Core Viewpoint - The recent high-value transaction involving the innovative drug SSGJ-707 by 3SBio and Pfizer highlights the growing trend of Chinese biopharmaceutical companies expanding into international markets, despite challenges in the global pharmaceutical environment [2][4]. Group 1: Transaction Details - Pfizer has made a non-refundable upfront payment of $1.25 billion (approximately 9 billion RMB) for the rights to SSGJ-707 outside of China, with potential milestone payments totaling up to $4.8 billion (approximately 34.5 billion RMB) and an additional $100 million for equity subscription [2]. - This transaction sets a record for the upfront payment for a Chinese innovative drug going overseas, indicating a significant shift in the landscape of biopharmaceutical transactions [4]. Group 2: Company Background - 3SBio, established in 1993, is a well-established pharmaceutical company that went public on NASDAQ in 2007 and later privatized before listing on the Hong Kong Stock Exchange in 2015 [3]. - The subsidiary involved in the transaction, 3SBio Guojian, was formerly known as CITIC Guojian and is recognized as one of the earliest companies in China to engage in antibody drug research and sales [3]. Group 3: Market Trends - The trend of Chinese innovative drug companies seeking international partnerships has been growing, with a nearly 40% increase in outbound business development (BD) transactions since 2022, projected to reach around 120 deals worth approximately $63 billion in 2024 [6]. - The stock prices of 3SBio and 3SBio Guojian have surged over 200% and 130%, respectively, following the announcement of this transaction, reflecting strong market interest in innovative drug development [4]. Group 4: Strategic Implications - The increasing trend of "going overseas" is reshaping the clinical research strategies of domestic innovative drug companies, with many now considering international transactions as a key part of their development plans [4]. - The shift from a "me too" model to a focus on first-in-class (FIC) drugs is evident, as domestic companies are increasingly competing head-to-head with multinational pharmaceutical firms [4][5].

Investment Rating - The investment rating for the company is "Buy" [7] Core Insights - The company has entered into a significant licensing agreement with Pfizer for the PD-1/VEGF bispecific antibody (SSGJ-707), which includes an upfront payment of $1.25 billion and potential milestone payments totaling up to $4.8 billion [1][2] - The licensing agreement allows the company to retain development and commercialization rights for SSGJ-707 in mainland China, while Pfizer has the option to commercialize the product in China [1] - The company is expected to see a substantial increase in pre-tax profits due to the upfront payment, estimated at approximately $1.175 billion [2] - SSGJ-707 is currently undergoing multiple clinical studies in China, including a Phase III trial for treating PD-L1 positive locally advanced or metastatic non-small cell lung cancer (NSCLC) [3][6] Financial Projections - The company’s projected revenues for 2025, 2026, and 2027 are estimated to be 185.9 billion, 133.7 billion, and 145.9 billion CNY respectively, reflecting a year-on-year growth of 104.1%, -28.1%, and 18.5% [7][9] - The projected net profit attributable to the parent company for the same years is expected to be 95.9 billion, 53.2 billion, and 60.8 billion CNY, with year-on-year growth rates of 358.7%, -44.5%, and 14.2% [7][9] - The earnings per share (EPS) for 2025, 2026, and 2027 are projected to be 4.00, 2.22, and 2.54 CNY respectively, with corresponding price-to-earnings (PE) ratios of 4.7, 8.4, and 7.3 [7][9] Clinical Development - SSGJ-707 has received IND approval from the FDA and is set to initiate clinical studies in the United States [6] - The product is also involved in several Phase II studies in China, targeting various indications including metastatic colorectal cancer and advanced gynecological tumors [10]

Core Viewpoint - The China Securities Hong Kong Biotechnology Theme Index has shown significant growth, with a year-to-date increase of 41.25% [1] Group 1: Index Performance - The China Securities Hong Kong Biotechnology Theme Index reported a value of 1436.15 points, with a monthly increase of 5.87% and a three-month increase of 12.26% [1] - The index is composed of 50 listed companies in Hong Kong involved in biopharmaceuticals, pharmaceuticals, and biotechnology services, reflecting the overall performance of these companies [1] Group 2: Index Composition - The top ten weighted companies in the index are: BeiGene (14.97%), WuXi Biologics (11.09%), Innovent Biologics (10.93%), CanSino Biologics (6.86%), CSPC Pharmaceutical Group (6.41%), China Biologic Products (5.46%), 3SBio (4.21%), Hansoh Pharmaceutical (3.59%), Zai Lab (2.97%), and WuXi AppTec (2.93%) [1] - The index is fully composed of companies listed on the Hong Kong Stock Exchange, with a 100% allocation [1] Group 3: Industry Breakdown - The industry composition of the index shows that biopharmaceuticals account for 53.76%, chemical drugs for 24.57%, pharmaceutical and biotechnology services for 18.50%, and medical devices for 3.18% [2] - The index samples are adjusted biannually, with adjustments occurring on the next trading day after the second Friday of June and December [2]

