港股医药IPO热潮：从“讲故事”到“拼数据”，严把质量关

Core Viewpoint - The Hong Kong stock market for biopharmaceutical IPOs has seen a significant increase in activity, with multiple companies successfully listing and others submitting applications, indicating a strong market outlook for biotech firms in the region [1][3]. Group 1: Market Performance - The biopharmaceutical sector in Hong Kong has experienced a surge in IPO activity, with 28 companies successfully listed in the first three quarters of the year, a 100% increase year-on-year, with over 60% being innovative drug companies [1]. - The IPO of Baoji Pharmaceutical on December 10 saw a first-day increase of 129%, closing at 69 HKD per share, leading to a market capitalization of 22.493 billion HKD [1]. - The Hong Kong stock market is currently the leading global venue for IPO financing in the healthcare sector, with expectations that it will remain the primary listing choice for Chinese biotech companies through 2026 [1][3]. Group 2: Company Developments - Companies like Junshi Biosciences and Gaohong Pharmaceutical have submitted IPO applications despite not having products approved for market, while He Mei Pharmaceutical and Shiyao Innovation have entered the commercialization phase [3]. - Junshi Biosciences is focused on innovative cell therapies for solid tumors, with its core product expected to be the first TIL therapy approved in China [3][4]. - He Mei Pharmaceutical is targeting autoimmune diseases, with its drug Mufemilast expected to receive NDA approval in September 2025 for treating moderate to severe plaque psoriasis [5]. Group 3: Financial Insights - Gaohong Pharmaceutical has entered a collaboration with Biohaven Ltd., receiving 10 million USD in cash and shares, with potential milestone payments totaling up to 2 billion USD based on product development and sales [6]. - Despite advancements in commercialization, both He Mei Pharmaceutical and Gaohong Pharmaceutical reported significant losses, with He Mei showing a pre-tax loss of 73 million CNY and Gaohong reporting a loss of 190 million CNY for the first half of 2025 [6]. Group 4: Industry Trends - The trend of "A+H" dual listing is becoming more common among biopharmaceutical companies, as seen with Shiyao Innovation's strategy to tap into multiple capital markets [7][8]. - The competitive landscape for TIL therapies is intensifying, with the global market expected to grow from 104 million USD in 2024 to 1.692 billion USD by 2030, and the Chinese market projected to reach 200 million USD by 2030 [4]. - The overall sentiment in the Hong Kong biopharmaceutical sector remains cautious, with companies focusing on pipeline quality and financial management to navigate the current market challenges [9].