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三生制药(01530):收获期迸发对外合作,长期增长显著

Investment Rating - The investment rating for the company is "Buy" and is maintained [6]. Core Insights - In the first half of 2025, the company achieved a net profit attributable to shareholders of 1.358 billion yuan, representing a year-on-year growth of 24.6%. The operating revenue was 4.355 billion yuan, with R&D expenditure of 548 million yuan, up 15% year-on-year. The adjusted non-operating EBITDA was 1.610 billion yuan [2][4]. - The company entered into a significant collaboration with Pfizer, securing a $1.5 billion upfront payment for the PD-1/VEGF dual antibody SSGJ-707, with 13 pipelines nearing harvest in four major therapeutic areas, indicating strong growth momentum [2][4]. - The company has a diversified product matrix through external collaborations, including a partnership for an oral paclitaxel solution and a collaboration for semaglutide injection for weight loss [4]. Financial Performance - The company reported a net profit of 1.358 billion yuan in H1 2025, a 24.6% increase year-on-year, with operating revenue of 4.355 billion yuan and gross profit of 3.716 billion yuan. R&D spending was 548 million yuan, reflecting a 15% increase [4]. - The company’s cash on hand was nearly 8 billion yuan as of June 30, 2025, and its interest-bearing debt decreased by nearly half, resulting in a leverage ratio drop from 19.7% at the end of 2024 to 9.9% [4]. Pipeline and Collaborations - The company has 30 products in its pipeline, with 13 new drugs advancing to clinical phase III or NDA submission stages. Notable products include PD-1/HER2 dual antibody SSGJ-705 and PD-1/PD-L1 dual antibody SSGJ-706, both in phase II clinical trials [4]. - The collaboration with Pfizer is expected to yield up to $4.8 billion in milestone payments and double-digit sales royalties, enhancing the company's global innovation pipeline [4]. Earnings Forecast - The company’s projected net profits for 2025, 2026, and 2027 are 2.372 billion yuan, 2.696 billion yuan, and 3.138 billion yuan, respectively, with corresponding EPS of 0.98 yuan, 1.11 yuan, and 1.29 yuan [4].