Core Insights - Chinese innovative pharmaceutical company 3SBio has entered a record-breaking License out agreement with Pfizer, potentially worth up to $60.5 billion (approximately 435 billion RMB) [1] - This transaction sets a new record for the amount of a single product going overseas from a Chinese pharmaceutical company and highlights the strong emergence of Chinese innovative drug companies in the global bispecific antibody market [1] Transaction Details - The agreement grants Pfizer the rights to develop, produce, and commercialize 3SBio's self-developed PD-1/VEGF bispecific antibody SSGJ-707 in global markets outside mainland China [2] - Pfizer will pay an upfront fee of $12.5 billion (approximately 90 billion RMB) and up to $4.8 billion in milestone payments, along with a double-digit percentage tiered revenue share from sales in the licensed regions [2] - All payments are non-refundable and non-offsettable, and Pfizer retains the option to commercialize the product in mainland China [2] Product Advantages - SSGJ-707 is developed based on 3SBio's proprietary CLF2 platform, featuring a common light chain symmetrical design and IgG-like structure, which significantly reduces production costs and enhances efficiency [3] - Clinical data shows promising anti-tumor activity and safety: - Objective response rate (ORR) of 70.8% and disease control rate (DCR) of 100% for PD-L1 positive non-small cell lung cancer (NSCLC) [3] - ORR of 81.3% for squamous NSCLC and 58.3% for non-squamous NSCLC, with DCR at 100% when combined with chemotherapy [3] - Adverse event rates for grade 3 or higher treatment-related adverse events (TRAE) range from 8.9% to 23.5%, significantly lower than similar products [3] Market Outlook - The PD-1/VEGF bispecific antibody market is expected to explode, with Evaluate Pharma predicting a global market size exceeding $80 billion by 2030 [5] - Currently, only Kangfang Biotech's Ivosidenib is on the market, and 3SBio's rapid advancement positions it to seize market opportunities [5] Industry Trends - The total value of License out transactions for Chinese innovative drugs reached $51.9 billion in 2024, a year-on-year increase of 27.4%, accounting for 30% of global similar transactions [6] - In the first quarter of 2025, Chinese companies completed 41 overseas transactions totaling over $36.9 billion, with a growing proportion of "heavyweight transactions" [6] - This collaboration further confirms the transition of Chinese innovative drug companies from "followers" to "leaders" in the global market [6] Industry Outlook - This transaction not only brings substantial cash flow to 3SBio but also highlights the maturity of Chinese pharmaceutical companies in target selection, clinical design, and international collaboration [7] - As more original Chinese drugs enter the global market, the "two-way rush" between multinational and Chinese pharmaceutical companies may become the new norm, accelerating the gathering of global pharmaceutical innovation resources in China [7] Conclusion - The collaboration between 3SBio and Pfizer marks a significant milestone for Chinese innovative drugs going global, transitioning from "Made in China" to "Created in China" [8] - With support from policies, capital, and technological breakthroughs, Chinese pharmaceutical companies are entering a golden era of License out, potentially reshaping the global pharmaceutical market landscape [8]

Group 1 - The company signed an exclusive agreement with Pfizer for the global development, production, and commercialization rights of its PD-1/VEGF bispecific antibody SSGJ-707, excluding mainland China, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion [1] - The agreement also includes a tiered sales revenue sharing based on product sales in the licensed regions, and Pfizer will purchase $100 million worth of common stock in the company upon the agreement's effective date [1] - The company maintains its profit forecast, expecting net profits of 2.328 billion, 2.612 billion, and 2.938 billion yuan for 2025-2027, with corresponding EPS of 0.97, 1.09, and 1.23 yuan per share, resulting in a current PE of 9.3, 8.3, and 7.4 times [1] Group 2 - SSGJ-707 has shown excellent ORR and DCR in the treatment of NSCLC patients, indicating its best-in-class potential, and has received breakthrough therapy designation from the National Medical Products Administration for first-line treatment of PD-L1 positive locally advanced or metastatic NSCLC [2] - The company is advancing clinical research for SSGJ-707 in other areas, including colorectal cancer and gynecological tumors, and has received FDA IND approval [2] - The company’s existing products, such as Tebentafusp, are expected to see growth due to successful negotiations for zero price reduction in 2024 and the addition of new indications, contributing to cash flow [2]

