Summary of Karyopharm Therapeutics Special Meeting Company Overview - **Company**: Karyopharm Therapeutics, Inc. (NasdaqGS: KPTI) - **Meeting Date**: February 18, 2026 - **Participants**: Richard Paulson (President, CEO, and Director), Michael Mano (Chief Legal Officer), Lori Macomber (Chief Financial Officer), Brendan Strong (Senior Vice President of Investor Relations) [1][2][3] Key Proposals Discussed 1. **Proposal One**: - Adoption and approval of an amendment to the restated certificate of incorporation to increase the number of authorized shares of capital stock from **58,333,333** to **111,000,000**. - Increase the number of authorized shares of common stock from **53,333,333** to **106,000,000** [7][9]. 2. **Proposal Two**: - Approval to adjourn the special meeting to a later date if necessary for further solicitation of proxies in case of insufficient votes for Proposal One [7][10]. Voting Results - A quorum was established with **18,310,283** shares of common stock entitled to vote present [5][6]. - Both proposals were approved based on preliminary voting results: - Proposal One to increase authorized shares was approved. - Proposal Two to allow for adjournment was also approved [9][10]. Important Notes - The meeting was conducted in a virtual format, allowing stockholders to participate similarly to an in-person meeting [2]. - Forward-looking statements were made, with a disclaimer regarding reliance on these statements due to potential differences in actual results [4]. - The final vote results will be documented in a Form 8-K to be filed within four business days after the meeting [10]. Additional Information - Stockholders were encouraged to submit questions related solely to the proposals during the meeting, but no questions were raised [7][8]. - The meeting concluded with gratitude expressed to shareholders for their participation and support [10].

Financial Data and Key Metrics Changes - The company reported that all nominees for election to the board have been duly elected, and the appointment of Simon & Edward as the independent registered public accounting firm for the fiscal year ending December 31, 2025, has been ratified [19] - An amendment to effect a reverse stock split of the company's common stock and an increase in the number of authorized shares from 100 million to 500 million have been approved [19] Business Line Data and Key Metrics Changes - No specific data on business lines or key metrics changes were provided in the meeting [20] Market Data and Key Metrics Changes - No specific market data or key metrics changes were discussed during the meeting [20] Company Strategy and Development Direction and Industry Competition - The company is focusing on increasing its authorized shares significantly, which may indicate plans for future growth or capital raising [19] Management's Comments on Operating Environment and Future Outlook - Management did not provide specific comments on the operating environment or future outlook during the meeting [20] Other Important Information - The meeting was conducted virtually, allowing shareholders worldwide to participate conveniently [2] - Stockholders were informed that the final vote totals would be included in a current report on Form 8-K filed with the Securities and Exchange Commission within four business days [6][19] Q&A Session All Questions and Answers - There were no questions from stockholders during the Q&A session [20]

Financial Data and Key Metrics Changes - The company reported a total of 36,085,978 shares of common stock outstanding as of the record date [4] - The company has 50,000 shares of Series C preferred stock outstanding entitled to vote at the meeting [4] Business Line Data and Key Metrics Changes - No specific business line data or key metrics were provided in the meeting records Market Data and Key Metrics Changes - No specific market data or key metrics were provided in the meeting records Company Strategy and Development Direction and Industry Competition - The company proposed a reverse stock split of its common stock at a ratio of not less than one for 20 and not more than one for 50, with the exact timing and ratio to be determined by the Board of Directors [8][14] - The company also proposed to increase the number of authorized shares of common stock from 100 million to 500 million [9][15] Management's Comments on Operating Environment and Future Outlook - Management did not provide specific comments on the operating environment or future outlook during the meeting Other Important Information - The meeting was conducted virtually, allowing shareholders worldwide to participate conveniently [2] - The company emphasized that any forward-looking statements made during the meeting are subject to significant risks and uncertainties [10][11] Q&A Session All Questions and Answers Question: Were there any questions from stockholders? - There were no questions submitted by stockholders during the Q&A session [18]

Financial Data and Key Metrics Changes - The company proposed an amendment to increase the number of authorized shares of common stock from 7,500,000 to 400,000,000, following a reverse split to meet New York Stock Exchange requirements [4][5]. Business Line Data and Key Metrics Changes - No specific data on business lines or key metrics was provided in the meeting [8]. Market Data and Key Metrics Changes - No specific market data or key metrics were discussed during the meeting [8]. Company Strategy and Development Direction and Industry Competition - The increase in authorized shares is aimed at ensuring the company can function properly and support its growth strategy [4][5]. Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the proposal to amend the Articles of Incorporation, indicating a positive outlook for the company's operational capabilities [4][5]. Other Important Information - The proposal was approved by the required vote of stockholders, with final voting results to be reported in a current report Form 8-K to be filed with the SEC [7]. Q&A Session Summary - There were no questions presented during the Q&A session, and the meeting concluded without further inquiries [6][7].

Financial Data and Key Metrics Changes - The company proposed to increase the number of authorized shares of common stock from 7,500,000 to 400,000,000, following a reverse split to meet New York Stock Exchange requirements [4][5]. Business Line Data and Key Metrics Changes - No specific data or metrics regarding individual business lines were provided in the meeting [6]. Market Data and Key Metrics Changes - No specific market data or metrics were discussed during the meeting [6]. Company Strategy and Development Direction and Industry Competition - The proposal to amend the Articles of Incorporation is aimed at ensuring the company can function properly in the market [4][5]. Management's Comments on Operating Environment and Future Outlook - Management did not provide specific comments on the operating environment or future outlook during the meeting [6]. Other Important Information - The proposal to increase the authorized shares was approved by the required vote of stockholders, with final voting results to be reported in a current report Form 8-K filed with the SEC [7]. Q&A Session All Questions and Answers Question: Were there any questions from stockholders? - No questions were presented during the Q&A session [6][7].