Core Viewpoint - The article discusses the effectiveness of different metabolic weight loss surgeries for patients with severe obesity, specifically comparing Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding, highlighting that Roux-en-Y is superior in weight loss and quality of life improvements [6][7][10]. Summary by Sections Study Overview - The By-Band-Sleeve study was conducted across 12 medical centers in the UK, focusing on the clinical efficacy and safety of three surgical methods for severe obesity [8]. - A total of 1,346 patients were recruited, with 405 undergoing Roux-en-Y, 342 sleeve gastrectomy, and 383 adjustable gastric banding after exclusions [8]. Weight Loss Outcomes - After three years, 68% of patients in the Roux-en-Y group lost over 50% of their body weight, compared to 41% in the sleeve gastrectomy group and 25% in the adjustable gastric banding group [10]. - The average weight loss was -26.8 kg for Roux-en-Y, -19.4 kg for sleeve gastrectomy, and 14.0 kg for adjustable gastric banding [11]. Quality of Life Improvements - The EQ-5D-5L scores indicated that Roux-en-Y and sleeve gastrectomy patients had significantly higher quality of life scores (0.72 and 0.68, respectively) compared to the adjustable gastric banding group (0.62) [10]. - The study established that Roux-en-Y and sleeve gastrectomy were superior to adjustable gastric banding in terms of both weight loss and quality of life [10]. Health Complications - Roux-en-Y gastric bypass showed the most significant improvement in obesity-related complications such as diabetes and dyslipidemia [10]. - The study reported a reduction in HbA1c levels and fasting blood glucose across all groups, with Roux-en-Y showing the best outcomes [11]. Safety Profile - A total of 1,651 adverse events were reported, with Roux-en-Y, sleeve gastrectomy, and adjustable gastric banding having annual adverse event rates of 6.0, 5.7, and 4.6, respectively [11]. - The study recommends prioritizing Roux-en-Y gastric bypass for severe obesity patients, with sleeve gastrectomy as an alternative if Roux-en-Y is not feasible [11].

以下文章来源于肥胖世界ObesityWorld ，作者欢迎订阅 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 Lancet Diabetes & Endocrinology发表By-Band-Sleeve研究结果，表明在减重效果、提高生活质量和减少合并症方面，Roux-en-Y胃旁路术、 袖状胃切除术优于可调节胃束带术。Roux-en-Y胃旁路术在减重效果方面又优于袖状胃切除术。 By-Band-Sleeve研究在英国12家医疗中心展开，针对重度肥胖患者，系统比较了Roux-en-Y胃旁路术、袖状胃切除术和可调节胃束带术的临床 疗效与安全性。所有受试者在手术前2至4周均接受了低热量饮食，同时根据个人健康状况，研究团队为部分患者配备了抗血栓药物和抗生素。 三种手术均采用腹腔镜微创方式进行。研究共招募了1346名患者进行随机分组，剔除未实际接受手术及术式交叉的患者后，最终405人接受了 Roux-en-Y胃旁路术，342人接受了袖状胃切除术，383人接受了可调节胃束带术 ...