Group 1 - Stanford University and Elsevier published the 2025 "Top 2% Global Scientists" list, recognizing the top 2% of scholars from nearly 7 million researchers worldwide [1] - Professor He Xiaoshun, Director of the Organ Transplant Center at Sun Yat-sen University First Affiliated Hospital, was honored on this list and is also the founder and chief scientist of Singularity Medical Technology [2] Group 2 - Professor He Xiaoshun is a pioneer in organ medicine, having performed the world's first non-ischemic liver transplant in 2017 and introduced the concept of "organ medicine" in 2019 [3] - The "Domino-Extracorporeal Liver Support Therapy" developed by his team provides new hope for critically ill patients who cannot undergo transplantation [3] - The "extracorporeal liver" technology allows for the maintenance of non-transplantable but functional livers, providing essential liver function support to patients in need [3] Group 3 - Singularity Medical, established in May 2020, focuses on organ medicine research and development, with a pipeline covering organ transplantation, donation, isolation treatment, and new drug development [4] - The company has achieved significant milestones, including the world's first vascular intervention for liver cancer isolation treatment and the revival of a pig brain after 50 minutes of death [4] - The company has a strong R&D team, with 51% of its workforce dedicated to research, and has filed 61 patents, with 44 granted [4] Group 4 - Singularity Medical's first innovative medical device, the "Liver Perfusion System," has entered the special review process by the National Medical Products Administration, with full case enrollment expected by October 2025 and registration anticipated by 2027 [4] - Another core product, the "Donor Perfusion System," received approval for special review in June 2025, with efforts underway to expedite clinical trials [4]

Core Insights - Professor He Xiaoshun from Sun Yat-sen University First Affiliated Hospital has been selected as one of the "Top 2% Global Scientists" for 2025, highlighting his significant contributions to organ medicine [2][7][64] Group 1: Breakthroughs in Organ Medicine - The "Extracorporeal Liver" technology allows for the maintenance of non-transplantable but functionally viable livers outside the body, providing critical support to patients with liver failure [13][15] - The "Domino" technique utilizes the liver of a previous transplant recipient to support the next patient, creating a chain of benefits for multiple patients [16][17] - A case study involving a patient with acute liver failure demonstrated the effectiveness of the "Domino-Extracorporeal Liver Support Therapy," which ultimately led to a successful liver transplant [19][33] Group 2: Innovations in Brain Preservation - Professor He Xiaoshun's team successfully revived a pig brain that had been deprived of blood supply for 50 minutes, showcasing the potential for this technology in treating critical conditions like cardiac arrest [40][50] - This experiment indicates the possibility of applying similar techniques in neuroscience research, potentially transforming future medical practices [51] Group 3: Human Disease Organ Models - The team developed a "Human Disease Organ Maintenance System" that allows for the long-term preservation of excised diseased organs, creating realistic models for studying human diseases [59][60] - This innovation facilitates in-depth exploration of disease mechanisms, efficient drug screening, and accelerated discovery of biomarkers, significantly shortening research timelines [62][63]