Core Viewpoint - The collaboration between 3SBio and Pfizer for SSGJ-707 marks a significant milestone in the Chinese biopharmaceutical industry, with a total upfront payment of $1.25 billion and potential milestone payments reaching up to $4.8 billion, indicating strong market confidence in the drug's potential [1][2]. Group 1: Licensing Agreement and Financial Implications - 3SBio has granted Pfizer global development, production, and commercialization rights for SSGJ-707 outside of mainland China while retaining rights for mainland China and granting Pfizer commercialization options [1]. - The agreement includes a non-refundable upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion based on development, regulatory approvals, and sales [1]. - Additionally, 3SBio will receive a tiered sales royalty based on product sales in the licensed regions [1]. Group 2: Clinical Development and Pipeline - SSGJ-707 has shown significant anti-tumor activity and good safety in Phase II clinical trials, positioning it as a potential best-in-class therapy [2]. - The drug is currently undergoing four Phase II clinical studies in China, targeting various cancers including PD-L1 positive non-small cell lung cancer (NSCLC) and advanced gynecological tumors [2]. - Future catalysts for SSGJ-707 include Pfizer's overseas clinical progress, advancements in domestic Phase III trials, and data releases from major conferences like ASCO [2]. Group 3: Existing Product Portfolio and Growth Potential - 3SBio's existing core products are mature and leading in their respective segments, with expected stable growth [2]. - Key products include Terbinafine, which is the company's top-selling product, and Erythropoietin, which has new indications covered by insurance, opening up significant market potential [2]. - The company is also focusing on oral paclitaxel and other promising candidates in its pipeline, indicating a robust growth strategy [3]. Group 4: Financial Forecast and Market Valuation - The projected peak sales for SSGJ-707 are estimated at $8.5 billion, with a 10% sales royalty contributing to a market value of approximately 35 billion [4]. - The domestic peak sales are estimated at $5 billion, contributing an additional 15 billion in market value [4]. - The total target market capitalization is around 80 billion, with significant adjustments to net profit forecasts for 2025-2027, reflecting strong growth expectations [4].

Group 1 - The company signed a licensing agreement with Pfizer for the PD1×VEGF dual antibody SSGJ707, granting Pfizer global rights (excluding mainland China) for development, production, and commercialization, with an upfront payment of $1.25 billion and potential milestone payments of $4.8 billion [1] - The $1.25 billion upfront payment sets a record for Chinese innovative drug licensing out, indicating strong market validation for the PD1×VEGF dual antibody sector [1] - The clinical development speed of SSGJ707 in the U.S. is expected to be rapid due to Pfizer's robust clinical development platform and commercialization system [1] Group 2 - The company has four mid-to-late stage clinical assets (IL17, IL1β, IL4R, IL5 monoclonal antibodies), each projected to generate over $1 billion in revenue, with IL17 expected to commercialize in 2025 [2] - The company forecasts revenue growth from 2025 to 2027, estimating revenues of 10.201 billion, 11.494 billion, and 13.153 billion yuan, with year-on-year growth rates of 12.0%, 12.7%, and 14.4% respectively [2] - The company anticipates net profit growth during the same period, projecting net profits of 2.345 billion, 2.648 billion, and 3.027 billion yuan, with growth rates of 12.2%, 12.9%, and 14.3% respectively [2]

Group 1 - The core point of the article is the licensing agreement between 3SBio and Pfizer for the development and commercialization of SSGJ-707, a bispecific antibody targeting PD-1 and VEGF, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion [1][2] - SSGJ-707 has shown promising clinical results in non-small cell lung cancer (NSCLC) with high objective response rates (ORR) and disease control rates (DCR), indicating its best-in-class potential [2] - The drug has received breakthrough therapy designation from the National Medical Products Administration (NMPA) in China and IND approval from the FDA, with ongoing clinical studies for other cancers [2] Group 2 - The company expects steady growth in its core products, including Tezspire and Mandi, in 2024, along with expansion in indications and formulations [3] - The company has established four new collaborations in 2024, enhancing its commercial footprint and product portfolio [3] - Revenue forecasts for the company have been adjusted upwards, with projected total revenues of 18.244 billion, 12.752 billion, and 14.731 billion yuan for 2025-2027, and corresponding net profits of 8.575 billion, 3.413 billion, and 4.102 billion yuan [3]

