Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2022 Financial Results SHANGHAI, March 23, 2023 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the fourth quarter and fiscal year ended December 31, 2022. Fourth Quarter 2022 Highlights · Net revenues were RMB4.1 billion (US$601.4 millio ...

111, Inc. (NASDAQ:YI) Q3 2022 Earnings Conference Call December 1, 2022 7:30 AM ET Company Participants Gang Yu - Co-Founder and Executive Chairman Junling Liu - Co-Founder, Chairman and Chief Executive Officer Luke Chen - Chief Financial Officer, Major Subsidiary Harvey Wang - Chief Operating Officer Monica Mu - Investor Relations Director Conference Call Participants Zoe Bian - Citi Operator Hello, everyone, and thank you for joining 111's Conference Call today. On the call today from the company are Dr. ...

Third Quarter 2022 Key Results & Management Commentary Q3 2022 revenue was flat at RMB 3.35 billion due to lockdowns, but gross profit grew 21.6% and Non-GAAP loss narrowed[1](index=1&type=chunk) - CEO Junling Liu stated that business was negatively impacted by COVID-19 lockdowns in various cities and provinces during the quarter[2](index=2&type=chunk) - The company achieved **positive operating cash flow** and overall cash flow for the quarter[2](index=2&type=chunk) Q3 2022 Key Financial Metrics | Metric | Q3 2022 | YoY Change | | :--- | :--- | :--- | | Net Revenues | RMB 3.35 billion | +0.1% | | Gross Segment Profit | - | +21.6% | | Total Operating Expenses as % of Net Revenues | 8.4% | from 10.2% | | Non-GAAP Loss from Operations as % of Net Revenues | 1.5% | from 4.1% | Segment Margin Improvement | Segment | Q3 2022 Margin (%) | Q3 2021 Margin (%) | | :--- | :--- | :--- | | Overall Gross Segment Margin | 6.0% | 5.0% | | B2B Segment Margin | 5.5% | 4.4% | | B2C Segment Margin | 22.4% | 19.7% | [Detailed Financial Performance](index=2&type=section&id=Third%20Quarter%202022%20Financial%20Results) Q3 2022 financial performance details flat revenue, B2B growth, and significant expense reductions narrowing losses [Revenue and Segment Performance](index=2&type=section&id=Revenue%20and%20Segment%20Performance) Q3 2022 segment performance details B2B revenue growth and margin improvement, contrasting with B2C decline Q3 2022 Segment Performance | Metric | B2B Segment (RMB thousands) | YoY Change | B2C Segment (RMB thousands) | YoY Change | | :--- | :--- | :--- | :--- | :--- | | Net Revenue | 3,248,917 | +0.8% | 99,798 | -19.7% | | Segment Profit | 179,601 | +26.9% | 22,381 | -8.7% | | Segment Profit % | 5.5% | from 4.4% | 22.4% | from 19.7% | [Operating Costs and Expenses](index=2&type=section&id=Operating%20Costs%20and%20Expenses) Q3 2022 operating expenses show significant year-over-year reductions across all major categories, enhancing efficiency Q3 2022 Operating Expense Breakdown (YoY) | Expense Category | Amount (RMB million) | YoY Change | As % of Net Revenue | | :--- | :--- | :--- | :--- | | Fulfillment | 100.2 | -0.4% | 2.99% (from 3.01%) | | Selling & Marketing | 107.8 | -18.2% | 3.2% (from 3.9%) | | General & Administrative | 46.1 | -13.1% | 1.4% (from 1.6%) | | Technology | 29.5 | -47.3% | 0.9% (from 1.7%) | [Profitability and Cash Position](index=3&type=section&id=Profitability%20and%20Cash%20Position) Q3 2022 profitability details significant reductions in operating and net losses, alongside a strong cash position Q3 2022 Profitability Metrics (vs. Q3 2021) | Metric | Q3 2022 (RMB million) | Q3 2021 (RMB million) | | :--- | :--- | :--- | | Loss from Operations | (80.7) | (175.4) | | Non-GAAP Loss from Operations | (48.7) | (135.9) | | Net Loss | (86.2) | (165.8) | | Non-GAAP Net Loss | (54.3) | (126.3) | - As of September 30, 2022, the company held **RMB 865.9 million (US$121.7 million)** in cash, cash equivalents, restricted cash, and short-term investments[9](index=9&type=chunk) [Conference Call Information](index=3&type=section&id=Conference%20Call) The company will host an earnings conference call on December 1, 2022, at 7:30 AM U.S. Eastern Time, with registration and webcast details - The earnings conference call is scheduled for **7:30 AM U.S. Eastern Time** on Thursday, December 1, 2022 (8:30 PM Beijing Time)[10](index=10&type=chunk) - Participants must pre-register online for dial-in information, with a live and archived webcast also available[11](index=11&type=chunk) [Notes on Financial Reporting](index=4&type=section&id=Use%20of%20Non-GAAP%20Financial%20Measures) This section explains the company's use of non-GAAP financial measures and includes a forward-looking statements disclaimer [Use of Non-GAAP Financial Measures](index=4&type=section&id=Use%20of%20Non-GAAP%20Financial%20Measures) The company utilizes non-GAAP measures, excluding share-based compensation, for clearer core operating performance insights - The company uses non-GAAP measures, including non-GAAP loss from operations and non-GAAP net loss, to supplement its U.S. GAAP financial results[14](index=14&type=chunk) - These non-GAAP measures primarily exclude **share-based compensation expenses**, which management believes helps identify underlying business trends and provides a better basis for comparing performance[15](index=15&type=chunk) - The company acknowledges the limitations of non-GAAP measures and provides a reconciliation to comparable U.S. GAAP measures[17](index=17&type=chunk)[18](index=18&type=chunk) [Forward-Looking Statements](index=5&type=section&id=Forward-Looking%20Statements) This section notes the press release contains forward-looking statements, subject to various known and unknown risks - This press release contains forward-looking statements based on management's current expectations, subject to known and unknown risks, uncertainties, and other factors[20](index=20&type=chunk) [Unaudited Condensed Consolidated Financial Statements](index=7&type=section&id=Unaudited%20Condensed%20Consolidated%20Financial%20Statements) This section presents unaudited financial statements as of September 30, 2022, detailing balance sheet, comprehensive loss, and positive operating cash flow [Consolidated Balance Sheets](index=7&type=section&id=UNAUDITED%20CONDENSED%20CONSOLIDATED%20BALANCE%20SHEETS) This section presents unaudited consolidated balance sheets, highlighting key asset and liability figures as of September 30, 2022 Balance Sheet Highlights (as of Sep 30, 2022 vs. Dec 31, 2021) | Account | Sep 30, 2022 (RMB thousands) | Dec 31, 2021 (RMB thousands) | | :--- | :--- | :--- | | Cash, cash equivalents, restricted cash & short-term investments | 865,946 | 943,228 | | Total Current Assets | 2,791,956 | 2,801,737 | | Total Assets | 3,054,959 | 3,145,833 | | Total Current Liabilities | 2,258,122 | 2,129,978 | | Total Liabilities | 2,373,055 | 2,297,129 | [Consolidated Statements of Comprehensive Loss](index=8&type=section&id=UNAUDITED%20CONDENSED%20CONSOLIDATED%20STATEMENTS%20OF%20COMPREHENSIVE%20LOSS) This section presents unaudited consolidated statements of comprehensive loss, detailing revenue, expenses, and net loss for Q3 2022 Statement of Comprehensive Loss (Q3 2022 vs Q3 2021) | Metric | For the three months ended Sep 30, 2022 (RMB thousands) | For the three months ended Sep 30, 2021 (RMB thousands) | | :--- | :--- | :--- | | Net Revenues | 3,348,715 | 3,346,227 | | Total Operating costs and expenses | (3,429,384) | (3,521,583) | | Loss from operations | (80,669) | (175,356) | | Net Loss | (86,240) | (165,780) | | Net Loss attributable to ordinary shareholders | (96,846) | (252,855) | | Loss per ADS (Basic and diluted) | (1.16) RMB | (3.04) RMB | [Consolidated Statements of Cash Flows](index=9&type=section&id=UNAUDITED%20CONDENSED%20CONSOLIDATED%20STATEMENTS%20OF%20CASH%20FLOWS) This section presents unaudited consolidated statements of cash flows, summarizing operating, investing, and financing activities for Q3 2022 Cash Flow Summary (Q3 2022 vs Q3 2021) | Activity | For the three months ended Sep 30, 2022 (RMB thousands) | For the three months ended Sep 30, 2021 (RMB thousands) | | :--- | :--- | :--- | | Net cash provided by (used in) operating activities | 11,815 | (107,181) | | Net cash provided by (used in) investing activities | 100,460 | (243,454) | | Net cash used in financing activities | (40,755) | (5,307) | | Net increase (decrease) in cash | 78,539 | (355,177) | [Reconciliation of GAAP and Non-GAAP Results](index=10&type=section&id=Unaudited%20Reconciliation%20of%20GAAP%20and%20Non-GAAP%20Results) This section provides a clear reconciliation of GAAP to non-GAAP financial results for Q3 2022, adjusting for share-based compensation Q3 2022 GAAP to Non-GAAP Reconciliation | Metric | GAAP Figure (RMB thousands) | Share-based Compensation (RMB thousands) | Non-GAAP Figure (RMB thousands) | | :--- | :--- | :--- | :--- | | Loss from operations | (80,669) | 31,938 | (48,731) | | Net Loss | (86,240) | 31,938 | (54,302) | | Net Loss attributable to ordinary shareholders | (96,846) | 31,938 | (64,908) | Q3 2022 Loss per ADS Reconciliation | Metric | GAAP Figure (RMB) | Share-based Compensation per ADS (RMB) | Non-GAAP Figure (RMB) | | :--- | :--- | :--- | :--- | | Loss per ADS | (1.16) | 0.38 | (0.78) |

