Core Insights - The International Agency for Research on Cancer (IARC) and the World Health Organization (WHO) have quantified the global burden of preventable cancers for the first time, revealing that nearly 40% of new cancer cases in 2022 are linked to modifiable risk factors [1][2] Group 1: Cancer Burden and Risk Factors - In 2022, there were approximately 18.7 million new cancer cases globally, with around 7.1 million cases attributable to 30 modifiable risk factors [2] - Major contributing factors include smoking (15.1%), infections (10.2%), and alcohol consumption (3.2%), with lung, stomach, and cervical cancers accounting for nearly half of these preventable cases [2] - For women globally, human papillomavirus and Helicobacter pylori infections are the largest cancer risk factors, associated with 11.5% of cases, while for men, smoking is the largest risk factor, linked to 23.1% of cases [2] Group 2: Regional Differences and Opportunities - There are significant regional differences in cancer cases related to modifiable risk factors, with 57.2% of cancer cases in East Asian men linked to these factors, compared to 28.1% in men from Latin America and the Caribbean [2] - The research highlights potential opportunities for cancer prevention, including smoking cessation, infection prevention, and tailored prevention strategies for different countries [3] - The study emphasizes the need for improved monitoring systems and data availability, particularly in low- and middle-income countries, to enhance future estimates and inform policy-making [3]