司美格鲁肽最新减重数据刷新纪录：平均减重21%

Core Viewpoint - The recent STEP UP trial demonstrated that high-dose Wegovy® (semaglutide 7.2 mg) significantly reduces weight in non-diabetic obese individuals, with an average weight loss of 21%, and one-third of participants losing over 25% of their body weight [2][9]. Group 1: Trial Results - The STEP UP trial showed that semaglutide 7.2 mg resulted in a 20.7% average weight reduction compared to 17.5% for the 2.4 mg dose and 2.4% for the placebo group [2][8]. - In the 7.2 mg group, 93.2% of participants achieved at least a 5% weight loss, while 92.5% in the 2.4 mg group and only 35.7% in the placebo group reached this milestone [2][8]. - The trial included 1,407 adults with a BMI ≥30 kg/m² and was designed to assess the efficacy and safety of semaglutide 7.2 mg over 72 weeks [9]. Group 2: Safety and Tolerability - The 7.2 mg dose of semaglutide exhibited good tolerability consistent with previous studies, with gastrointestinal reactions being the most common side effects, typically mild to moderate [5][6]. - The discontinuation rate due to gastrointestinal side effects was low: 3.3% in the 7.2 mg group, 2.0% in the 2.4 mg group, and 0% in the placebo group [6]. Group 3: Future Developments - Novo Nordisk plans to submit an updated label application to the EU in the second half of 2025, followed by submissions in other markets where Wegovy® is approved [7]. - The company is also developing an oral formulation of Wegovy®, which, upon FDA approval, could become the first oral GLP-1 medication to achieve double-digit weight loss [3].