Opioid Crisis & Regulatory Reform - FDA 承认在阿片类药物监管方面存在失败，并对由此造成的阿片类药物滥用危机表示担忧 [1] - FDA 计划审查 OxyContin 等药物的标签，确保其准确性并与科学依据相符 [2] - FDA 致力于移除咨询委员会中所有可能的行业成员，以维护科学流程的公正性 [3] - FDA 将加强对已批准药物的上市后监测，利用大数据识别潜在的安全信号 [3][4] - FDA 将取消阻止安全流行病学研究的权限，确保安全团队能够自由工作，避免利益冲突 [5] Drug Approval & Transparency - FDA 正在进行全国范围的意见征集，听取 CEO 们对改进 FDA 的想法 [13] - FDA 致力于提高透明度，公开决策信函，使药品开发商能够了解药品未被批准的原因 [14][17] - FDA 正在利用 AI 技术来组织和分析大量的申请文件，以实现现代化 [18] - FDA 推出了一项试点计划，对于符合美国国家优先事项的药物，提供优先审查凭证，将决策时间缩短至 1-2 个月 [20] - FDA 员工数量自 2007 年以来翻了一番，存在大量冗余，需要进行整合 [21] Investment & Deregulation - FDA 采取放松监管的态度，旨在加快审批流程，同时不降低安全标准 [23] - FDA 将与行业保持沟通，确定哪些产品符合国家优先事项，例如满足未满足的公共卫生需求、实现国内生产以及提高药品的可负担性 [24] - FDA 计划对承诺在 OECD 国家和美国之间实现药品价格均等化的公司发放国家优先审查凭证，以激励市场中的良好行为 [25]

Today, multiple Democratic lawmakers, including some from Texas, are formally demanding answers from the administration about the impact of budget cuts and DHS policies on the government's ability to respond to the devastating floods. Texas Democratic Congressman Greg Quesar is one of them, chair of the Congressional Progressive Caucus, and he joins me now. Congressman, it's good to have you on the program again.What are the specific concerns both that you've heard raised but also the questions you want ans ...

Government Transparency & Whistleblower Protection - The report highlights concerns about the Trump administration's efforts to discredit whistleblowers and suppress information sharing with the press and public [1] - The analysis points out the importance of public servants speaking out to reveal information about the administration's actions [3] - The report mentions the Trump administration's use of polygraph tests to identify leaks and screen employees for loyalty at the FBI [7][8] - The analysis notes the firing of 18 inspectors general across the government, who are critical to protecting whistleblowers [8][9] - The report raises concerns about Trump's nomination of Paul Andracia to lead the Office of Special Counsel, an office that protects whistleblowers [10] Personnel & Qualifications - The report emphasizes Paul Andracia's limited government experience (barely a year) and questions his qualifications to run the 110-person Office of Special Counsel [11][12] - The report highlights Andracia's past association with controversial figures like Andrew Tate and his activity on social media, raising concerns about his judgment and objectivity [12][13][14] Political Implications - The report suggests that the appointment of Andracia is a deliberate attempt to undermine protections for federal employees who speak out against the administration [15] - The report mentions that Andracia's nomination requires Senate confirmation, leaving a sliver of hope for closer scrutiny [16]

Are we born as good communicators or do simple words still have an impact. On Mother's Day, I was telling my wife, Grace, a university instructor, how it was obvious that our four-year-old son, Rai, feels comfortable speaking in front of an audience at his school ceremony. I thought that given what we do in life, he kind of enjoys using a microphone in public.However, she reminded me how both of us were completely different not so long ago. And this got me thinking about my sophomore year when a group of st ...

Drug developers and inventors of new drugs are trying to figure out how do they get through this long, gnarly regulatory process. Well, we can be more transparent. We can provide better communications. We can provide guidance. We can answer questions on demand.And we are announcing that we're going to make our decision letters public so that drug developers can see why drugs are not accepted at the FDA. Why weren't they public. Some of the drug companies don't want them public.We learned that most companies ...

Today we published a targeted transparency framework for frontier AI development.Our framework focuses on major frontier model developers while exempting startups and smaller developers to avoid burdening the broader ecosystem. https://t.co/UrU8Vjtsm4 ...

get your bag - that's not a bad thing...but disclosure reallllllly needs to be normalized.audiences value transparency ...

RT Rob Paone (@crypto_bobby)This rant isn’t specifically about grass (although it applies a bit) but I think this type of attitude is horrific and the market is clearly punishing teams with this approachIf you don’t prioritize token holders with constant communication and transparency, your coin won’t do well.Things like the new Blockworks standard are a big step in the right directionBut launching a coin, not paying any real attention to it and then being like “we didn’t tell anyone to buy it” is such a co ...

To educate a man in mind and not in morals is to educate a menace to society. A ship is meant to be out at sea, but she's the safest in a harbor. Ethical conduct is the compass that guides us when we set sail into uncertain waters.Welcome everyone. My name is Captain Zar Irani. I've been out at sea for 14 years, done my time as they say, and have been involved in the maritime business for 20 34 years and counting.Today we're going to talk about the ethical compass of a marine business for that matter. These ...

Market Dynamics & Regulatory Landscape - Public markets have long been discussed for their benefits, but private markets also hold many companies, leading to the idea of public access to private markets [2] - The IPO market, once a primary way for companies to raise capital, has been overshadowed by robust private markets due to capital availability and impediments to being a public company [4][5] - The SEC aims to make IPOs more attractive by addressing red tape and impediments, with a focus on improving disclosure to make it more understandable and less driven by potential lawsuits [8][9] Investor Access & Protection - There's a debate on whether to make being a public company more attractive or to make private markets more accessible and transparent to the public [6] - The SEC will review rules regarding accredited investors, considering tweaking them due to investor demand for private products, while ensuring investors understand the risks involved [11] - Tokenization of assets, particularly private company shares like SpaceX, is seen as an innovation, but the SEC needs to provide clear regulations to foster innovation while ensuring investor protection [2][15][17] Innovation & Efficiency - The SEC aims to provide a firm regulatory foundation for innovation and new product development, moving away from regulation through enforcement [16][17] - Tokenization and other innovations can enhance trading and holding securities, potentially leading to quicker settlement times, building upon the move to T+1 settlement [18][19] - Digitization of securities and book entry, exemplified by the DTCC, was a significant advancement, and tokenization represents the next step towards greater market efficiency [20]