Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions including Peking University Ningbo Institute of Ocean Medicine and the China Society of Biotechnology [2]. Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes who will share insights on biomanufacturing innovations [4][5][6][7]. Conference Agenda - The event will feature a series of forums and discussions, including a high-level roundtable on biomanufacturing, thematic forums on green chemicals and new materials, AI in biomanufacturing, and future food and agriculture [36][37]. Key Topics of Discussion - Topics will cover the construction of efficient cell factories for aromatic compounds, biomanufacturing of polyamide materials, and advancements in enzyme engineering for low-carbon biomanufacturing [8][11][27]. Networking and Collaboration - The conference aims to facilitate technology transfer, product scaling, and talent acquisition within the biomanufacturing sector, promoting collaboration among industry leaders, researchers, and government entities [1]. Event Details - The SynBioCon 2025 will take place from August 20 to 22 in Ningbo, Zhejiang, featuring registration, networking opportunities, and a showcase of technological achievements in the biomanufacturing field [1][36].

全球政策进展 | 青岛市 【SynBioCon】 获 悉，近日青岛市 发布 《青岛市合成生物创新发展行动方案（ 2025-2027 年）》 近日公布，部分内容如下： 一、总体要求 针对合成生物交叉范围广、技术开发壁垒高、应用领域广泛、产业发展潜力大等特点，以创新为动力，以企业为主体，以场景为牵引，以标志性产品为 抓手，推动合成生物技术广泛赋能医疗健康、环境保护、农业生产、能源化工等重要产业高质量发展，加快形成新质生产力，全面提升青岛合成生物科 技创新策源能力和产业发展能级。 到 2027 年，力争突破关键技术不少于 30 项，形成国际先进水平创新成果不少于 5 项 ，新增生物制造领域各级创 新平台不少于 5 个，打造标志性产业化项目不少于 10 项 ，培育一批高成长企业，瞪羚、专精特新、科技领军企业总计突破 30 家 ，新增具有国际影 响力的顶尖科学家团队不少于 2 个，打造特色鲜明、优势突出的产业载体或专业园区，建好用好青岛合成生物技术创新联盟和合成生物产业基金，营造 创新活跃、转化顺畅、主体繁荣、要素完备的产业生态，构建国内独具优势、彰显青岛特色的合成生物制造产业体系。 二、重点任务 （一）实施底层技术迭 ...

Core Insights - Senti Bio is presenting its innovative logic-gated CAR-NK cell therapy, which targets leukemic cells while preserving healthy bone marrow [1] - The presentation will take place at the BioScience Forum on July 23, 2025, featuring Dr. Kanya Rajangam as the speaker [2] Company Overview - Senti Bio is a clinical-stage biotechnology company focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [1][4] - The company aims to create therapies that can precisely kill cancer cells while sparing healthy cells, enhancing specificity to target tissues, and allowing control post-administration [4] - Senti Bio's pipeline includes cell therapies engineered with Gene Circuits targeting both liquid and solid tumors, with preclinical evidence supporting their efficacy in NK and T cells [4]

