Investment Rating - The report maintains an "OUTPERFORM" rating for Sichuan Kelun-Biotech with a target price of HK$519.20 [2][3]. Core Views - The company is expected to see robust growth driven by domestic commercialization and global collaborations, particularly in the ADC (Antibody-Drug Conjugate) sector [7][8]. - The drug Sac-TMT is anticipated to become a significant partner to Keytruda, with potential peak sales reaching USD 15-20 billion [8][13]. - The revenue forecasts for FY25-27 have been revised upwards, with expected revenues of RMB 20.6 billion, RMB 28.0 billion, and RMB 48.3 billion respectively [3][7]. Summary by Sections Financial Projections - Revenue for FY24 is projected at RMB 1.933 billion, increasing to RMB 2.056 billion in FY25, RMB 2.798 billion in FY26, and RMB 4.833 billion in FY27, reflecting growth rates of 25%, 6%, 36%, and 73% respectively [2][3]. - Net profit is expected to improve from a loss of RMB 267 million in FY24 to a profit of RMB 879 million by FY27 [2][3]. Product Pipeline and Market Position - The company has commercialized three products in China and has one product awaiting NDA approval, with over ten products in early clinical stages [7][8]. - The ADC platform is positioned as a leader in the domestic biopharmaceutical sector, with significant collaborations with Merck in the ADC field [7][8]. Clinical Development and Global Expansion - Sac-TMT has initiated 14 overseas clinical trials covering various cancers, with a potential patient population of 200,000 to 300,000 [8][20]. - The drug is expected to show strong sales growth in conjunction with Keytruda, particularly in lung cancer and breast cancer indications [8][13]. Competitive Landscape - Sac-TMT is positioned to become a best-in-class TROP2 ADC, with ongoing clinical trials expected to validate its efficacy against existing therapies [13][35]. - The report highlights the competitive advantages of Sac-TMT over other ADCs in the market, particularly in addressing unmet needs in NSCLC and breast cancer [24][35].
科伦博泰生物-B（06990）：Sac-TMT：有望成为药王Keytruda的黄金拍档