This story was originally published on MedTech Dive. To receive daily news and insights, subscribe to our free daily MedTech Dive newsletter. Medical device mergers and acquisitions accelerated in the second half of 2025, propelled by several large deal announcements, according to a report released this month by Bain & Company. Medtech M&A brought in a total value of about $80 billion through Nov. 30, 2025, surpassing the previous three years. Much of the activity took place in the second half of the ye ...

Core Insights - The company has undergone a transformation process over the past five years, enhancing its commercial strength, revitalizing innovation, and entering fast-growing adjacencies, which facilitated the acquisition of BD's Bioscience and Diagnostics business [2][3]. Group 1: Company Strategy - The acquisition of BD's Bioscience and Diagnostics business is seen as a strategic move to create value for the corporation in the coming years [3]. - The company aims to execute its strategy from a position of strength, focusing on value creation and future strategic and financial perspectives [3]. Group 2: Market Position - The company addresses significant unmet needs for customers who invest approximately 10% of product sales in R&D, aiming to transform complex instrumentation into useful systems for high-volume regulated applications [4]. - There are roughly 170,000 instruments placed across various customers in regulated laboratories and other settings, indicating a strong market presence [4].

Summary of Conference Call Company and Industry - **Company**: Waters Corporation - **Industry**: Life Sciences and Analytical Instruments Key Points and Arguments Replacement Cycle and Growth Drivers - The replacement cycle for instruments, particularly LCMS, began about a year ago and is expected to continue for several more years, with current growth rates in the high single digits [2][4] - The growth drivers for LCMS include: 1. Instrument replacement cycle, which is still ongoing [2] 2. Idiosyncratic growth drivers such as GLP-1 testing, which has seen revenues double, and PFAS testing, which has 30% order growth [3] 3. Development of new products that meet significant unmet needs in the market [3] Performance in Different Segments - Chemistry segment grew by 13% in the third quarter, significantly above the pre-COVID run rate of 6%-7% [5] - The growth in chemistry is attributed to investments in bioseparations and innovations in product offerings, particularly for biologics [6][7] - The pharma segment experienced double-digit growth driven by the replacement cycle and idiosyncratic growth drivers, particularly in the U.S. and Europe [10][11] Regional Insights - In China, growth is driven by CDMOs supporting the local biotech industry, with a significant share of global in-licensing coming from China [11] - India is experiencing high teens growth driven by generics, while branded generics in China are still declining [11] Innovation and New Products - The CDMS opportunity is highlighted as a significant unmet need in the market, with potential to capture a large share of the $350 million annual sales currently dominated by existing techniques [16][17] - New product launches include the FACS DiVa S8 flow cytometer and the FXI incubator for microbiology, both expected to drive significant growth [22][23] Software and Commercial Model Changes - The Empower software business is a critical part of Waters' portfolio, with plans to transition to a subscription model to enhance revenue [30][31] - The Empower system is used for 80% of QAQC data submissions for drugs filed to regulatory bodies, indicating its importance in the industry [30] Market Dynamics and Future Outlook - The overall market setup is positive, with continued growth expected from the replacement cycle, new product introductions, and idiosyncratic growth drivers [38] - The company anticipates that the growth rate in chemistry will stabilize in the high single digits to low double digits over time [7] Additional Insights - The company is focusing on integration planning post-acquisition, with positive surprises in microbiology workflow improvements and potential market entry strategies [26] - The pricing strategy for large molecules is expected to be stickier and more significant compared to small molecules, enhancing revenue opportunities [9] Other Important Content - The company is actively working on enhancing its product offerings and market strategies to capture unmet needs and drive sustainable growth [17][38] - There is a focus on customer adoption and integration of new technologies, which is crucial for maintaining competitive advantage in the market [17][31]

