港股创新药概念股盘初调整，百济神州跌超5%，歌礼制药、山东新华制药（000756）股份、昭衍新药 （603127）跌超4%，君实生物、诺诚健华等股跌超3%。 ...

Core Viewpoint - The E Fund Healthcare Industry Mixed A Fund (110023) reported a profit of 535 million yuan in Q2 2025, with a weighted average profit per fund share of 0.4323 yuan, and a net value growth rate of 12.16% during the reporting period [3] Fund Performance - As of July 18, the fund's unit net value was 4.524 yuan, with a recent three-month net value growth rate of 34.04%, ranking 47 out of 138 comparable funds [4] - The fund's six-month net value growth rate was 54.03%, ranking 48 out of 138, and the one-year growth rate was 51.05%, ranking 46 out of 133 [4] - Over the past three years, the fund achieved a net value growth rate of 52.38%, ranking 7 out of 107 [4] Risk and Return Metrics - The fund's Sharpe ratio over the past three years was 0.4532, ranking 17 out of 105 comparable funds [9] - The maximum drawdown over the past three years was 24.99%, with the worst quarterly drawdown occurring in Q1 2021 at 24.73% [11] Investment Strategy - The fund underwent significant portfolio adjustments during the reporting period, reducing holdings in sectors like CXO and IVD, while concentrating investments in the innovative drug sector, based on a thorough analysis of the prospects for China's innovative drug industry [3] Fund Holdings - The fund's average stock position over the past three years was 92.35%, compared to an average of 86.91% for comparable funds, reaching a peak of 94.24% at the end of H1 2023 [14] - As of Q2 2025, the fund's top ten holdings included companies such as Heng Rui Medicine, Recbio Technology, and BeiGene, with a concentration exceeding 60% for the top ten holdings over the past two years [18] Fund Size - As of the end of Q2 2025, the fund's total size was 3.944 billion yuan [15]

Group 1 - The stock price of Nocera Biopharma (688428) closed at 30.6 yuan on July 18, 2025, down 0.33% with a turnover rate of 2.88% and a trading volume of 77,200 shares, amounting to a total transaction value of 235 million yuan [1] - On July 18, 2025, the net outflow of main funds was 11.82 million yuan, accounting for 5.02% of the total transaction value, while retail investors saw a net inflow of 7.19 million yuan, representing 3.06% of the total transaction value [2][4] - Nocera Biopharma submitted a disclosure report on July 18, 2025, indicating that the number of issued shares and treasury shares remained unchanged at 1,494,598,235 shares and 1,686,000 shares, respectively, totaling 1,496,284,235 shares [2] Group 2 - On July 18, 2025, Nocera Biopharma issued a total of 2,076,750 new RMB shares under the 2023 RMB Share Incentive Plan, with an issuance price of 6.95 yuan per share [3][4] - The issuance included 512,500 shares to 2 directors, 1,169,750 shares to 94 incentive recipients, and 394,500 shares to 42 incentive recipients, resulting in an increase in the total number of issued RMB shares from 266,282,967 to 268,359,717 shares [3]

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry as of July 20, 2025 [1] Core Insights - The establishment of a positive innovation cycle is driving value enhancement in the pharmaceutical sector, particularly through overseas collaborations and the increasing recognition of the value of PD-1/VEGF dual antibodies [2] - The focus on tri-antibodies is rising, with significant potential for competition in first-line treatments, as evidenced by recent collaborations and promising clinical data [3] - The trend towards more effective and scientifically-backed weight loss solutions is evident, with GLP-1 drugs projected to generate over $50 billion in global sales in 2024, significantly boosting capital interest [5] - The trend in autoimmune drug development is shifting towards innovative therapies, with notable advancements in dual-target fusion proteins [6] - The approval of Vuxinib (伏欣奇拜单抗) marks a significant milestone in biological treatments for gout, with a substantial market potential due to the increasing prevalence of hyperuricemia and gout [7] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry outperformed the CSI 300 index by 2.91 percentage points in the past week, with a weekly increase of 4.00%, ranking second among 31 primary industry indices [19] - Over the past month, the pharmaceutical sector outperformed the CSI 300 index by 5.90 percentage points, with an increase of 11.51%, ranking fourth among primary industry indices [21] 2. Pharmaceutical Sector Trends and Valuation - The pharmaceutical sector has shown a 14.50% increase over the past six months, outperforming the CSI 300 index by 4.46 percentage points [36] - The current PE (TTM) for the pharmaceutical sector is 37.25, which is above the five-year historical average of 32.24 [39] 3. Recent Research Achievements - The research team has published several in-depth reports highlighting the positive trends in supply and demand within the pharmaceutical industry, including the growth of blood products and the acceleration of the import substitution process in inhalation preparations [44] 4. Recent Industry Policies and News - Recent measures from the National Medical Insurance Administration aim to support the high-quality development of innovative drugs, enhancing their market access and clinical application [46] - Notable industry news includes the approval of new indications for existing drugs and significant collaborations between major pharmaceutical companies [47][49]

