Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 From the transition period from to Commission file number: 000-50633 CYTOKINETICS, INCORPORATED (Exact name of registrant as specified in its charter) (State or other jurisdict ...

Key Takeaways Cytokinetics reported a Q4 loss of $1.50 per share as operating expenses climbed year over year.CYTK gained FDA approval for Myqorzo in oHCM, with EU and China nods and Germany launch set for Q2 2026.Cytokinetics ended 2025 with $1.22B in cash as multiple late-stage aficamten studies advance globally.Cytokinetics (CYTK) reported a net loss of $1.50 per share for the fourth quarter of 2025, wider than the Zacks Consensus Estimate of a loss of $1.48. In the year-ago quarter, the company reported ...

Group 1 - E.ON plans to increase investments to 48 billion euros ($57 billion) over the next five years to expand and modernize energy grids [1][2] - The new investment plan for 2026 to 2030 is an increase from the previous 43 billion euro program for 2024 to 2028, indicating a strategic focus on enhancing regulated networks [2] - CEO Leonhard Birnbaum emphasized the need for a secure, affordable, and resilient energy system as it becomes larger, more decentralized, and complex [1]

Cytokinetics (CYTK) came out with a quarterly loss of $1.5 per share versus the Zacks Consensus Estimate of a loss of $1.48. This compares to a loss of $1.26 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of -1.63%. A quarter ago, it was expected that this biopharmaceutical company would post a loss of $1.59 per share when it actually produced a loss of $1.54, delivering a surprise of +3.14%.Over the last four quarters, the comp ...

Cytokinetics (NasdaqGS:CYTK) Q4 2025 Earnings call February 24, 2026 04:30 PM ET Company ParticipantsAlex Xenakis - Research AssociateAndrew Callos - EVP and CCOCory Kasimov - Senior Managing DirectorDiane Weiser - SVP of Corporate Communications and Investor RelationsFady Malik - EVP of Research and DevelopmentJackie Plesset - SMid Cap Biotech Equity Research AssociateJames Condulis - VP of Biotechnology Equity ResearchJoe Pantginis - Managing Director Equity ResearchMaxwell Skor - VP of Biotech Equity Res ...

Cytokinetics (NasdaqGS:CYTK) Q4 2025 Earnings call February 24, 2026 04:30 PM ET Company ParticipantsAndrew Callos - EVP and CCOCory Kasimov - Senior Managing DirectorDiane Weiser - SVP of Corporate Communications and Investor RelationsFady Malik - EVP of Research and DevelopmentJackie Plesset - SMid Cap Biotech Equity Research AssociateJames Condulis - VP of Biotechnology Equity ResearchJoseph Pantginis - Managing Director Equity ResearchMaxwell Skor - VP of Biotech Equity ResearchMayank Mamtani - Senior M ...

Cytokinetics (NasdaqGS:CYTK) Q4 2025 Earnings call February 24, 2026 04:30 PM ET Speaker13Thank you for standing by. Welcome to the Cytokinetics Fourth Quarter 2025 Earnings Call. This call is being recorded. All participants are in a listen-only mode. After the speaker's remarks, we will open the call to questions. We will allow for one question per participant. If you would like to ask a question during this time, simply press star followed by 1 on your telephone keypad. If you'd like to withdraw your que ...

Cytokinetics Reports Fourth Quarter 2025 Financial Results and Provides Business Update MYQORZO® Approved for Adults with Symptomatic Obstructive HCM in U.S., China and Europe; U.S. Launch Underway with First Prescriptions Dispensed within Days of Drug Availability Supplemental NDA for MAPLE-HCM Submitted to FDA in Q1 2026 Expect to Share Topline Results from ACACIA-HCM in Q2 2026 Company Provides 2026 Financial Guidance; ~$1.2 Billion in Cash, Cash Equivalents and Investments as of December 31, 2025 SOUTH ...

MYQORZO® Approved for Adults with Symptomatic Obstructive HCM in U.S., China and Europe; U.S. Launch Underway with First Prescriptions Dispensed within Days of Drug Availability Supplemental NDA for MAPLE-HCM Submitted to FDA in Q1 2026 Expect to Share Topline Results from ACACIA-HCM in Q2 2026 Company Provides 2026 Financial Guidance;~$1.2 Billion in Cash, Cash Equivalents and Investments as of December 31, 2025 SOUTH SAN FRANCISCO, Calif., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasd ...

Core Insights - Cytokinetics, Inc. is a biopharmaceutical company focused on developing treatments for cardiovascular diseases, leveraging over 25 years of expertise in muscle biology [1] - The company is set to release its fourth-quarter earnings on February 24, 2026, with investors closely monitoring the anticipated financial results [1] Financial Performance Expectations - Wall Street estimates that Cytokinetics will report an earnings per share (EPS) of -$1.48, with revenue expected to be around $8.02 million, indicating a quarterly loss [2] - The anticipated decline in earnings and revenue compared to the previous year suggests that the company may not achieve an earnings beat in its upcoming report [2] Financial Metrics Analysis - Cytokinetics has a negative price-to-earnings (P/E) ratio of -10.86, indicating it is not currently profitable [3] - The price-to-sales ratio is approximately 95.39, suggesting that investors are paying a high price for each dollar of sales [3] - The enterprise value to sales ratio is around 106.53, reflecting a premium valuation relative to its sales [3] Liquidity and Cash Flow - The company maintains a strong current ratio of 6.88, indicating its ability to cover short-term liabilities with short-term assets [4] - The enterprise value to operating cash flow ratio of -21.46 highlights difficulties in generating positive cash flow from operations [4] - The debt-to-equity ratio of -2.30 suggests more liabilities than equity, which could be a concern for investors [4] Upcoming Earnings Call - The earnings call scheduled for 4:30 PM Eastern Time on February 24 will be crucial for insights into the sustainability of stock price changes and future earnings expectations [5] - Investors can access the live webcast through the company's website, with an archived replay available for six months [5]