Summary of the Conference Call for Anbiping Company Overview - **Company**: Anbiping - **Industry**: Medical diagnostics, specifically focusing on HPV products, AI in healthcare, and pathology services Key Financial Performance - **Revenue**: Third quarter revenue decreased by 24.95% year-on-year, totaling 253 million RMB, with a total profit loss of 1,741 million RMB, a decline of 187% [2][3] - **Net Profit**: Net profit attributable to the parent company was a loss of 173 million RMB, down 86.95% year-on-year [2][3] - **HPV Product Line**: The HPV product line's gross profit decreased by 79.35%, amounting to a reduction of 41.04 million RMB due to centralized procurement policies [2][3][7] AI and Digitalization Progress - **AI Certification**: The company expects to obtain AI Class III certification for its liquid-based cytology (LBC) by Q1 next year, which will enhance its market presence [2][4][6] - **Hospital Trials**: AI and scanning devices have been trialed in over 10 hospitals, but unclear pricing standards have hindered broader adoption [6][24] - **Digital Business**: The digital business includes partnerships for hospital digitalization and product line revenue growth, with specific revenue forecasts for 2025 and 2026 still under development [22] Business Development Areas - **Pathology Co-construction**: This area has seen a revenue increase of approximately 45% year-on-year, reaching 19 million RMB, with 76 co-construction points established [2][8][11] - **Marketing Strategy**: Transitioning from direct sales to distribution has led to the development of nearly 200 new immunohistochemistry clients and 50 new clients for Fisher [13] Future Expectations - **ADP Impact**: The impact of ADP is expected to diminish significantly after Q4 2025, with a positive shift in net profit observed in Q3 [9] - **Market Share Growth**: Following the acquisition of Haoluo Jie, Anbiping anticipates an increase in market share, particularly in major urban hospitals [4][18] - **Sales Performance**: The company aims to maintain or slightly grow its market share, with approximately 6-6.3 million annual outpatient volumes expected [19] Challenges and Competitive Landscape - **Price Pressure**: The company faces price pressures in the immunohistochemistry sector, with over 60 competitors in the market [20] - **Regulatory Environment**: The lengthy application process for AI Class III certification is seen as a challenge, but the company believes its extensive pre-trial data will provide a competitive edge [21] Strategic Goals - **Growth Areas**: Future growth will focus on LBC, immunohistochemistry, and fluorescence in situ hybridization, with plans to leverage AI capabilities [25][26] - **Marketing Initiatives**: The company plans to enhance its market share in high-end hospitals and explore new markets through innovative sales strategies [27] Conclusion Anbiping is navigating a challenging financial landscape with significant declines in revenue and profit, primarily due to centralized procurement policies affecting its HPV product line. However, the company is making strides in AI and digitalization, with a focus on expanding its market share and improving profitability through strategic partnerships and marketing reforms.

Financial Data and Key Metrics Changes - The company reported high single-digit growth in instrumentation, with a notable performance in the base business, continuing momentum from previous quarters [3][4] - Service attachment rates have reached 52%, and e-commerce penetration is above 45% [4] - The company experienced a 20% decline in TA in the U.S., primarily due to R&D testing in material science, while international markets, particularly China, showed strong growth [7][8] Business Line Data and Key Metrics Changes - New product launches contributed significantly to the overall growth, with the Alliance IS achieving three times the sales compared to last year and TQ Absolute XR setting new standards in its category [5][18] - PFAS testing grew by 30% this quarter, although it slowed from 90% growth in Q1, with year-to-date growth close to 50% [6] - GLP-one testing saw a 70% increase in the first half of the year, and India generics experienced growth in the high teens to low twenties [6] Market Data and Key Metrics Changes - The U.S. market for TA declined, but outside the U.S., growth was robust, particularly in China, which saw double-digit growth driven by CDMO activity [7][8] - The LCMS segment maintained high single-digit growth, indicating a healthy replacement cycle still in progress [9][10] Company Strategy and Development Direction - The company aims to build a biologics QC domain, focusing on acquiring technologies and capabilities to enhance its portfolio, particularly in mass spectrometry and flow cytometry [21][24] - Strategic synergies from the recent acquisition are expected to yield significant operational improvements, with a target of $200 million in synergies identified [26][39] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the growth in China, particularly in the pharma segment, despite a cautious outlook for the remainder of the year [70][71] - The company is focused on maintaining its base business performance while preparing for the integration of the new acquisition [53][54] Other Important Information - The company plans to raise $4 billion in debt to fund the acquisition, with an expected leverage ratio of about 2.5 to 2.6 [63] - Management emphasized the importance of cultural integration and maintaining operational efficiency during the merger process [56][58] Q&A Session Summary Question: What is the state of the instrument replacement cycle? - Management indicated that the replacement cycle is progressing well, with high single-digit growth in LCMS, suggesting that there is still significant room for growth beyond the average [9][10] Question: How is the CapEx approval process evolving? - The company noted that while the replacement cycle is strong, the velocity of the CapEx approval process has not improved post-pandemic [14][15] Question: What are the competitive dynamics in the LC market? - Management highlighted that displacing competitors in the replacement segment is challenging, but new product offerings have been well received, leading to significant growth in that area [16][17] Question: How will the company integrate with BD post-acquisition? - The integration plan involves securing the base business, validating plans developed pre-announcement, and identifying key individuals accountable for delivering synergies [53][56] Question: What is the outlook for the generics industry amidst tariff discussions? - Management indicated that the generics industry is exempt from tariffs, and there are no significant concerns regarding the impact of tariffs on the business [64][66]

