About this content About Emily Jarvie Emily began her career as a political journalist for Australian Community Media in Hobart, Tasmania. After she relocated to Toronto, Canada, she reported on business, legal, and scientific developments in the emerging psychedelics sector before joining Proactive in 2022. She brings a strong journalism background with her work featured in newspapers, magazines, and digital publications across Australia, Europe, and North America, including The Examiner, The Advocate, ...

Novo Nordisk may have found a winner in amycretin.Finally, some good news for Novo Nordisk (NVO 7.43%) shareholders!Twice in the past two months, the Danish manufacturer of GLP-1 drugs for weight loss and diabetes treatment has reported clinical trial results for refinements of its original Ozempic and Wegovy drugs. Twice in the past two months, investors have been disappointed by the numbers -- 22.7% average weight loss over 68 weeks for CagriSema, and 20.7% weight loss for a 72-week regimen of semaglutide ...

KEY TAKEAWAYSNovo Nordisk's U.S.-listed shares are surging 9% Friday morning after the Danish drugmaker reported early stage results for its amycretin weight-loss drug.The maker of Ozempic and Wegovy said that its Phase 1b/2a trial showed people achieved weight loss from a mean baseline body weight of 92.7 kg (202.8 pounds) in three different maintenance doses, while those treated with placebo gained weight.Novo Nordisk shares have been trending lower since September on slowing sales and increasing competit ...

Company Performance - Shares of Novo Nordisk jumped 9 5% at 11 02 a m London time following positive early-stage results for its once weekly amycretin obesity drug [1] - The trial showed an average weight reduction of 22% in obese and overweight patients after 36 weeks [1] Product Development - Novo Nordisk reported positive early-stage results for its once weekly amycretin obesity drug [1] - The drug demonstrated significant efficacy with a 22% average weight reduction in obese and overweight patients over 36 weeks [1]

Clinical Trial Results - Novo Nordisk announced topline results from a phase 1b/2a clinical trial for amycretin, a unimolecular GLP-1 and amylin receptor agonist intended for once-weekly subcutaneous administration [1] - The trial involved 125 people with overweight or obesity and investigated safety, tolerability, pharmacokinetics, and proof-of-concept over up to 36 weeks of treatment [2] - The primary endpoint was treatment-emergent adverse events, with the safety profile consistent with incretin-based therapies and most adverse events being mild to moderate gastrointestinal issues [3] Efficacy Data - Participants treated with amycretin achieved estimated body weight loss of 9.7% on 1.25mg (20 weeks), 16.2% on 5mg (28 weeks), and 22.0% on 20mg (36 weeks) from a mean baseline body weight of 92.7 kg [4] - Placebo-treated participants experienced estimated body weight gains of 1.9%, 2.3%, and 2.0% respectively [4] Company Commentary - Novo Nordisk expressed encouragement with the trial results, highlighting the weight-lowering potential of amycretin and its alignment with previous oral formulation results [5] - The company plans further clinical development of amycretin for adults with overweight or obesity [5] Product Background - Amycretin is a unimolecular long-acting GLP-1 and amylin receptor agonist under development for both oral and subcutaneous administration, targeting overweight, obesity, and type 2 diabetes [6] Trial Design - The phase 1b/2a trial was a randomised, placebo-controlled, double-blinded study conducted in five parts, exploring pharmacokinetics, safety, tolerability, and proof-of-concept over up to 36 weeks with dose escalation [7] Company Overview - Novo Nordisk is a global healthcare company founded in 1923, headquartered in Denmark, with a focus on defeating serious chronic diseases through scientific breakthroughs and expanding access to medicines [8] - The company employs approximately 72,000 people in 80 countries and markets products in around 170 countries [8]

Novo Nordisk’s (NVO) shares lost 5.3% on Friday after Medicare issued a press release selecting the company’s popular semaglutide medicines as one of the 15 additional drugs covered under Medicare Part D for the second round of price negotiations in 2025. Novo Nordisk markets its semaglutide medicines as Ozempic pre-filled pens and Rybelsus oral tablets for type II diabetes (T2D) and Wegovy injections for weight management.Any price reduction resulting from the impending negotiations will become effective i ...

Investors who Lost Money on Novo Nordisk A/S Should Contact Levi & Korsinsky About an Ongoing Investigation - NVO ...

About this content About Emily Jarvie Emily began her career as a political journalist for Australian Community Media in Hobart, Tasmania. After she relocated to Toronto, Canada, she reported on business, legal, and scientific developments in the emerging psychedelics sector before joining Proactive in 2022. She brings a strong journalism background with her work featured in newspapers, magazines, and digital publications across Australia, Europe, and North America, including The Examiner, The Advocate, ...

Novo Nordisk's ( NVO ; OTCPK:NONOF ) shares have seen an significant decline in late 2024, due to "disappointing" trial results. According to CNBC , trial patients of the new weight loss drug CagriSema only managed to achieveGerman Buy-Hold-Check investor. With a master's degree in both industrial engineering and economics, I am able to understand, quantify, and interpret both the economics and (to some point) the technology of companies.Analyst’s Disclosure: I/we have a beneficial long position in the shar ...

Popular obesity stocks fell on Tuesday after pharma giant Eli Lilly (LLY) lowered its sales guidance for full-year 2024 and announced disappointing preliminary fourth-quarter sales numbers.LLY’s Revised ’24 Sales View Below ExpectationsEli Lilly anticipates fourth-quarter revenues to reach approximately $13.5 billion, bringing the full-year total to $45 billion. However, the reported full-year figure fell short of the company’s previously projected range of $45.4-$46.0 billion shared in October. The reporte ...