母婴微生物传播

Search documents
Cell子刊:母亲口腔病菌会传播到婴儿肠道,长期影响肠道免疫,增加肠炎易感性
生物世界· 2025-07-17 03:26
Core Viewpoint - The study highlights the impact of maternal oral microbiome dysbiosis on the gut microbiome of offspring, leading to long-term health implications, particularly an increased susceptibility to enteritis in adulthood [3][5][8]. Group 1: Research Findings - Maternal oral pathobionts can be transmitted to the infant gut, altering gut immunity and predisposing offspring to enteritis [3][10]. - The research demonstrated that periodontal disease in mother mice, induced by dental floss ligation, led to the expansion of oral pathogenic bacteria, which were then transmitted to their offspring [6][10]. - Despite the eventual clearance of these pathogenic symbionts from the offspring's microbiome, the imprint of susceptibility to enteritis persists into adulthood [7][10]. Group 2: Implications - Dysbiosis of the maternal oral microbiome not only affects the early gut microbiome of infants but may also have lasting effects on the long-term health of the offspring [8][10].