoption [12][25] - **Evidence-Driven Approach**: Over 240 publications support the Decipher test, enhancing its credibility and adoption among clinicians [12][27] Sales and Marketing Strategy - **Sales Team Productivity**: The sales team has shown strong productivity, with 55 sales reps and a focus on optimizing territory assignments [35][38] - **Coverage Expansion**: Currently covering 200 million lives, with expectations to increase to 250-275 million in five years, potentially improving ASP by 300-500 basis points [21] Regulatory and Reimbursement Considerations - **PAMA Analysis**: Current reimbursement rates are stable, with no immediate changes expected from PAMA until 2028 [23] - **IVD Development**: Developing a PCR-based test for Decipher to launch in Europe, leveraging existing commercial teams [42] Competitive Dynamics - **No Pricing Pressure**: The company does not currently face bundling or pricing pressure from competitors [39] Conclusion - Veracyte is positioned for continued growth with strong financial performance, a robust product pipeline, and a strategic focus on evidence-based medicine and market penetration. The company is optimistic about future launches and expanding its market share in the molecular diagnostics space.

Veracyte Conference Call Summary Company Overview - **Company**: Veracyte (NasdaqGM:VCYT) - **Industry**: Genomic diagnostics, focusing on cancer diagnostics, particularly thyroid and prostate cancers [3][4] Core Points and Arguments - **Growth and Financial Performance**: - Veracyte is on track to double revenues over the next four years, with EBITDA margins expected to exceed 25% this year [4][5] - Decipher has shown over 25% volume growth for 14 consecutive quarters, while Afirma has experienced year-over-year growth for 13 consecutive quarters [6][9] - The company is ahead of its growth plan, driven by strong performance in Decipher and Afirma [6][10] - **Market Penetration and Opportunities**: - Decipher currently represents about 25% of the overall addressable market, indicating significant room for growth [19] - The addition of new indications, such as metastatic cancer, is expected to expand the patient base by an additional 30,000 patients [20] - Afirma has a market share of approximately 52%, with opportunities for further share gains and market penetration [38] - **Product Pipeline**: - Upcoming products include Prosigna and MRD (Minimal Residual Disease) tests, with MRD expected to launch in muscle-invasive bladder cancer in the first half of next year [41][42] - The company plans to leverage its existing infrastructure for new product launches, focusing on data-driven insights to enhance adoption [46][50] - **Digital Pathology**: - Digital pathology is viewed as complementary to Decipher, with the latter being the gold standard in prostate cancer diagnostics [28][29] - Veracyte is actively supporting digital pathology research, which may enhance its offerings in the future [29][33] Additional Important Insights - **Strategic Focus**: - The company emphasizes a balanced approach to growth, ensuring that new product launches do not compromise profitability [5][16] - Evidence generation is crucial for driving adoption and reimbursement for new tests [19][24] - **Market Dynamics**: - The competitive landscape includes established players like Natera, but Veracyte believes its scientific differentiation will fuel growth [51] - The company is focused on completing the care continuum by offering tests that assist patients throughout their cancer journey [50] - **Prosigna Launch Strategy**: - The launch of Prosigna is contingent on strong data from ongoing studies, with a focus on KOL engagement rather than immediate volume [54][55] - The company aims for a "no regrets" launch, prioritizing optimal data and reimbursement assessments [54] This summary encapsulates the key points discussed during the Veracyte conference call, highlighting the company's growth trajectory, product pipeline, and strategic focus within the genomic diagnostics industry.

Core Insights - Veracyte, Inc. (VCYT) reported a significant increase in adjusted earnings for Q3 2025, reaching 51 cents per share, a 54.5% improvement from the previous year, and exceeding the Zacks Consensus Estimate by 59.4% [1][7] - The company's revenues grew by 13.8% year over year to $131.9 million, surpassing the Zacks Consensus Estimate by 5.5% [2][7] - Following the earnings announcement, VCYT's share price increased by 27.5% [2] Revenue Performance - Testing revenues accounted for $127.8 million, reflecting a 17% year-over-year increase, driven by Decipher and Afirma revenue growth of 26% and 7%, respectively [3] - Product revenues rose by 4% year over year to $3.3 million, while biopharmaceutical and other revenues decreased by 74.2% to $0.8 million [3] Cost and Margins - Total cost of revenues increased by 11.6% year over year to $37.9 million, while gross profit rose by 14.7% to $94 million, leading to a gross margin expansion of 56 basis points to 71.3% [4] - Adjusted operating margin improved by 612 basis points year over year to 19.9% [4] Cash and Capital Structure - At the end of Q3 2025, Veracyte had cash and cash equivalents of $315.6 million, up from $219.5 million at the end of Q2 [5] - Cumulative net cash from operating activities increased to $83.7 million compared to $50.6 million a year ago [5] Guidance Updates - Veracyte raised its full-year 2025 testing revenue guidance to a range of $484-$487 million, indicating a year-over-year growth of 17% to 18% [6] - The total revenue guidance for 2025 was also raised to $506-$510 million, implying a 14% year-over-year growth [8] - Adjusted EBITDA as a percentage of revenues is now expected to exceed 25%, up from the previous guidance of 23.5% [9] Notable Developments - The company launched Afirma v2 transcriptome to enhance the efficiency of its testing business and completed enrollment for the NIGHTINGALE clinical utility trial for the Percepta Nasal Swab test [11]