Core Viewpoints - The pharmaceutical and biotechnology sector is experiencing a turning point and structural market trends in the first half of 2025, with a focus on innovative drugs and their supply chain, AI healthcare, and brain-computer interfaces as structural opportunities [3][5] - The A-share pharmaceutical and biotechnology index has increased by 10.10% since the beginning of 2025, outperforming the CSI 300 index by 8.90 percentage points, ranking 4th in industry performance [3][22] - Among 480 listed pharmaceutical and biotechnology companies, 348 have seen their stock prices rise, accounting for 72.5%, with 17 stocks doubling in value [3][40] Investment Logic - The innovative drug sector is accelerating its value reconstruction through business development (BD) overseas, research and commercialization progress, and policy support. In the first half of 2025, over 50 BD transactions for innovative drugs occurred, totaling over $48 billion [5] - Significant clinical data releases and commercialization progress for major drug candidates are expected to drive stock price increases [5] - Policy initiatives, such as the March 2025 government work report emphasizing the support for innovative drugs and medical devices, are providing strong backing for the industry's long-term development [5] Market Performance - The pharmaceutical sector's valuation has seen a short-term recovery but remains at a long-term low, with a PE ratio of 29 times as of mid-2025, slightly above the 50th percentile of the past four years [3][43] - Public fund holdings in the pharmaceutical sector have increased, with the proportion of public funds in A+H shares rising to 9.05% in Q1 2025, a 0.37 percentage point increase [3][58] Sub-industry Performance - The best-performing sub-industries in the pharmaceutical sector include chemical preparations and other biological products, with increases of 25.8% and 24.0%, respectively [3][22] - The pharmaceutical industry is witnessing a structural market trend, with innovative drugs leading the charge, while traditional sectors like vaccines and traditional Chinese medicine have seen slight declines [3][29] Recommended Stocks - A robust portfolio is suggested, including companies such as Heng Rui Medicine, BeiGene, and United Imaging Healthcare, among others [10]

2025 年 07 月 20 日 投资评级：看好（维持） 医药生物 行业走势图 -24% -12% 0% 12% 24% 36% 2024-07 2024-11 2025-03 医药生物 沪深300 数据来源：聚源 相关研究报告 《CXO 龙头中报业绩超预期，重点关 注板块后续行情 — 行 业 周 报 》 -2025.7.13 《艾伯维收购 Capstan，加码体内 CAR-T—行业周报》-2025.7.6 《多款减肥药亮相 2025 ADA，重点关 注 AMYR 与 ActRII 靶点—行业周报》 -2025.6.29 集采政策明确优化，继续推荐制药板块性机会 ——行业周报 | 余汝意（分析师） | 刘艺（联系人） | 聂媛媛（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | liuyi1@kysec.cn | nieyuanyuan@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S0790124070022 | 证书编号：S0790124050002 | 集采政策持续优化，仿创 pharma 有望估值重塑 集采政策优化基调明确， ...

