化学重编程技术

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Cell:中国科学家突破糖尿病治疗!或实现首次治愈
GLP1减重宝典· 2025-07-15 09:32
Core Viewpoint - A groundbreaking study from Chinese scientists has demonstrated the potential for curing type 1 diabetes through stem cell technology, marking a significant advancement in the treatment of this chronic condition [4][5][7]. Group 1: Breakthrough in Type 1 Diabetes Treatment - The study published in *Cell* details the world's first successful case of a patient with type 1 diabetes being able to stop insulin use after receiving a transplant of chemically induced pluripotent stem cell-derived islets (CiPSC) [5][7]. - The patient, a 25-year-old male with a history of liver complications and previous unsuccessful pancreas transplant, achieved stable blood sugar levels within 75 days post-transplant, with HbA1c dropping to 5% and time in range (TIR) exceeding 98% [6][7]. - This case not only validates the safety and efficacy of CiPSC transplantation but also offers a new clinical pathway for potentially curing type 1 diabetes, which has traditionally been viewed as a lifelong condition requiring insulin [7][8]. Group 2: Innovative Techniques and Future Implications - The treatment utilizes chemical reprogramming to convert the patient's own pluripotent stem cells into functional insulin-producing cells, overcoming previous limitations related to cell sourcing [8]. - The innovative choice of the abdominal anterior rectus sheath as the transplant site has shown promising results, indicating a significant advancement in the methodology of diabetes treatment [8]. - The medical community views this achievement as a pivotal moment in regenerative medicine for metabolic diseases, with the potential to reshape diabetes treatment paradigms if further large-scale clinical trials confirm these results [8].