Core Insights - The article highlights significant advancements in various fields of research published in the journal Cell, with a notable contribution from Chinese scholars, indicating a strong presence in cutting-edge scientific research [1]. Group 1: Measles Virus Research - A study by Zhang Heqiao and Roger Kornberg's team elucidated the structure of the measles virus polymerase complex and its interaction with non-nucleoside inhibitors, laying the groundwork for rational antiviral drug design [3][4]. Group 2: AI in Protein Engineering - The research team led by Gao Caixia developed a novel AI protein engineering simulation method called AiCE, which integrates structural and evolutionary constraints, enabling efficient protein evolution simulation and functional design without the need for specialized AI model training [7]. Group 3: Vertebrate Genomics - The team from Zhejiang University introduced a high-throughput, sensitive single-nucleus ATAC sequencing technology (UUATAC-seq) to create chromatin accessibility maps, and developed the Nvwa model for predicting cis-regulatory elements, revealing the conserved syntax of vertebrate regulatory sequences [10][11]. Group 4: Primate Brain Research - A study identified cell type-specific enhancers in the macaque brain, establishing tools for understanding primate brain structure and diseases, which could enhance insights into cognitive functions [15]. Group 5: Peripheral Nerve Imaging - Researchers from the University of Science and Technology of China pioneered a high-speed, subcellular resolution imaging technique for whole-mouse peripheral nerves, providing a detailed peripheral nerve atlas and new tools for studying nerve regulation and disease mechanisms [19]. Group 6: Primate Prefrontal Cortex Connectivity - A study reconstructed the whole-brain connectivity network of the macaque prefrontal cortex at the single-neuron level, revealing refined axon targeting and arborization, which is crucial for understanding complex cognitive functions in primates [23]. Group 7: Optogenetics in Drug Discovery - The research led by Felix Wong developed an optogenetics platform for discovering selective modulators of the integrated stress response, identifying compounds that enhance cell death without toxicity, and demonstrating antiviral activity in a herpes simplex virus mouse model [27][28]. Group 8: Engineering Yeast Behavior - A study from Imperial College London established engineering principles for yeast, enabling programmable multicellular behaviors, transforming yeast from a "single-cell factory" to a "multicellular system chassis" [33][34].

Group 1 - The article highlights the importance of weekly announcements from Sunday to Thursday, which include significant stock market updates such as suspensions, investments, acquisitions, earnings reports, and stock unlockings [1] - It emphasizes the need for investors to identify potential investment hotspots and to guard against various black swan events by having ample time to analyze and select suitable listed companies [1] Group 2 - A company with deep technical reserves in digital currency is mentioned, indicating its strong position in the digital currency and blockchain sectors [1] - Another company is noted for its stable supply relationships with mainstream PCB manufacturers, linking it to the PCB concept, chips, photoresist, and photovoltaics [1] - A company is highlighted for its cash acquisition of semiconductor equity, connecting it to chips, synthetic biology, hydrogen energy, and energy storage [1]

Industry Overview - The field of genomics has rapidly evolved over the past decade, focusing on the complete set of genes and their interactions rather than individual genes [1] - Genomics is pivotal for developing targeted therapies, leading to a revolutionary era in genetic medicine, attracting significant attention from pharmaceutical and biotech companies [2] Technological Innovations - Synthetic biology, which applies engineering principles to biology, has emerged as a key concept within genomics, aiding in drug discovery, disease detection, and gene editing [3] - The cost, accuracy, and time required to map an individual's genome have drastically reduced, enhancing the spotlight on genomics companies [4] Market Potential - The genomics market is projected to reach $157.47 billion by 2033, while the global synthetic biology market was valued at $16.22 billion in 2024, with a projected CAGR of 17.30% from 2025 to 2030 [6] Company Highlights - MeiraGTx Holdings plc is focused on genetic medicine with a pipeline addressing conditions like Parkinson's disease and retinal dystrophy, showing promising efficacy data [8][9] - Beam Therapeutics is advancing base editing programs for genetic diseases, with FDA orphan drug designation for its BEAM-101 treatment for sickle cell disease [12][13] - Krystal Biotech received FDA approval for Vyjuvek, the first gene therapy for dystrophic epidermolysis bullosa, and is advancing a pipeline in various therapeutic areas [14][15]

Core Insights - Senti Biosciences, Inc. is a clinical-stage biotechnology company focused on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform [1][3] - The company will present at the 2025 Synthetic Biology: Engineering, Evolution, & Design (SEED) Conference, highlighting its innovative approach to tumor-specific therapies [1] Company Overview - Senti Bio is dedicated to creating new cell and gene therapies for patients with incurable diseases, utilizing synthetic biology to engineer Gene Circuits for enhanced precision and control [3] - The company's pipeline includes cell therapies designed to target both liquid and solid tumors, with preclinical evidence supporting the efficacy of Gene Circuits in NK and T cells [3] Conference Details - The SEED Conference, established in 2014, serves as a premier event for synthetic biologists, facilitating networking and collaboration among over 5,000 professionals in the field [1] - Senti Bio's presentation will focus on "Solving the Grand Challenge of Tumor-Specific Therapies with Logic-Gated Cells," showcasing its advancements in the field [1]