Core Viewpoint - The Hong Kong stock market is experiencing significant changes, with the Hang Seng AH Premium Index declining and reaching a new low for the year, indicating a narrowing premium of A-shares relative to H-shares, reflecting improved liquidity and value reassessment in the market [1] Group 1: AH Premium Rate Trends - The trend of narrowing AH premium rates is particularly evident at the individual stock level, with all 160 A+H listed companies seeing their AH premium rates drop below 200% [3] - The highest premium rate is for Chenming Paper, at 199.54%, contrasting sharply with the end of 2024 when over 10 stocks had premium rates exceeding 200% [3] - As of July 18, the number of stocks with premium rates over 100% has decreased to 32, down from 57 at the end of 2024, with BYD and Hongye Futures leading at 185.83% and 185.47% respectively [3] - Notably, four stocks are now trading at a discount of A-shares relative to H-shares, with CATL showing the largest discount at 24.63% [3] Group 2: Foreign Investment Trends - H-shares have performed strongly this year, supporting the narrowing premium rates, with seven H-shares doubling in value, including Rongchang Bio, which surged by 3.91 times [4] - Foreign institutions are increasingly favoring leading assets in the Hong Kong market, as evidenced by Wellington Management's purchase of 1.14 million shares of Hengrui Medicine for approximately 84.93 million HKD [4] - CATL's H-shares have seen a cumulative increase of 50.19% since their listing on May 20, with JPMorgan increasing its stake to 5.26% after purchasing 851,600 shares [4] - WuXi AppTec also attracted foreign investment, with FMR LLC increasing its holdings to 14.04% after buying 1.72 million shares [4] Group 3: Structural Changes in the Market - The Hong Kong stock market is undergoing structural changes, with new economy sectors like innovative pharmaceuticals, new energy, and consumer electronics rapidly emerging [5] - These sectors demonstrate stronger profit growth certainty and align better with global investors' long-term allocation preferences [5] - There is a noticeable differentiation in market structure, with large-cap companies having significantly lower premium rates compared to small-cap companies, indicating institutional investors' growing recognition of industry leaders and companies with solid fundamentals [5]

Core Insights - The AI Fund Ping An Medical Health Mixed A (003032) reported a profit of 210 million yuan for Q2 2025, with a weighted average profit per fund share of 0.5108 yuan [2] - The fund's net value growth rate for the reporting period was 21.53%, and as of the end of Q2, the fund size was 966 million yuan [2] - The fund focuses on equity mixed investments, particularly in pharmaceutical and medical stocks, and has a current unit net value of 2.876 yuan as of July 17 [2] Performance Metrics - The fund manager highlighted a strategy based on the economic conditions of sub-industries, focusing on innovative drugs and medical devices as growth sectors [2] - As of July 17, the fund's one-year adjusted net value growth rate was 84.73%, ranking 5th out of 133 comparable funds [2] - The fund's three-month adjusted net value growth rate was 43.84%, ranking 9th out of 138 comparable funds [2] Risk and Volatility - The fund's three-year Sharpe ratio was 0.4698, ranking 15th out of 105 comparable funds [6] - The maximum drawdown over the past three years was 38.67%, with the largest single-quarter drawdown occurring in Q1 2024 at 30.45% [8] Investment Strategy - The fund maintained an average stock position of 90.2% over the past three years, compared to the industry average of 86.9% [11] - The fund's top ten holdings include companies such as CloudTop New Medicine, Innovent Biologics, and BeiGene, indicating a high concentration in its portfolio [15]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 諾誠健華醫藥有限公司（於開曼群島註冊成立的有限公司） 呈交日期： 2025年7月18日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 09969 | 說明 | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | 已發行股份（不包括庫存股份）數 目 | 佔有關事件 ...

Core Viewpoint - As of July 18, 160 stocks reached their 52-week highs, with notable performances from China New Economy Investment (00080), Aoyuan Group Equity (02905), and Zhong An Holdings Group (08462) showing high growth rates of 288.89%, 55.28%, and 50.00% respectively [1][2]. Summary by Category 52-Week High Performers - China New Economy Investment (00080) closed at 0.440, with a peak price of 0.700, achieving a growth rate of 288.89% [2]. - Aoyuan Group Equity (02905) closed at 0.218, with a peak price of 0.250, achieving a growth rate of 55.28% [2]. - Zhong An Holdings Group (08462) closed at 0.221, with a peak price of 0.228, achieving a growth rate of 50.00% [2]. - Other notable performers include Hualian International (00969) with a growth rate of 40.13% and Zhongke Bio (01237) with a growth rate of 37.25% [2]. Additional High Performers - Wanma Holdings (06928) closed at 0.550 with a growth rate of 30.43% [2]. - Lepu Biopharma-B (02157) closed at 7.940 with a growth rate of 24.54% [2]. - Other stocks with significant growth include ZhiJianYueDong (06860) at 17.14% and China Jindian Group (08281) at 17.12% [2]. 52-Week Low Performers - The document also lists stocks that reached their 52-week lows, with XI Ernan CO-U (09311) showing a decline of 16.10% [6]. - Other notable declines include XI Ernan CO (07311) at -12.62% and Haotian International Construction Investment (01341) at -5.70% [6].