肿瘤相关中性粒细胞 （TAN） 在各类癌症中普遍存在，但其表型多样性和功能状态仍不明确。 在这项最新研究中，研究团队开发了一种 细胞类型概率分类器 ，它能够从单细胞 RNA 测序 （scRNA- seq） 数据集中 有效识别转录本表达量低的中性粒细胞 ， 解决了以往检测难题，为泛癌种 肿瘤相关中性 撰文丨王聪 编辑丨王多鱼 排版丨水成文 中性粒细胞 （ Neutrophils ） 是人体抵御损伤和感染的第一道防线，但它们在癌症中也发挥着基础性作 用。在许多人类癌症中都报告了中性粒细胞数量增多的情况，且这往往与不良预后相关。在小鼠模型中， 肿瘤相关中性粒细胞 （TAN） 能够促进肿瘤生长并调控治疗反应。然而，中性粒细胞在功能上是异质性 的，似乎只有部分中性粒细胞会积极促进癌症发展。 2026 年 2 月 6 日，日内瓦大学的研究人员在 Cancer Cell 期刊发表了题为： CCL3 is produced by aged neutrophils across cancers and promotes tumor growth 的研究论文。该研究表明， CCL3 由多 种癌症中的衰老 中性粒细胞 产生，并 促 ...

Core Viewpoint - The research developed human airway submucosal gland (SMG) organoids to study respiratory inflammation and infection, marking a significant advancement in organoid research and its applications in drug development and regenerative medicine [2][3]. Group 1: Research Background - The study was led by Hans Clevers' team, with Lin Lin as the first author, and published in Cell Stem Cell on June 12, 2025 [2]. - The development of organoids began in 2009 with the cultivation of intestinal organoids from mouse intestinal stem cells, which opened the era of organoid research [2]. Group 2: Importance of SMG - SMG plays a crucial role in mucus secretion and host defense, containing various cell types that contribute to airway moisture and pathogen resistance [7]. - Recent studies indicate that SMG aids in the repair and regeneration of airway epithelium after injury, suggesting its potential as a reservoir of multipotent progenitor cells [8]. Group 3: Research Findings - The research established human organoids from primary bronchial tissues to explore the unique physiological characteristics of SMG and surface airway epithelium (SAE) [9]. - Single-cell RNA sequencing confirmed that the organoid models accurately replicate the inherent cellular heterogeneity of each tissue type, with SMG organoids rich in MUC5B-producing cells [9]. Group 4: Key Highlights - The study successfully cultivated SMG organoids from human bronchial tissue [10]. - ANPEP/CD13 was identified as a specific marker for glandular secretory cells [10]. - The research demonstrated that cytokines related to chronic obstructive pulmonary disease (COPD) trigger different inflammatory responses in the organoids [10]. Group 5: Conclusion - The SMG organoid model serves as a new tool for investigating the complex roles of SMG in human airways, providing a more physiologically relevant system for studying responses to infection and inflammation [12].