AKESO(HK:09926) Guoxin Securities·2025-08-29 14:07Investment Rating - The report maintains an "Outperform" rating for the company [6][4]. Core Insights - The company's core products have seen rapid sales growth after being included in the medical insurance directory, with revenue for the first half of 2025 reaching 1.41 billion yuan, a 37.8% increase year-on-year, and commercial sales revenue of 1.40 billion yuan, up 49.2% [1][9]. - The company reported a loss of 588 million yuan for the first half of 2025, widening from a loss of 249 million yuan in the same period last year, primarily due to investment losses, increased R&D expenses, and stock incentive costs [1][9]. - The company has a strong cash reserve of approximately 7.14 billion yuan as of mid-2025, indicating a solid financial position [1][9]. Summary by Sections Clinical Development - The drug "依沃西" has achieved significant overall survival (OS) benefits in the HARMONi-A trial and has initiated 13 Phase III clinical trials, with 4 trials already showing positive results [2][15]. - Two indications for "依沃西" have been approved in China, and it is also being tested in various cancers, including colorectal and pancreatic cancers [2][15]. Pipeline and Strategy - The company is upgrading its pipeline with a focus on IO2.0 and ADC strategies, with several innovative candidates in clinical trials, including AK137 (CD73/LAG3 dual antibody) and AK138D1 (HER3 ADC) [3][17]. - The company aims to provide new treatment options through internal pipeline combinations [3][17]. Financial Forecast - The report forecasts revenues of 3.30 billion yuan, 5.20 billion yuan, and 7.90 billion yuan for 2025, 2026, and 2027, respectively, with net profits projected at 29 million yuan, 730 million yuan, and 1.79 billion yuan for the same years [4][18].