Core Viewpoint - The article highlights the increasing investment in AI and robotics industries in Guangdong, with the establishment of two major funds totaling 200 billion RMB, reflecting the urgency and strategic approach of the region in fostering these sectors [4][5]. Fund Establishments - Guangdong has launched its first AIC Artificial Intelligence Industry Fund in March, with a scale of 10 billion RMB, focusing on AI and robotics investments [4]. - A new Guangdong Intelligent Industry Fund has been initiated, also with a scale of 10 billion RMB, targeting AI, robotics, and semiconductor sectors [5]. - The Hubei Province has established a humanoid robot industry investment fund with a total investment of 5 billion RMB, aiming to enhance its capabilities in the humanoid robot sector [11]. - The Hangzhou West Lake Future Venture Capital has been set up with a capital of 2 billion RMB, focusing on early-stage investments [12]. - The Jiangsu Province has seen the establishment of a 3 billion RMB angel fund focusing on biopharmaceuticals, supported by local government and industry investors [14][15]. Investment Dynamics - Chaoxi Capital has successfully closed its second RMB fund with a first close of 700 million RMB, indicating strong support from industrial LPs [7]. - The Shenzhen AI Terminal Industry Private Equity Fund has been established with a capital of 1.44 billion RMB, aligning with Honor's strategic shift towards AI ecosystem development [17]. - The establishment of the Qihang He Wu Entrepreneurship Investment Partnership in Changzhou, focusing on synthetic biology, highlights the region's commitment to emerging technologies [18]. GP Recruitment - The Suqian New Emerging Industry Mother Fund has been set up with a scale of 2 billion RMB, seeking to recruit GP for strategic investments in various emerging industries [27]. - The Nanjing Pukou District High-Quality Development Mother Fund is also looking for GP, focusing on integrated circuits, new energy, and AI [28][29].

Group 1 - Synthetic biology is a new direction for productivity transformation and upgrading, integrating multiple disciplines to design and construct new biological systems for specific functions [1] - The current global synthetic biology industry is in a rapid development phase, with domestic policies continuously strengthening support, creating rich investment opportunities across the industry chain [1][2] - AI technology significantly enhances research and development efficiency through modeling and simulation, which will continue to empower synthetic biology research in China [2] Group 2 - The international advantages in synthetic biology are primarily concentrated in the US and Europe, with domestic policies being developed at the provincial and municipal levels to guide and support the industry [2] - The synthetic biology industry chain consists of three layers: upstream tool layer focusing on enabling technology development, midstream platform layer providing empowering technology platforms, and downstream application layer delivering innovative products to various vertical industries [3] - Each layer of the synthetic biology industry has distinct core barriers, with patents being important but not encompassing the entire industry's core challenges [3]

Industry Overview - The rapid evolution of genomics is leading to a revolutionary era in genetic medicine, driven by the need for innovative medical treatments [1] - Genomics focuses on the complete set of genes and their interactions, rather than individual genes, which is attracting attention from pharma and biotech companies [2] - Breakthroughs in genomics have enabled the development of targeted therapies based on individual genetic information [2] - The genomics market is projected to reach $157.47 billion by 2033, while the global synthetic biology market was valued at $16.22 billion in 2024 and is expected to grow at a CAGR of 17.30% from 2025 to 2030 [6] Key Companies - Illumina (ILMN) is a major player in the genomics sector, known for its sequencing and array-based solutions for genetic analysis [4] - Gene editing companies like BEAM Therapeutics (BEAM) and CRISPR Therapeutics AG (CRSP) are developing technologies such as CRISPR/Cas9 to treat diseases caused by genetic variants [5] Investment Opportunities - Intellia Therapeutics (NTLA) is focused on CRISPR-based therapies for diseases with high unmet needs, with lead candidates in phase III studies [8][9] - uniQure (QURE) is advancing gene therapies for conditions like Huntington's disease and has received Breakthrough Therapy designation for AMT-130 [11][12] - Verve Therapeutics (VERV) is developing gene editing medicines for cardiovascular disease, targeting genes like PCSK9 and ANGPTL3 [14][15]