Investment Rating - The investment rating for the company is "Buy" (maintained) [2][9] Core Views - The company has signed a licensing agreement with Pfizer for the PD1×VEGF dual antibody SSGJ707, receiving an upfront payment of $1.25 billion, which is the largest for a Chinese innovative drug license-out, along with potential milestone payments of $4.8 billion and double-digit royalties on net sales [4][6] - The company is expected to achieve revenue growth of 12% to 14% from 2025 to 2027, with projected revenues of 102.01 billion, 114.94 billion, and 131.53 billion yuan respectively [6] - The net profit forecast for the same period is 23.45 billion, 26.48 billion, and 30.27 billion yuan, reflecting a growth rate of 12.2% to 14.3% [6] Summary by Sections Financial Performance - The company is projected to have operating revenues of 7,836 million yuan in 2023, increasing to 10,201 million yuan in 2025, with a year-on-year growth rate of 14% in 2023 and 12% in 2025 [2] - The net profit attributable to the parent company is expected to rise from 1,549 million yuan in 2023 to 2,345 million yuan in 2025, with a significant increase of 35% in 2024 [2] - Earnings per share (EPS) is forecasted to grow from 0.65 yuan in 2023 to 0.98 yuan in 2025 [2] Market Position and Prospects - The PD1×VEGF dual antibody market is expected to grow significantly, with SSGJ707 showing promising clinical data and a strong partnership with Pfizer, which enhances the clinical development speed in the U.S. [6] - The company has a robust pipeline with four mid-to-late stage monoclonal antibodies, including IL17, which is expected to be commercialized in 2025, indicating a strong potential for revenue generation [6] Valuation Metrics - The price-to-earnings (P/E) ratio is projected to decrease from 28.5 in 2023 to 18.9 in 2025, indicating an improving valuation as earnings grow [2] - The price-to-book (P/B) ratio is expected to decline from 3.2 in 2023 to 2.4 in 2025, reflecting a more attractive valuation over time [2]

Investment Rating - The investment rating for the company is "Buy" (maintained) [2][9] Core Views - The company has signed a licensing agreement with Pfizer for the PD1×VEGF dual antibody SSGJ707, receiving an upfront payment of $1.25 billion, which is the largest for a Chinese innovative drug license-out, along with potential milestone payments of $4.8 billion and double-digit royalties on net sales [4][6] - The company is expected to achieve revenue growth of 12% to 14% from 2025 to 2027, with projected revenues of 102.01 billion, 114.94 billion, and 131.53 billion yuan respectively [6] - The company is anticipated to see a significant acceleration in domestic revenue due to multiple late-stage clinical assets, including IL17 monoclonal antibody expected to commercialize in 2025 [6] Summary by Sections Financial Forecasts - Projected operating revenue (in million yuan): 7,836 (2023A), 9,108 (2024A), 10,201 (2025E), 11,494 (2026E), 13,153 (2027E) with growth rates of 14%, 16%, 12%, 13%, and 14% respectively [2] - Expected net profit attributable to shareholders (in million yuan): 1,549 (2023A), 2,090 (2024A), 2,345 (2025E), 2,648 (2026E), 3,027 (2027E) with growth rates of -19%, 35%, 12%, 13%, and 14% respectively [2] - Earnings per share (in yuan): 0.65 (2023A), 0.87 (2024A), 0.98 (2025E), 1.10 (2026E), 1.26 (2027E) [2] Market Position and Development - The PD1×VEGF dual antibody market is validated, with significant clinical results from competitors enhancing the outlook for SSGJ707 [6] - The company’s collaboration with Pfizer is expected to accelerate clinical development in the U.S. due to Pfizer's robust clinical and commercialization capabilities [6] Valuation Metrics - Projected P/E ratios: 28.5 (2023A), 21.2 (2024A), 18.9 (2025E), 16.7 (2026E), 14.6 (2027E) [2] - Projected P/B ratios: 3.2 (2023A), 2.9 (2024A), 2.4 (2025E), 2.0 (2026E), 1.7 (2027E) [2]