111, Inc. (NASDAQ:YI) Q2 2022 Earnings Conference Call August 25, 2022 7:30 AM ET Company Participants Monica Mu - Investor Relations Director Gang Yu - Co-Founder and Executive Chairman Junling Liu - Co-Founder, Chairman and Chief Executive Officer Luke Chen - Chief Financial Officer, Major Subsidiary Harvey Wangg - Chief Operating Officer Conference Call Participants Xipeng Feng - CICC Zoe Bian - Citi Operator Hello everyone and thank you for joining 111's Conference Call today. On the call today from the ...

Financial Performance - Revenue reached RMB 3037145000 despite difficult circumstances[12, 44] - Gross profit significantly increased to RMB 192 million, a 43% year-over-year increase[12] - B2B segment revenue increased by 13% year-over-year to RMB 2935000000[16, 31] - B2B segment gross profit increased by 55% year-over-year to RMB 169 million[15, 16] - B2C segment revenue decreased by 20% year-over-year to RMB 103 million[31] - Non-GAAP operating loss as a percentage of net revenue decreased by 320 basis points year-over-year to 17%[17] Operational Efficiency - G&A expense as a percentage of net revenue decreased by 25% year-over-year[17] - Operating expense as a percentage of net revenue decreased from 107% in 2021 Q2 to 89% in 2022 Q2 including share-based compensation expenses[35] New Initiatives - 1 Health program connects digitally with over 67 million patients, with a 48% quarter-over-quarter increase in patients[18] - High Margin Product Program saw a 232% year-over-year increase in GMV[20] - Cloud Promotion Platform covered over 7000 pharmacies and 9000 pharmacy managers/pharmacists/salespersons[24]

111, Inc. (NASDAQ:YI) Q1 2022 Earnings Conference Call June 16, 2022 7:30 AM ET Company Participants Monica Mu - Investor Relations Director Junling Liu - Co-Founder, Chairman and Chief Executive Officer Luke Chen - Chief Financial Officer, Major Subsidiary Harvey Wangg - Chief Operating Officer Conference Call Participants Xipeng Feng - CICC Jessie Lu - HSBC Zoe Bian - Citi Operator Good day and thank you for standing by. Welcome to the First Quarter 2022 Earnings Conference Call. At this time all particip ...

111, Inc. (NASDAQ:YI) Q4 2021 Earnings Conference Call March 17, 2022 7:30 AM ET Company Participants Monica Mu - IR Director Junling Liu - Co-Founder, Chairman and Chief Executive Officer Luke Chen - CFO, Major Subsidiary Harvey Wangg - Chief Operating Officer Conference Call Participants Zoe Bian - Citi Xipeng Feng - CICC Kenneth Lau - Cornerstone Investment Marcus Shi - Individual Investor Disclaimer*: This transcript is designed to be used alongside the freely available audio recording on this page. Tim ...