Financial Data and Key Metrics Changes - The company reported high single-digit growth in instrumentation, with a notable performance in the base business, continuing momentum from previous quarters [3][4] - Service attachment rate reached 52%, and e-commerce penetration exceeded 45% [4] - The company experienced a 20% decline in TA in the U.S., primarily due to R&D testing in material science, while international markets, particularly China, showed strong growth [7][8] Business Line Data and Key Metrics Changes - New products contributed significantly to the overall growth, with Alliance IS sales tripling compared to the previous year and TQ Absolute XR setting new standards in its category [5][6] - PFAS testing grew by 30% this quarter, although it slowed from 90% growth in Q1, with year-to-date growth close to 50% [6] - The generics market in India showed growth in the high teens to low twenties percentage range [7] Market Data and Key Metrics Changes - The U.S. experienced a decline in TA, while China reported high single-digit to double-digit growth driven by CDMO activity [8] - The company noted that the LCMS growth remained strong, indicating that the replacement cycle is still ongoing, with significant growth potential in segments that have not yet participated [9][12] Company Strategy and Development Direction - The company aims to build a biologics QC domain, focusing on acquiring bioanalytical instruments and reagents, particularly antibodies [22][24] - The strategic fit of the recent acquisition was emphasized, with plans to enhance operational improvements and synergies [26][28] - The company is focused on maintaining its base business while integrating the new acquisition, ensuring that cultural elements from both organizations are respected [58][60] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about growth in China, particularly in the pharma and CDMO segments, despite some challenges in the generics market [70][72] - The company is cautious about future growth, projecting low to mid-single-digit growth in China for the remainder of the year [71][72] - Management highlighted the importance of operational improvements and synergies from the acquisition, with a focus on execution and accountability [61][63] Other Important Information - The company plans to raise $4 billion in debt to fund the acquisition, with an expected leverage ratio of about 2.5 to 2.6 [64] - There is a focus on cultural integration and ensuring that the strengths of both companies are leveraged effectively [59][60] Q&A Session Summary Question: What are the growth drivers in the current market? - Management highlighted the ongoing replacement cycle in the LCMS market and the strong performance of new products as key growth drivers [9][10] Question: How does the company plan to integrate the new acquisition? - The integration will focus on maintaining the base business while validating plans developed prior to the acquisition announcement, with a clean team to oversee the process [56][58] Question: What are the expected synergies from the acquisition? - The company anticipates $200 million in cost synergies, with potential for additional savings based on operational improvements [26][38] Question: How is the company addressing cultural integration post-acquisition? - Management emphasized the importance of respecting the existing cultures of both organizations and focusing on execution and accountability [59][60]

Core Insights - QuidelOrtho Corporation has appointed Erich Wolff as Executive Vice President, Strategy & Corporate Development, to lead enterprise strategy and business development [1][2] - Mr. Wolff has over 20 years of experience in strategy, M&A, and business development in the healthcare and diagnostics sectors [2][3] - The company aims to leverage Mr. Wolff's expertise to enhance its growth strategies and deliver long-term value [3][4] Company Overview - QuidelOrtho is a global leader in in vitro diagnostics, focusing on developing intelligent diagnostic solutions [6][7] - The company provides fast, accurate, and reliable diagnostics across various settings, including home, hospital, lab, and clinic [7] - QuidelOrtho emphasizes innovation and collaboration with global healthcare customers to advance diagnostic capabilities [7]

