Core Points - The U.S. federal government has laid off approximately 4,200 employees across at least eight departments, with the Department of the Treasury being the most affected, losing 1,450 employees [1] - The Community Development Financial Institutions Fund (CDFI), which supports low-income communities, has also seen all 83 of its employees laid off, despite bipartisan support in Congress [2] - The Department of Health and Human Services has over 1,300 employees affected by layoffs, while the Department of Education has 466 employees facing job losses [4][5] Departmental Layoffs - The Department of the Treasury has the highest number of layoffs, totaling 1,450 employees [1] - The Department of Health and Human Services is the second most affected, with over 1,300 employees receiving layoff notices [4] - The Department of Education has laid off 466 employees, impacting special education services and school funding [5] Political Reactions - Some Republican senators have publicly opposed the layoffs initiated by the Trump administration, expressing concerns about the impact on federal employees and public service missions [6] - Bipartisan support for the CDFI was highlighted, with 23 senators emphasizing its critical role in community service and the economic return on investment [2]