Core Viewpoint - The recent increase in flu cases across China has raised concerns regarding the side effects of antiviral medications, particularly Oseltamivir, in children, with reports of adverse reactions including psychological symptoms and drug resistance [1][5][10]. Group 1: Flu Cases and Medication Usage - Recent data from the Chinese Center for Disease Control indicates that nearly 45% of respiratory samples from patients with flu-like symptoms tested positive for the flu virus [1]. - Common antiviral medications include Oseltamivir and Baloxavir, with specific age and weight restrictions for their use [1]. - Parents have reported adverse reactions in children after taking Oseltamivir, including hallucinations and gastrointestinal issues [2][5]. Group 2: Adverse Reactions and Concerns - Reports from parents highlight concerns about Oseltamivir causing psychological symptoms in children, such as confusion and agitation [5][6]. - Clinical trials have identified vomiting as the most common side effect in children aged one and older, with rare cases of behavioral abnormalities and delirium reported post-approval [6][7]. - Experts suggest that while psychological symptoms can occur, they are extremely rare, and the most common side effects remain gastrointestinal [6][7]. Group 3: Drug Resistance Issues - There are growing concerns about the potential for Oseltamivir resistance, with reports of reduced effectiveness in some patients [7][10]. - Analysis of flu virus strains has shown that while some strains exhibit resistance to Oseltamivir, the currently circulating H3N2 strain remains sensitive to both Oseltamivir and Baloxavir [9][10]. - Experts emphasize the need for rigorous testing to determine the actual resistance levels and the impact of viral mutations on drug efficacy [10][11]. Group 4: Recommendations for Treatment - Medical professionals recommend that parents should not overly worry about rare side effects and should follow medical advice regarding the use of Oseltamivir [11]. - It is advised that antiviral medications should only be used when there is clear evidence of flu infection, to avoid unnecessary side effects and potential resistance [11].