Lilly(US:LLY) GLP1减重宝典·2025-09-02 12:49Core Viewpoint - Eli Lilly announced the termination of two Phase II clinical trials for the small molecule GLP-1 receptor agonist Naperiglipron (LY3549492) in the obesity and obesity-related type 2 diabetes sectors due to strategic business adjustments [2] Summary by Relevant Sections Naperiglipron (LY3549492) Overview - Naperiglipron is a small molecule GLP-1 receptor agonist that activates GLP-1 receptors to regulate blood sugar and suppress appetite, differing from traditional GLP-1 drugs by not relying on a peptide structure [5] - Clinical results indicate significant efficacy, with the ACHIEVE-1 Phase III study showing a reduction in hemoglobin A1C from a baseline of 8.0% by an average of 1.3%-1.6% after 40 weeks of treatment, and over 65% of patients in the highest dose group achieving A1C levels ≤6.5% [5] - In the ATTAIN-2 study for obese or overweight patients with type 2 diabetes, the highest dose group saw an average weight loss of 10.5% (10.4 kg) and a 1.8% reduction in A1C after 72 weeks, along with improvements in cardiovascular risk factors [5] - Safety profile is similar to other GLP-1 drugs, with common mild to moderate gastrointestinal side effects; the discontinuation rate due to adverse events in the highest dose group was 10.6%, with no liver-related risks identified [5] - Naperiglipron does not impose dietary or fluid restrictions, enhancing patient compliance [5]