同时，研究团队发现，蝗虫体内的两种关键酶4VPMT1和4VPMT2，专门负责4VA合成的最后一 步。"这两种关键酶是阻止蝗虫聚集的绝佳'靶子'。"论文共同通讯作者、北京大学教授雷晓光说，"根据 这两个关键酶的工作原理，我们设计出一种小分子抑制剂。这个抑制剂能精准关闭4VA的生产线，阻止 其释放。实验证明，这种方法能成功干扰蝗虫，让它们无法有效聚集。" 康乐表示，这项研究不仅揭示了蝗虫聚集的深层分子机制，更重要的是为害虫防治提供了新思路 ——通过干扰昆虫的信息交流来控制其行为，而非使用传统农药。这种方法有望推动农业害虫治理向绿 色、可持续方向发展，对保障粮食安全和生态安全具有重要意义。 蝗虫在啃噬玉米叶。康平 ( 云南分社 )/ 中新社 蝗灾与旱灾、洪灾并称为我国历史上的三大自然灾害，曾造成严重的农业和经济损失。记者7月7日 从中国科学院动物研究所获悉，该所中国科学院院士康乐团队与合作者成功解析了蝗虫群聚信息素 （4VA）在蝗虫体内的完整产生过程，并找到了制造4VA的关键酶。基于这些发现，研究团队设计出了 一种小分子抑制剂，能够精准调控4VA的合成和释放，从而有效干预蝗虫的群聚行为。相关研究成果日 前在线发表于 ...

Core Insights - The research focuses on the biosynthesis pathway of the locust aggregation pheromone 4-vinylphenol (4VA), which is crucial for pest control strategies in agriculture [1][3] - The study reveals that locusts utilize common amino acids from plants to synthesize their specific aggregation pheromone, showcasing an energy-efficient adaptation strategy [2] Group 1: Pheromone Biosynthesis - The complete biosynthesis pathway of 4VA has been elucidated, identifying key precursor compounds and enzymes 4VPMT1 and 4VPMT2 [1] - The transformation of 4VP to 4VA is mediated by the precise regulation of 4VPMTs expression, allowing for the release and termination of the pheromone [2] Group 2: Chemical Regulation - The study developed specific small molecule inhibitors targeting 4VPMTs, enabling precise chemical control over the biosynthesis and release of 4VA [3] - The inhibitor 4-nitrophenol (4NP) competes with 4VP for binding to 4VPMTs, demonstrating a high affinity that allows for selective inhibition of 4VA synthesis [3] Group 3: Implications for Pest Control - This research provides a novel strategy for pest management by intervening in insect pheromone pathways rather than relying on traditional chemical pesticides [3] - The findings suggest a potential shift in pest control methods from reliance on chemical insecticides to more precise and environmentally friendly behavioral regulation [3]

Core Viewpoint - Chinese researchers have successfully decoded the aggregation pheromone of locusts, enabling ecological prevention of locust plagues through precise chemical regulation of the pheromone's biosynthesis and release [1][6]. Group 1: Research Achievements - The research team from the Chinese Academy of Sciences and Peking University has identified the complete biosynthetic pathway of the locust aggregation pheromone 4-vinylphenol (4VA) [3][4]. - Key precursor compounds and essential biosynthetic enzymes (4VPMT1 and 4VPMT2) for 4VA have been successfully identified [4][5]. Group 2: Implications for Pest Control - The study provides a new approach to pest control by developing specific small molecule inhibitors that can regulate locust aggregation pheromone, potentially allowing for targeted interventions [5][7]. - This method aims to reduce the reliance on traditional chemical pesticides, which often harm beneficial insects and contaminate the environment [7][8]. Group 3: Future Directions - The research opens up new pathways for sustainable pest management by utilizing insect pheromones to control locust behavior, thereby minimizing ecological damage [7][8]. - The findings could lead to innovative strategies for biological pest control, such as using antagonists to disrupt locust aggregation and enhance natural predation by birds [7][8].

