溶酶体影响寿命

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线虫研究揭示长寿跨代传递机制
Huan Qiu Wang Zi Xun· 2025-09-29 02:01
Core Viewpoint - Recent research from the Howard Hughes Medical Institute reveals that changes in lysosomes in Caenorhabditis elegans (a type of nematode) that extend parental lifespan can be transmitted to offspring, resulting in increased longevity without altering DNA sequences [1] Group 1: Research Findings - Lysosomes, previously considered as cellular "recycling centers," are now shown to influence lifespan through epigenetic mechanisms, specifically chemical markers that regulate gene expression [1] - The study indicates that lifespan-extending changes in somatic cells can be passed to germ cells via histone modifications, allowing offspring to inherit longevity advantages [1] - Overexpression of a specific enzyme in the lysosomes of nematodes led to a 60% increase in lifespan, and even unmodified offspring exhibited extended lifespans, demonstrating the transgenerational effect [1] Group 2: Mechanism of Transmission - The transgenerational transmission of lifespan extension relies on histones, with lysosomal changes activating cellular processes that increase specific histone variants [1] - These histones are transported from somatic cells to germ cells via nutrient transport proteins, allowing the lysosomal information to be modified and passed on to subsequent generations [1]