zymeworks JP Morgan 2022 Healthcare Conference Neil Klompas, COO & CFO NYSE: ZYME Zymeworks Inc www.zymeworks.com 2 Legal Disclaimer This presentation includes "forward-looking statements" within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and "forward-looking information" within the meaning of Canadian securities laws, or collectively, forward looking statements. Forward-looking statements include statements that may relate to our plans, objectives, goals, strategies, future ev ...

zymeworks Jefferies London Healthcare Conference Presentation November 18th – 19th Ali Tehrani - President & CEO www.zymeworks.com NYSE: ZYME Undergoing Transformation En Route Towards Commercialization 2023 2024 2025 2026 Biliary Tract BLA Second-Line üFast-to-Market Strategy üSingle-agent, single-arm üUS Accelerated Approval Gastroesophageal sBLA First-Line ü Expand Strategy ü Zani + Chemo ± PD1 Biliary Tract sBLA First-Line ü Expand Strategy ü Zani + Chemo (± PD11) 3 BLAs in Gastrointestinal Cancers in N ...

zymeworks Making Therapies that Make a Difference CORPORATE OVERVIEW NYSE: ZYME 2021 Bloom Burton & Co. Healthcare Investor Conference www.zymeworks.com 2 Legal Disclaimer This presentation includes "forward-looking statements" within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and "forward-looking information" within the meaning of Canadian securities laws, or collectively, forward looking statements. Forward-looking statements include statements that may relate to our plans, o ...