CNCEC(SH:601117) 3 6 Ke·2025-11-10 09:05Core Viewpoint - The research by Zhang Xiaoheng's team at the University of Science and Technology of China introduces a new method for direct deaminative functionalization using N-nitroamines, which is simpler, safer, and more efficient than traditional processes [1][2][3]. Summary by Sections Research Significance - The study has the potential to revolutionize the field of organic chemistry, particularly in the synthesis of aromatic amines, which are foundational in pharmaceuticals, dyes, pesticides, and electronic materials [3][4]. - The method could significantly impact industrial applications, potentially leading to Nobel Prize recognition due to its groundbreaking nature [3]. Methodology - Traditional methods for processing aromatic amines have been dangerous, expensive, and inefficient, often producing hazardous byproducts [4][10]. - The new approach activates amines into a more stable N-nitroamine state, improving safety and allowing for easier subsequent reactions [10][11]. - The reaction mechanism involves several steps, including the transformation of amines into N-nitroamines, followed by proton migration and dehydration, ultimately leading to the formation of new chemical bonds [10][11]. Industrial Applications - The new method enhances safety and efficiency, allowing for a broader range of reactants and reducing the need for metal catalysts, which are often problematic in traditional methods [11][13]. - The process can be conducted in a single pot, eliminating the need for purification between reactions, which is a significant advancement for industrial scalability [15]. - This innovation could lead to substantial cost savings and reduced environmental impact in the production of agricultural chemicals and pharmaceuticals [16][18]. Impact on Daily Life - The improved deaminative process could lower production costs for essential agricultural products, such as herbicides, thereby reducing pollution and enhancing food security [16]. - In the pharmaceutical sector, the method could significantly decrease the production costs of complex drugs, such as Imatinib Mesylate, making them more accessible to patients [18][20]. - The technology has the potential to enhance the efficiency of drug development, allowing for faster iterations and potentially saving more lives [20]. Historical Context - N-nitroamines have been known since 1893, but their potential was largely unexplored until now, highlighting the innovative nature of Zhang's team's work [21].