Summary of Conference Call for Anbiping Company Overview - **Company**: Anbiping - **Industry**: Medical diagnostics, specifically focusing on HPV screening, immunohistochemistry, and AI applications in pathology Key Points and Arguments Market Strategy and Performance - Anbiping's shift from direct sales to distribution has impacted factory prices, but sales volume increased in Q2 2025, with expectations of recovery in the second half of the year as the impact of centralized procurement (集采) ends in August [2][3] - The company has received 13 CE certifications for immunohistochemistry and liquid-based cytology, which are crucial for its international expansion strategy [2][5] - The HPV screening market penetration is high, with a growth rate of approximately 7% in Q1 2025, driven by national initiatives to eliminate cervical cancer by 2030 [2][6] Competitive Landscape - Major player Capbio holds over 30% market share, and the market share distribution remains stable post-centralized procurement, limiting new entrants due to price pressures [2][7] - Anbiping's AI cervical cytology product has been commercialized, with 296 scanners sold, capturing about 15% market share [2][8] Financial Performance - In Q1 2025, Anbiping's revenue declined by 28% due to a drop in factory prices from 45 RMB to 13 RMB as a result of centralized procurement [3] - The company anticipates a net profit margin of over 15% in the future, despite current challenges [4][27] Research and Development - Anbiping plans to invest 70 million RMB in R&D in 2025, focusing on immunohistochemistry and AI technologies [4][14] - The company aims to enhance its AI product quality and explore new business models, as current regulations prevent separate charging for AI services [9][16] Future Outlook - The immunohistochemistry market is growing at an annual rate of about 20%, with Anbiping targeting 1 billion RMB in revenue from this segment [2][10] - The company is prioritizing the promotion of its AI cervical cytology product due to its higher revenue potential compared to HPV testing [21] - Anbiping's overseas sales are expected to double in 2025, with a focus on Southeast Asia and Europe, avoiding highly competitive markets like the U.S. [22][23] Regulatory and Market Challenges - The company faces challenges from centralized procurement and channel adjustments but sees opportunities from competitors exiting the Chinese market [25][29] - The pathology industry is expected to grow, with potential price increases for diagnostic services due to policy support [20] Conclusion - Anbiping is navigating a challenging environment with strategic adjustments in sales, a focus on R&D, and leveraging market opportunities from competitor exits. The company is positioned for potential growth in the coming years, particularly in the AI and immunohistochemistry sectors [28][29]

Transaction Overview - BD will separate its Biosciences and Diagnostic Solutions business to BD shareholders and simultaneously merge SpinCo with a wholly owned subsidiary of Waters in a tax-efficient Reverse Morris Trust transaction valued at approximately $17.5 billion[65] - Expected pro forma ownership of 60.8% for Waters shareholders and 39.2% for BD shareholders[65] - BD to receive approximately $4 billion cash distribution via proceeds of SpinCo debt[65] - The transaction is expected to close around the end of the first quarter of calendar year 2026[65] Financial Highlights - Pro forma revenue for CY 2025E is approximately $6.5 billion[18] - Adjusted EBITDA for CY 2025E is approximately $2.0 billion[18] - R&D spending is approximately 10% of sales[18] - The transaction is expected to be EPS accretive in Year 1[36] - Expected revenue synergies of approximately $290 million by Year 5, with an EBITDA impact of $145 million[33, 61] - Expected cost synergies of approximately $200 million by Year 3[33, 61] - Approximately $345 million in total annualized adjusted EBITDA synergies are expected by Year 5[36, 61] Growth and Stability - The combined company will have a total addressable market (TAM) of approximately $40 billion with 5-7% market growth[19, 22] - Over 70% of revenue is annually recurring[19, 30] - Over 50% of instruments are replaced every 5-10 years[19, 30] - Expected sales growth in the near-to-mid-term is MSD-HSD (Mid-Single-Digit to High-Single-Digit)[33] - Adjusted operating margin expansion of approximately 500 bps is expected by 2030[33]

Core Insights - The In Vitro Diagnostics (IVD) market was valued at USD 94.7 billion in 2024 and is projected to reach USD 141.9 billion by 2029, with a compound annual growth rate (CAGR) of 8.40% [1][13]. Market Overview - The report covers IVD technologies and devices used in hospitals and point-of-care facilities for disease diagnosis, detailing current and future market potential, competitive environment, and market dynamics [2][5]. - IVDs are crucial in the healthcare industry, encompassing analyzers, reagents, and software products, and are used for diagnosing infectious and chronic diseases [5][6]. Market Segmentation - The immunochemistry segment was valued at USD 31.1 billion in 2023, with an estimated growth rate of 5.5% CAGR, attributed to increased diagnostic procedures and demand for blood sample analysis [4]. - The report includes market analysis by technology, application, end user, and region, highlighting segments such as molecular diagnostics, hematology, and point-of-care testing [17]. Market Drivers and Trends - Key drivers for market growth include aging demographics, rising healthcare demands in developing countries, and a shift towards preventive healthcare [7]. - Emerging segments like companion diagnostics and next-generation sequencing are expected to significantly contribute to market growth [7]. Competitive Landscape - North America is the largest market for IVDs, with emerging markets in India, China, Russia, and Brazil expected to grow at double-digit rates due to increasing healthcare budgets and health awareness [9]. - The report assesses the competitive landscape, including market shares of key players such as F. Hoffmann-La Roche Ltd., Abbott, and Siemens Healthineers AG [12][22]. Regulatory and Technological Developments - The report discusses the regulatory landscape for IVD products across different countries and highlights the importance of FDA approvals for new technologies [17]. - Technological advancements, including artificial intelligence and lab automation, are shaping the future of IVDs, enhancing diagnostic capabilities and efficiency [17].