Investment Rating - The report maintains a "Buy" rating for the company with a target price of HK13.15 [1][17][35]. Core Insights - The clinical data presented at the 2024 ASCO annual meeting shows that TST001 combined with nivolumab and CAPOX has a median progression-free survival (mPFS) of 12.6 months in patients with high/medium CLDN18.2 expression and 80% of PD-L1 CPS<5 patients [3][49]. - The company has optimized its R&D pipeline and resource allocation, resulting in a modest increase in R&D expenses to RMB 382 million in 2023, which is a year-on-year increase of RMB 32.2 million [5][51]. - The DCF valuation model indicates a weighted average cost of capital (WACC) of 9.8% and a terminal growth rate of 2.0%, leading to a new target price of HK14.07 [7][35]. Financial Analysis - The company's revenue for 2024E is projected at RMB 132 million, with a gross profit of RMB 33 million, and a net loss of RMB 527 million [32][58]. - R&D expenses for 2024E are expected to be RMB 396 million, reflecting a 21% reduction from previous estimates [5][37]. - The company anticipates a 15% growth in net profit for both 2024E and 2025E, with net losses decreasing from RMB 624 million to RMB 527 million in 2024E [5][37]. Valuation Overview - The DCF analysis estimates the equity value at HK14.07 per share, indicating a potential upside of 691% from the current share price of HK42 million, with a current share count of 184 million [48]. Clinical Development - The report highlights the significant clinical efficacy of TST001 in treating gastric or gastroesophageal junction cancer, particularly in patients with high/medium CLDN18.2 expression [39][49]. - The results from the Phase I/II clinical trials support the advancement of TST001 into Phase III trials, which have received regulatory approval from the FDA and CDE [39][49].
创胜集团-B：I/II期临床数据显示TST001三联疗法有望改善一线治疗胃或胃食管结合部腺癌患者治疗