Core Points - The World Health Organization (WHO) African Regional Office and the International Vaccine Institute (IVI) signed a memorandum of understanding to enhance strategic cooperation in vaccine equity, local production, and health innovation in Africa [1] - The signing took place during the 75th session of the WHO African Regional Committee in Lusaka, Zambia, from August 25 to 27, 2025, marking a new phase in efforts to improve access to life-saving vaccines and medicines for the African population [1] - The agreement aims to strengthen regional capabilities in vaccine research, development, and manufacturing, which are critical for health sovereignty and pandemic preparedness [1] Summary by Sections - **Vaccine Production and Equity** - The memorandum reflects a commitment to invest in local vaccine production in Africa to address emerging health threats and reduce reliance on external supply chains [1] - This initiative is seen as a step towards achieving equity, resilience, and self-sufficiency in health [1] - **Significance of the Agreement** - The timing of the agreement is crucial due to new constraints on global health financing, highlighting the importance of regional partnerships like that of WHO and IVI to maintain progress and prioritize health issues in Africa [1]