Core Findings - Researchers from the University of Konstanz and Queen Mary University of London have identified a key molecular signal, chemokine CXCL12, which induces erythroid progenitor cells to expel their nuclei, a critical step in red blood cell maturation [1][2] - This discovery provides a new pathway for large-scale production of artificial blood, addressing the long-standing challenges in artificial hematopoiesis research [1] Group 1: Research Significance - The process of blood generation in the human body is complex and not fully understood, with blood naturally produced in the bone marrow [1] - CXCL12, primarily found in the bone marrow, plays a crucial role in inducing erythroid progenitor cells to expel their nuclei, allowing for more efficient oxygen transport [1] Group 2: Implications for Artificial Blood Production - The ability to trigger the nuclear expulsion process in erythroid progenitor cells using CXCL12 could significantly enhance the efficiency of artificial blood production [2] - Future large-scale and personalized production of artificial blood could alleviate blood shortages, enable targeted synthesis of rare blood types, and facilitate autologous blood regeneration for precise treatments of diseases such as cancer and genetic disorders [2]