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三生制药(01530):将和辉瑞密切讨论III期方案,抗体平台在研新分子值得关注

Investment Rating - The report maintains an "Outperform" rating for the company with a target price of HKD 43.70, based on a current price of HKD 29.96 [2][23]. Core Insights - The company is engaging in discussions with Pfizer regarding the Phase III trial design for SSGJ-707, a PD-1/VEGF antibody, which is a significant development in its pipeline [1][4]. - The company reported a revenue of RMB 4.36 billion for the first half of 2025, reflecting a slight decline of 0.8% year-on-year, with various product sales showing mixed performance [3][15]. - The company is advancing multiple bispecific and trispecific antibody candidates, which are expected to enhance its product offerings and market position [5][18][20]. Financial Performance - Revenue projections for 2025-2027 are RMB 18.63 billion, RMB 10.90 billion, and RMB 12.80 billion, with net profit estimates of RMB 8.92 billion, RMB 2.49 billion, and RMB 3.02 billion respectively [9][23]. - The gross profit margin is expected to remain strong, with estimates of 92.5% in 2025 and around 87% in subsequent years [9][13]. - The company has seen a significant increase in R&D expenses, which rose by 15% to RMB 550 million, indicating a commitment to innovation [3][15]. Product Development and Pipeline - The company has several key products in development, including SSGJ-707, which has received a global licensing agreement with Pfizer, and other bispecific antibodies like 705 and 706, which are in various stages of clinical trials [4][18][19]. - SSS59, a trispecific antibody, is the first of its kind to enter clinical trials, showing promising preclinical results [20]. - Upcoming catalysts include NDA submissions for several products and potential data readouts for bispecific and trispecific candidates [22][23].