Core Viewpoint - Cell Press launched a new open-access journal, Cell Press Blue, in December 2025, focusing on significant pioneering research in life sciences, physical sciences, medicine, sustainable development, and applied sciences [2]. Group 1: Journal Overview - Cell Press Blue welcomes interdisciplinary research that connects biology, medicine, chemistry, physics, materials science, energy, environmental science, and sustainable development [2]. - The journal will also publish authoritative reviews and opinion articles to showcase emerging opportunities and reflect on the role of science in addressing major contemporary challenges [2]. Group 2: Research Findings - The first paper published in Cell Press Blue, authored by Ellen Foxman's team from Yale University, investigates how rhinovirus triggers distinct host responses through different engagement of epithelial innate immune signaling [3]. - Rhinovirus is a common viral infection responsible for approximately half of all colds and is a major trigger for asthma and COPD exacerbations [5]. - The study utilized human nasal epithelial organoid models and single-cell sequencing to demonstrate that different activation of innate immune signaling pathways alters the inflammatory response in rhinovirus target cells [5]. Group 3: Molecular Mechanisms - The research reveals molecular mechanisms that lead to varying host responses to rhinovirus infection and identifies potential therapeutic targets [6]. - Blocking interferon responses results in increased IL-1β release and excessive mucus production, indicating a critical role of the epithelial interferon response in limiting rhinovirus infection [7][9]. - The study establishes a comprehensive resource for understanding the epithelial cell response spectrum to rhinovirus infection and suggests that targeting the NLRP1-IL-1 signaling axis may serve as a potential therapeutic strategy to alleviate airway obstruction caused by rhinovirus [9].