Core Viewpoint - The article emphasizes the urgent need for personalized interventions in the prevention and management of prediabetes, highlighting that not all individuals respond equally to lifestyle changes aimed at reversing prediabetes [5][7][13]. Summary by Sections Diabetes Prevalence and Risks - China faces a severe diabetes prevention and treatment situation, with 140 million diagnosed patients and approximately 500 million individuals in a prediabetic state. Without effective interventions, the risk of developing diabetes in these prediabetic individuals could rise to 95.9% over 30 years [5]. Importance of Personalized Interventions - A recent comprehensive review published in a leading journal indicates that the effectiveness of interventions is closely related to individual characteristics. The study underscores the importance of personalized interventions, as lifestyle changes can significantly vary in effectiveness based on baseline metabolic traits, genetic background, and the extent of lifestyle modifications [7][9]. Meta-Analysis Findings - A meta-analysis involving 31 randomized controlled trials and 236,834 participants found that lifestyle interventions can reduce the risk of progression from prediabetes to type 2 diabetes by 41% (RR 0.59, 95% CI 0.52 – 0.68) and increase the probability of normalizing blood sugar levels by 44% (RR 1.44, 95% CI 1.15 – 1.81) [9][10]. Differential Impact Based on Prediabetes Type - The study revealed that individuals with impaired glucose tolerance (IGT) benefit the most from lifestyle interventions, with a 23% reduction in diabetes risk (RR 0.77, 95% CI 0.64 – 0.93). In contrast, those with isolated impaired fasting glucose (IFG) and non-diabetic hyperglycemia (NDH) showed limited benefits [10][11]. Long-term Effects of Lifestyle Interventions - Long-term follow-up studies indicate that lifestyle interventions can delay the onset of type 2 diabetes by up to 5 years. However, there were no significant differences in cardiovascular disease incidence (HR 0.95, 95% CI 0.73 - 1.24) and all-cause mortality (HR 0.84, 95% CI 0.63 - 1.11) between intervention and control groups [11][12]. Key Insights for Future Interventions - The research highlights the necessity of moving away from a "one-size-fits-all" approach to diabetes prevention, advocating for a precision intervention system based on metabolic profiling. It emphasizes the need to consider individual metabolic characteristics and explore optimal intervention strategies, including exercise intensity and dietary composition [13]. Overall Health Benefits of Lifestyle Changes - While the study confirms individual differences in response to lifestyle interventions, it also stresses that maintaining a healthy lifestyle offers benefits beyond blood sugar control, contributing to overall health, work efficiency, and quality of life [13].