Core Viewpoint - The research conducted by teams from Shanghai Jiao Tong University and Naval Medical University focuses on developing an engineered epoxidase that significantly simplifies the synthesis of meroterpenoids by enhancing the asymmetric epoxidation of farnesol [3][4]. Group 1: Research Development - The study published in the journal Science introduces a novel strategy that integrates enzyme catalysis with classical synthetic chemistry to construct meroterpenoids [3]. - The research team utilized directed evolution technology to engineer an epoxidase that exhibits unique selectivity for the internal olefin sites of farnesol [4]. Group 2: Synthesis Efficiency - The engineered epoxidase catalyzes the epoxidation reaction with high regioselectivity and enantioselectivity, leading to the production of epoxide intermediates [4]. - This method has successfully simplified the synthetic pathways for various meroterpenoids, reducing the total synthesis steps by more than 50% in most cases [4].