香水界又来新角儿了：ABO信息素香水。 一般香水靠疼痛青春式名字和文案唤起你无限遐思，靠花里胡哨的包装设计诱你见色起意；而信息素香水，大道至简、大音希声、大象无形，没有精雕细 琢的文案，没有通感叠加隐喻的名字，卖的恰是于你最熟悉却又最神秘的味道—— 你自己的味道。 更具体地说，这种香水能让你"信息素"的味道扩散出去，主打一个千人千味、独一无二、AO分明。 有人已躬身入局，有人还疑窦丛生，什么ABO，什么信息素，叽里呱啦说啥呢？你身上到底有谁的香水味，将你酷烈或温柔来分类？ 原来我闻着竟是这样三分冷峻、 三分清别、四分风流倜傥 香水的价值常常在于文案、在于设计、在于品牌，偶尔也可以在于味道；而信息素香水的价值，类同性格测试、近似玄学看相，它们都面向一个问题：我 到底是个啥人？ 点开信息素香水的评价区，你会发现买家们已经完全沉浸在对自我和亲朋的嗅觉剖析里了。 有人发现自己和对象的信息素十分般配："我刚喷上是茉莉香，静置一会儿又像雨后青草的味道，应该是小O吧；男朋友的信息素是木质香加皮革味，还 有一点烟草的气息，包是猛A的。" 有人庆幸自己是香的："好消息，没有臭臭怪味，像掺了奶味的肥皂。" 当然也就有人惊觉自己是 ...

Core Viewpoint - The research led by Chinese Academy of Sciences academician Kang Le has made significant progress in locust control by identifying the biosynthetic pathway of the key pheromone 4-vinylphenol (4VA) and discovering several small molecule inhibitors that can suppress its production, providing an effective and sustainable strategy for locust disaster control [1][3][4] Group 1: Research Findings - The study published in the prestigious journal "Nature" reveals that the frequent occurrence of locust swarms poses a global threat to the environment, agriculture, and economy [3] - Traditional methods of locust control rely on chemical pesticides, which have adverse effects on the environment, food safety, and human health [3] - The research team traced the molecular origin of 4VA, finding that its biosynthesis begins with the plant-derived amino acid phenylalanine and involves several intermediates before converting to 4VA [3] Group 2: Inhibitors and Mechanisms - The research identified two methyltransferases that respond to changes in locust population density, controlling the final step of 4VA synthesis [3] - A compound named 4-nitrophenol was found to be a potent candidate for inhibiting the function of these enzymes, leading to the proposal of several similar compounds that can suppress 4VA synthesis [3][4]

科技赋文明，共鉴谋发展。四月的曲阜，春风送来文明碰撞的交响。4月25日，第四届全球媒体创 新论坛在曲阜尼山举行。海内外传媒学界专家、业界代表齐聚孔子故里，交流对话、凝聚共识，共绘新 一轮科技革命和产业变革中文明发展新蓝图。 "我们生活的时代，新技术与全球紧张局势深刻重塑人们获取可靠、优质信息的方式。"联合国教科 文组织副总干事曲星说，当下，数字平台日益成为新闻资讯的主要载体，煽动性内容、仇恨言论和虚假 信息日益泛滥，教科文组织致力于推动全球媒体与信息素养建设，让年轻一代能够更安全地使用数字平 台。"我们秉持一个坚定信念，让所有人平等获取优质信息，是实现持久和平的重要基石。"（记者 杨 帆 实习生 邢奕萱） 全球媒体创新论坛是由中国中央广播电视总台创办的具有广泛影响力的国际媒体交流平台，从2022 年开始已连续举办四届。本届论坛以"交流互鉴 科技赋能——变革发展中的文明力量"为主题，下设6个 分论坛，涵盖青年视角、科技与人文、全球舆论生态、绿色转型、机器人产业和AI应用等议题，邀请 嘉宾围绕人类发展、科技进步、媒体协同以及AI创新应用等主题展开讨论，应世界之变、时代之变， 就新时代媒体创新发展达成共识。 文化之 ...